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A 2 ADENINE INSERTION POLYMORPHISM IN THE FVII GENE 3'UTR IS ASSOCIATED WITH PERIPHERAL ARTERIAL DISEASE BUT NOT WITH VENOUS THROMBOSIS: RESULTS OF CASE-CONTROL STUDIES
Abstract number: P-W-492
Serve1 E., Reny2 J.L., Akhavan1 S., Emmerich3 J., Fischer1 A.M., Tapon-Bretaudière1 J.
11Laboratoire d'hématologie, Hôpital Georges Pompidou, INSERM U765, Université Paris-Descartes, Paris 22Département de médecine interne, Centre hospitalier, Béziers 33Service de médecine vasculaire, Hôpital Georges Pompidou, INSERM U765, Université Paris-Descartes, Paris, France
How-to-cite Serve E, Reny JL, Akhavan S, Emmerich J, Fischer AM, Tapon-Bretaudière J. A 2 ADENINE INSERTION POLYMORPHISM IN THE FVII GENE 3'UTR IS ASSOCIATED WITH PERIPHERAL ARTERIAL DISEASE BUT NOT WITH VENOUS THROMBOSIS: RESULTS OF CASE-CONTROL STUDIES. J Thromb Haemost 2007; 5 Supplement 2: P-W-492
Abstract
Introduction: Polymorphic variants of genes encoding blood coagulation proteins have been extensively studied as risk factors for venous or arterial thrombosis. A variation in the 3' untranslated region (UTR) involved in the post-transcriptional regulation of FVII gene has been recently identified, the insertion/deletion of two adenine.
Methods: In this study, we investigated its effect on the risk of thrombosis in the frame of two case-control studies, including patients suffering respectively from peripheral arterial disease (PAD) or venous thromboembolic (VTE) disease. The 3'UTR F7 polymorphism was investigated (i) in 181 patients who had symptomatic atherosclerotic disease of the lower limbs, (ii) in 178 patients who had had at least one episode of objectively diagnosed deep venous thrombosis and (iii) in controls.
Results: FVII:Ag levels were significantly lower in the presence of the 3'UTR 2A insertion (68.412.3, 81.314.5 and 89.513.7% in 2A/2A, 2A/0 and 0/0 subjects respectively, p<0.0001). No significant relationship was found with VTE disease but the association of this polymorphism with PAD was significant after adjustment for traditional risk factors (hypercholesterolemia, smoking status, diabetes and hypertension), with an OR of 0.24 [95% CI 0.06-0.99].
Conclusions: The 2 adenine insertion in the 3'UTR of FVII gene is associated with reduced plasma FVII levels and a lower risk of peripheral arterial disease.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
Session Details
| Date: |
01/08/2007
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| Time: |
00:00-00:00
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| Session name: |
XXIst ISTH Congress |
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| Location: |
Oxford, UK |
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