SOLUBLE P-SELECTIN AND THE RISK OF THROMBOTIC EVENTS IN PATIENTS WITH A LUPUS ANTICOAGULANT IN A PROSPECTIVE COHORT STUDY

Abstract number: P-W-021

Vormittag¹ R., Panzer² S., Ay¹ C., Quehenberger³ P., Koder¹ S., Pabinger¹ I.

¹¹Internal Medicine I ²²Clinic for Blood Group Serology ³³Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria

How-to-cite Vormittag R, Panzer S, Ay C, Quehenberger P, Koder S, Pabinger I. SOLUBLE P-SELECTIN AND THE RISK OF THROMBOTIC EVENTS IN PATIENTS WITH A LUPUS ANTICOAGULANT IN A PROSPECTIVE COHORT STUDY. J Thromb Haemost 2007; 5 Supplement 2: P-W-021

Abstract

Introduction: Increased soluble P-selectin (sP-selectin) was associated with an about 10-fold increased risk of recurrent venous thromboembolism in a case/control study. Elevated sP-selectin levels were reported in patients with a lupus anticoagulant (LA-patients). We aimed to assess the role of sP-selectin as risk predictor of thrombosis in LA-patients.

Methods: Diagnosis of LA was made according to established criteria. sP-selectin was determined by ELISA (Human soluble P-Selectin Immunoassay, R&D Systems, Minneapolis, USA). LA-patients were followed in a prospective cohort study. A Hazard ratio for thrombosis was calculated by multivariate cox regression analysis.

Results: Ninety-seven LA-patients were included (80 women, 17 men; median age 42, range 17–86 years). Sixty-nine LA-patients with a history of thrombotic events (59 women, 10 men) had significantly higher sP-selectin levels (p-selectin median 44.1 ng/ml, range 9.8–130.1) than the remaining 28 LA-patients without a history of thrombotic events (21 women, 7 men, median 35.5 ng/ml, range 15.6–74.1, p=0.007). During follow-up (median observation time: 911 days, range: 80–1973) 10 thrombotic events were observed (4 deep vein thromboses, 1 pulmonary embolism, 3 strokes, 2 myocardial infarction). A sP-selectin level above 55.1 ng/ml (=95th percentile of 129 healthy individuals) was present in 25 patients and was associated with a hazard ratio for thrombosis of 2.0 [95% confidence interval: 0.5–8.2, p=0.34] adjusted for age, sex, oral anticoagulation and positive thrombosis history in cox regression analysis.

Conclusions: Higher sP-selectin levels were associated with a history of thrombosis in LA-patients. Whether high p-selectin levels qualify as a predictive parameter for thrombosis in LA-patients needs confirmation.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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