Elevated thrombin generation in relatives of patients with unprovoked venous thromboembolism and no detectable thrombophilia
Abstract number: PP-MO-310
Couturaud1 F., Duchemin2 J., Quere1 G., Kearon3 C., Ginsberg4 J., Leroyer1 C., Mottier1 D., Abgrall2 J.
11Department of Internal Medicine and Chest Disease 22Haematology Unit, EA 3878, GETBO, IFR 148, University Hospital of Brest, Brest, France 33Henderson Research Centre 44Internal Medicine, McMaster University, Hamilton, Canada
How-to-cite Couturaud F, Duchemin J, Quere G, Kearon C, Ginsberg J, Leroyer C, Mottier D, Abgrall J. Elevated thrombin generation in relatives of patients with unprovoked venous thromboembolism and no detectable thrombophilia. Journal of Thrombosis and Haemostasis 2009; Volume 7, Supplement 2: Abstract PP-MO-310
Introduction: Patients with a first episode of unprovoked venous thromboembolism (VTE) in the absence of a detectable thrombophilia may have hereditary thrombophilias that have yet to be discovered. In a cross-sectional study, we aimed to compare thrombin generation in first degree relatives of patients with a first episode of unprovoked VTE according to whether those patients (index cases) have a detectable inherited thrombophilia or not.
Methods: Seventy-two index cases and their 385 first-degree relatives were tested for factor V Leiden, the G20210A prothrombin gene mutation and thrombin generation. In addition, the thrombin generation test was performed in 35 blood donor volunteers. The normalized thrombomodulin sensitivity ratio (n-TMsr) was defined as the ratio of endogenous thrombin potential determined in the presence and absence of thrombomodulin which was normalized against the same ratio determined in normal control plasma.
Results: The mean n-TMsr was 1.56 (± 0.63) in the 102 relatives of index cases with detectable thrombophilia (group T+), 1.39 (± 0.56) in the 278 relatives of index cases without detectable thrombophilia (group T-) and 1.0 (± 0.33) in the 35 blood donors (group C) (T+/T-: P = 0.04; T+/C and T-/C: P < 0.001). In the 20 relatives with previous VTE, 9 were unprovoked (mean n-TMsr 1.71 (± 0.23)) and 11 were provoked (mean n-TMsr 1.1 (± 0.21)) (P = 0.05, after adjustment on the presence or not of detectable thrombophilia in relatives).
Conclusions: Patients with unprovoked VTE and no detectable thrombophilia are likely to have thrombophilia that have yet to be discovered.
Disclosure of interest: none declared.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
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