THE QUALITY OF ANTICOAGULATION ON FUNCTIONAL OUTCOME AND MORTALITY FOR TIA/STROKE IN ATRIAL FIBRILLATION PATIENTS

Abstract number: P-W-572

Poli¹ D., Antonucci¹ E., Fatini¹ C., Ciucciarelli¹ L., Sticchi² E., Corsi¹ A., Abdullahi Said¹ A., Abbate¹ R., Gensini² G., Prisco¹ D.

¹¹Dept of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliero-Universitaria, Azienda Ospedaliero-Universitaria Careggi, Florence ²²Dept of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliero-Universitaria, Don Carlo Gnocchi Foundation, ONLUS IRCCS, Florence, Italy

How-to-cite Poli D, Antonucci E, Fatini C, Ciucciarelli L, Sticchi E, Corsi A, Abdullahi Said A, Abbate R, Gensini G, Prisco D. THE QUALITY OF ANTICOAGULATION ON FUNCTIONAL OUTCOME AND MORTALITY FOR TIA/STROKE IN ATRIAL FIBRILLATION PATIENTS. J Thromb Haemost 2007; 5 Supplement 2: P-W-572

Abstract

Introduction: In AF patients stroke is nearly twice as likely to be fatal as non-AF patients and functional deficits are more likely to be severe among survivors. The incidence of stroke among AF patients is greatly reduced by OAT. However, fluctuation of anticoagulation levels is intrinsically related to OAT and often INR is out of the therapeutic range

Methods: Since the "anticoagulation history" is an ongoing process, we performed this prospective study in 578 AF patients to investigate the role of the whole quality of OAT and of INR levels at the occurrence of TIA/stroke on the severity of cerebral ischemia

Results: During follow-up 13 patients had TIA and 18 had stroke (rate 1.67 x100 pt/yrs). In relation to the quality of anticoagulant treatment, no significant differences were found in the time spent below and within the intended therapeutic range, between patients with and without TIA/stroke. Patients with TIA/stroke spent a longer time above the intended therapeutic range with respect to other patients, even if this difference was not confirmed at multivariate analysis. occurrence of ischemic event.

Conclusions: In conclusion the severity of stroke was not related to the whole quality of anticoagulation or to INR at the event.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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