HEMORHEOLOGICAL PROFILE IN RETINAL VEIN OCCLUSION
Abstract number: P-W-522
Sofi1 F., Bolli2 P., Marcucci1 R., Alessandrello Liotta1 A., Lenti1 M., Abdihakim1 A., Mannini1 L., Abbate1 R., Gensini3 G., Prisco1 D.
11Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi 22Don Carlo Gnocchi Foundation, Onlus IRCCS 33Medical and Surgical Critical Care, Thrombosis Centre, Don Carlo Gnocchi Foundation, Florence, Italy
How-to-cite Sofi F, Bolli P, Marcucci R, Alessandrello Liotta A, Lenti M, Abdihakim A, Mannini L, Abbate R, Gensini G, Prisco D. HEMORHEOLOGICAL PROFILE IN RETINAL VEIN OCCLUSION. J Thromb Haemost 2007; 5 Supplement 2: P-W-522
Abstract
Introduction: Retinal vein occlusion (RVO) represents the second commonest vascular disease of the eye. Hyperviscosity, due to alterations of blood cells and plasma components, may play a role in the pathogenesis of the disease. Aim of this study was to evaluate the possible association between hemorheological variables and RVO.
Methods: The hemorheologic variables [whole blood viscosity (WBV), erythrocyte deformability index (DI), plasma viscosity (PLV), fibrinogen] were analyzed in 180 patients (median age: 66.5, range 26-84; 78 M, 102 F] and in 180 healthy subjects comparable for age and gender. WBV and PLV were measured using a Rotational Viscosimeter (Contraves, Switzerland), EF was measured by a microcomputer-assisted filtrometer (Myrenne, Germany).
Results: WBV at 0.512s-1 and 94.5s-1 shear rates and EF, but not PLV, were found to be significantly different in patients as compared to healthy subjects. In order to investigate the possible association between these parameters and the disease we divided the study population into tertiles of their distribution among the healthy control group. At the univariate analysis, we found a significant association between the highest tertiles of WBV at shear rate 94.5 cycles s-1 (OR: 4.91, 95%CI 2.95-8.17; p<0.0001), WBV at shear rate 0.512 cycles s-1 (OR: 2.31, 95%CI 1.42-3.77; p<0.0001), and erythrocyte deformability (OR: 0.18, 95%CI 0.10-0.32; p<0.0001) and the disease. At multivariate analysis, the highest tertiles of WBV at shear rate 0.512 cycles s-1 (OR:3.23, 95%CI 1.39-7.48; p=0.006), WBV at shear rate 94.5 cycles s-1 (OR: 6.74, 95%CI 3.06-14.86; p<0.0001) and DI (OR: 0.20, 95%CI 0.09-0.44, p<0.0001) remained to be significantly associated with the disease, as compared to the lowest tertile.
Conclusions: Our data indicate that an alteration of hemorheologic parameters, namely WBV and DI, may modulate the susceptibility to the RVO. Hemorheological profile could allow to identify patients who might benefit from hemodilution.
