ENDOGENOUS THROMBIN POTENTIAL IN PATIENTS WITH IDIOPATHIC VENOUS THROMBOSIS

Abstract number: P-W-045

Lo Coco¹ L., Malato¹ A., Deidda¹ I., Cigna¹ V., Saccullo¹ G., Anastasio¹ R., Abbene¹ I., Curiale¹ S., Abbadessa¹ V., Siragusa¹ S.

¹Thrombosis Haemostasis and Haematology Unit, University Hospital of Palermo, Palermo, Italy

How-to-cite Lo Coco L, Malato A, Deidda I, Cigna V, Saccullo G, Anastasio R, Abbene I, Curiale S, Abbadessa V, Siragusa S. ENDOGENOUS THROMBIN POTENTIAL IN PATIENTS WITH IDIOPATHIC VENOUS THROMBOSIS. J Thromb Haemost 2007; 5 Supplement 2: P-W-045

Abstract

Introduction: Many parameters of the haemostasis are currently tested to identify potential causes of congenital or acquired thrombosis. The role of single global tests, such as Endogenous Thrombin Potential (ETP), has not been yet established for this purpose.

Methods: We prospectively investigated 104 consecutive patients with proven idiopathic Venous Thrombosis (VT) and 127 as control. All patients were tested for Factor V Leiden (FVL), Factor II G 20210A (FII), FVIII, Protein C (PC), Protein S (PS), AntiThrombin (AT), Resistance to Activated Protein C (APC-R), Lupus AntiCoagulant(LAC), D-dimer and ETP (Dade Behring). ETP value was obtained from the aerea under the thrombin generation curve, automatically calculated. High ETP was calculated using the 90th percentiles of control subjects (ETP > 400 mA) as a cut-off point. Testing was done after suspension of anticoagulant therapy.

Results: Thrombophilic testing was performed off anticoagulation, after a median time from index venous thrombosis of 4.6 months. The rates of abnormal thrombophilic factors in patients with thrombosis and in controls are reported and related odds ratios in the table.

Table:

	Cases (104), n (%)	Controls (127), n (%)	Odds Ratio (95% CI)
APC-Resistance	25, (24)	6, (4.7)	5.1 (2.1-8.2)
Low PS	2 (1.9)	0	–
Low PC	5, (4.8)	1, (0.8)	6 (2.6-8.4)
Low AT	0	0	–
High LAC	33, (31.7)	11, (8.7)	3.6 (0.6-6.6)
High FVIII	18, (17.3)	9, (7)	2.4 (0.3.4.5)
Mutated FVL	23, (22)	6, (4.7)	4.6 (1.1- 8.1)
Mutated FII	14, (13.4)	4, (3.1)	4.3 (2.1-6.5)
High D-dimer	32, (30.7)	3, (2.3)	13.3 (3.4-23.2)
High ETP	38, (36.5)	2, (1.5)	24.3 (15.6-33)
APC (Activated Protein C), FV (Factor V), FII (Factor II).

Conclusions: In the current study, we demonstrated that high ETP concentrations are frequent in patients with idiopathic VT and determine high odds ratio. Future research will focus on thrombin generation tests for predicting risk of recurrence.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
Back to top

| ISTH 2009