B-GROUP VITAMINS' PROFILE AND OCCURRENCE OF CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY

Abstract number: P-W-561

Sofi¹ F., Gori¹ A., Marcucci¹ R., Lucarini¹ L., Rogolino¹ A., Romano¹ E., Del Pace¹ S., Casini² A., Abbate¹ R., Gensini¹ G.

¹¹Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi ²²Clinical Pathophysiology, Unit of Clinical Nutrition, University of Florence, Florence, Italy

How-to-cite Sofi F, Gori A, Marcucci R, Lucarini L, Rogolino A, Romano E, Del Pace S, Casini A, Abbate R, Gensini G. B-GROUP VITAMINS' PROFILE AND OCCURRENCE OF CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY. J Thromb Haemost 2007; 5 Supplement 2: P-W-561

Abstract

Introduction: Dietary habits have long been reported to act a primary role on the occurrence of coronary artery disease (CAD). Aim of this study was to assess the dietary profile of a group of patients with CAD who underwent percutaneous coronary intervention with respect to a sex- and age-matched group of healthy subjects.

Methods: Dietary questionnaire, physical examination and blood withdrawal were performed in 104 patients with CAD (98 M, 11 F) and in a group of 312 age- and gender-matched healthy subjects (279 M; 33 F) enrolled in an epidemiologic study conducted in Florence, Italy between 2002 and 2004. Biochemical measurements included B-group circulating vitamins, and homocysteine.

Results: Homocysteine plasma levels were found to be higher in patients compared to healthy subjects [14.8 (6.6-97) vs 10.9 (5.6-70.6) mmol/L p<0.0001]. Both serum folate and vitamin B6 levels were higher in healthy subjects than in patients (5.75 2.67 vs. 4.43 3.34 ng/mL, p<0.0001; 14.48 5.69 vs. 7.39 3.39 mg/L p<0.0001, respectively), while there was no difference in vitamin B12 concentrations. Folate and vitamin B6 intakes were higher in healthy subjects than in patients (folic acid: 373.02 130.25 mg/die vs 314 116.51 mg/die; p<0.0001) (vitamin B6: 1.78 0.54 vs. 1.74 1.36; p=0.009). By dividing the study population into tertiles of circulating vitamins according to their distribution in the control group a regression analysis showed that low serum folate (<4.5 ng/mL) and vitamin B6 (<8.3 mg/L) were independent risk factors for CAD, after adjustment for dietary intakes and homocysteine [OR: 3.11 (1.49-6.49) and 3.06 (1.48-6.31)].

Conclusions: High levels of homocysteine and low circulating levels of B-group vitamins are significantly associated with an increased risk of CAD.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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