FISH INTAKE AND LPA 93CT POLYMORPHISM: GENE-ENVIRONMENT INTERACTION IN MODULATING LIPOPROTEIN (A) CONCENTRATIONS

Abstract number: P-W-488

Sofi¹ F., Fatini¹ C., Sticchi² E., Lenti¹ M., Gori¹ A., Giusti¹ B., Fedi¹ S., Casini³ A., Abbate¹ R., Gensini² G.

¹¹Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi ²²Don Carlo Gnocchi Foundation, Onlus IRCCS ³³Clinical Pathophysiology, Unit of Clinical Nutrition, University of Florence, Florence, Italy

How-to-cite Sofi F, Fatini C, Sticchi E, Lenti M, Gori A, Giusti B, Fedi S, Casini A, Abbate R, Gensini G. FISH INTAKE AND LPA 93CT POLYMORPHISM: GENE-ENVIRONMENT INTERACTION IN MODULATING LIPOPROTEIN (A) CONCENTRATIONS. J Thromb Haemost 2007; 5 Supplement 2: P-W-488

Abstract

Introduction: High plasma lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for atherosclerotic diseases. To date, no effective intervention strategies on reducing Lp(a) concentrations have been reported. Aim of the study was to evaluate the possible modulation of 2 polymorphisms of LPA gene (LPA 93C>T and LPA 121G>A) and nutritional habits on Lp(a) concentrations.

Methods: We studied 647 healthy Italian subjects (260 M; 387 F) with a median age of 48 years (range: 19-78) enrolled in an epidemiological study conducted in Florence, Italy between 2002 and 2004.

Results: A linear regression analysis showed a significant negative influence of fish intake (b = - 0.174 0.084; P=0.04) on Lp(a) concentrations, after adjustment for smoking habit, C-reactive protein serum concentrations, dietary habits and LDL-cholesterol concentrations. With regard to LPA polymorphisms, LPA 93C>T polymorphism resulted to significantly affect Lp(a) circulating concentrations in a dose-dependent manner, with lower concentrations showed by subjects carrying the T rare allele. No significant influence of LPA 121G>A polymorphism on Lp(a) concentrations was observed. Moreover, by analysing the possible interplay between LPA 93C>T and dietary fish intake, a significant interaction between these two determinants in lowering Lp(a) concentrations was observed. Lower Lp(a) concentrations were observed in subjects carrying the T allele of the LPA 93C>T polymorphism and consuming a high intake of fish with respect to those being in the highest tertile of fish consumption but homozygotes for the common allele of the polymorphism.

Conclusions: In conclusion, this study reported a significant interaction of daily fish intake and LPA 93C>T polymorphism in decreasing Lp(a) concentrations.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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