THE PROTECTIVE EFFECT OF FXIII VAL34LEU POLYMORPHISM AGAINST VENOUS THROMBOSIS IN IRANIAN PATIENTS
Abstract number: P-W-514
Sajadi1 S., Samiei2 S., Kheirandish3 M., Ataiei2 Z., Kavari2 M., Abdollahi2 M., Tootian2 S., Soheily4 Z., Tabatabaie1 S., Meshkani5 R., Sharifi6 Z., Jalali Far7 M.
11Coagulation, Iranian Blood Transfusion Organization Research Center 22PCR lab 33flowcytometry, IBTO Research Center 44PCR lab., IBTO Research Center 55Biochemistry, pastur institute 66PCR lab., Iranian Blood Transfusion Organization Research Center, Tehran 77Q.C manager, IBTO Research Center, Ahwaz, Iran (Islamic Republic of)
How-to-cite Sajadi S, Samiei S, Kheirandish M, Ataiei Z, Kavari M, Abdollahi M, Tootian S, Soheily Z, Tabatabaie S, Meshkani R, Sharifi Z, Jalali Far M. THE PROTECTIVE EFFECT OF FXIII VAL34LEU POLYMORPHISM AGAINST VENOUS THROMBOSIS IN IRANIAN PATIENTS. J Thromb Haemost 2007; 5 Supplement 2: P-W-514
Abstract
Introduction: It has been suggested that a G T transition in exon 2 of the FXIIIA gene resulting in a substitution of luecine for valine of amino acid 34 (FXIII Val34Leu polymorphism) protects against venous thrombosis, In addition, FXIII Val34Leu polymorphism has a significant heterogenity, However, the evidence to date is insufficient to incorporate testing for the FXIII Val34Leu variant in to clinical practice. The aim of this case-control study was to investigate the first national prevalence and the role of FXIII Val34Leu polymorphism in venous thrombosis
Methods: 214 patients with venous thrombosis and 100 age and sex matched healthy controls were genotyped for the FXIII Val34Leu polymorphism. FXIII Val34Leu genotypes were determined by use of PCR – RFLP method.the data analysed by using SPSS 11.5 (chi square and odd ratio)
Results: FXIII Val34Leu polymorphism was found significantly more often in control subjects than in patients with venous thrombosis (37.4% vs 24.3%) with a
Pv: 0.017 and an odds ratio of 1.859 (95% confidence interval:1.113-3.106). There was no different between Val/Val genotype (wild type) in cases and controls. In addition, the prevalence of Leu allele was significantly higher in controls (20.2% vs 13.3%) with a Pv: 0.027 and odds ratio of 1.648 (confidence interval: 1.056-2.572)
Conclusions: Because prevalence of leucine allele was significantly higher in controls, we concluded that the presence of FXIII Val34Leu polymorphism is associated with a protective effect against venous thrombosis.
