Evaluation of plaque destabilization by pregnancy-associated plasma protein a (PAPPA) and coagulant activity did not predict reccurent Troponin-T positive cardiac events following an acute myocardial infarction
Abstract number: PP-WE-831
Brügger-Andersen1 T., Aarset⊘y2 H., Grundt2 H., Nilsen2 D.W.T.
11Department of Cardiology, Stavanger University Hospital 22Department of Medicine, Stavanger University Hospital, Institute of Medicine, UiB, Stavanger, Norway
How-to-cite Brügger-Andersen T, Aarset⊘y H, Grundt H, Nilsen DWT. Evaluation of plaque destabilization by pregnancy-associated plasma protein a (PAPPA) and coagulant activity did not predict reccurent Troponin-T positive cardiac events following an acute myocardial infarction. Journal of Thrombosis and Haemostasis 2009; Volume 7, Supplement 2: Abstract PP-WE-831
Background: We have previously clearly demonstrated that PAPPA is released during percutaneous coronary intervention, and this metalloproteinase may play an important part in coronary artery disease progression and plaque destabilization, whereas tissue factor (TF) triggers coagulation as reflected by fibrin monomer (FM).
Methods: We compared the recurrency of troponin-T (TnT) positive coronary events in the upper quartile of PAPPA measured in serum to the event rate below the 75% percentile during a median follow-up period of 4.5 years in patients with an acute myocardial infarction (MI). Tissue factor (TF) and fibrin monomer (FM) in citrated plasma were also evaluated in relation to prognosis. Blood samples were drawn 4–6 days post-MI in 300 patients. Analyses of PAPPA, TF and FM were performed by ELISA-methodology.
Results: During the follow-up period 82 patients suffered an adverse TnT positive event. In the upper quartile of PAPPA 35.1% had a secondary TnT positive coronary event, as compared to 24.8% in the three lower quartiles of PAPPA, P = 0.111. Furthermore, there were no significant differences in recurrent events when comparing the upper to the lower quartiles of TF and FM. No significant correlation was observed between the measured biomarkers.
Table: Number and proportion of patients with first recurrent troponin-T positive event
|PAPPA||First recurrent troponin-T positive event|
|Q4 (> 0.72 μlU/mL)∗||27 (35.1)|
|Q3 (> 0.49–0.72 μlU/mL)||15 (20.6)|
|Q2 (0.31–0.49 μlU/mL)||19 (25.7)|
|Q1 (< 0.31 μlU/mL)||21 (28.0)|
|∗Chi Square, P = 0.111, Q4 vs. Q1–Q3. Values presented as number (%).|
Conclusion: Our results failed to demonstrate a prognostic impact of PAPPA, and secondary coagulant activity as judged by TF and FM in relation to future TnT-positive cardiac events in survivors of an acute MI.
Disclosure of interest: none declared.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
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