SOLUBLE P-SELECTIN AND THE RISK OF THROMBOTIC EVENTS IN PATIENTS WITH A LUPUS ANTICOAGULANT IN A PROSPECTIVE COHORT STUDY
Abstract number: P-W-021
Vormittag1 R., Panzer2 S., Ay1 C., Quehenberger3 P., Koder1 S., Pabinger1 I.
11Internal Medicine I 22Clinic for Blood Group Serology 33Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
How-to-cite Vormittag R, Panzer S, Ay C, Quehenberger P, Koder S, Pabinger I. SOLUBLE P-SELECTIN AND THE RISK OF THROMBOTIC EVENTS IN PATIENTS WITH A LUPUS ANTICOAGULANT IN A PROSPECTIVE COHORT STUDY. J Thromb Haemost 2007; 5 Supplement 2: P-W-021
Introduction: Increased soluble P-selectin (sP-selectin) was associated with an about 10-fold increased risk of recurrent venous thromboembolism in a case/control study. Elevated sP-selectin levels were reported in patients with a lupus anticoagulant (LA-patients). We aimed to assess the role of sP-selectin as risk predictor of thrombosis in LA-patients.
Methods: Diagnosis of LA was made according to established criteria. sP-selectin was determined by ELISA (Human soluble P-Selectin Immunoassay, R&D Systems, Minneapolis, USA). LA-patients were followed in a prospective cohort study. A Hazard ratio for thrombosis was calculated by multivariate cox regression analysis.
Results: Ninety-seven LA-patients were included (80 women, 17 men; median age 42, range 1786 years). Sixty-nine LA-patients with a history of thrombotic events (59 women, 10 men) had significantly higher sP-selectin levels (p-selectin median 44.1 ng/ml, range 9.8130.1) than the remaining 28 LA-patients without a history of thrombotic events (21 women, 7 men, median 35.5 ng/ml, range 15.674.1, p=0.007). During follow-up (median observation time: 911 days, range: 801973) 10 thrombotic events were observed (4 deep vein thromboses, 1 pulmonary embolism, 3 strokes, 2 myocardial infarction). A sP-selectin level above 55.1 ng/ml (=95th percentile of 129 healthy individuals) was present in 25 patients and was associated with a hazard ratio for thrombosis of 2.0 [95% confidence interval: 0.58.2, p=0.34] adjusted for age, sex, oral anticoagulation and positive thrombosis history in cox regression analysis.
Conclusions: Higher sP-selectin levels were associated with a history of thrombosis in LA-patients. Whether high p-selectin levels qualify as a predictive parameter for thrombosis in LA-patients needs confirmation.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
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