ASSOCIATION BETWEEN PLASMA LEVELS OF HOMOCYSTEINE (HCY) AND SMOKING IN PERIPHERAL ARTERIAL OBSTRUCTIVE DISEASE (PAOD)

Abstract number: P-T-616

Mota¹ A.P.L., Santos² M.E.R.C., Fernandes¹ A.P.S.M., Silva² F.C.L., Carvalho¹ M.G.

¹¹Faculty of Farmacy, Federal University of Minas Gerais ²²Vascular Surgery Department, Hospital Santa Casa de Misericordia, Belo Horizonte, Brazil

How-to-cite Mota APL, Santos MERC, Fernandes APSM, Silva FCL, Carvalho MG. ASSOCIATION BETWEEN PLASMA LEVELS OF HOMOCYSTEINE (HCY) AND SMOKING IN PERIPHERAL ARTERIAL OBSTRUCTIVE DISEASE (PAOD). J Thromb Haemost 2007; 5 Supplement 2: P-T-616

Abstract

Introduction: PAOD is one of the manifestations of systemic atherosclerosis and is associated to several risk factors including smoking and hyperhomocysteinemia. Smoking is considered as one of the most important factors for development of PAOD and increased plasma levels of Hcy have been related to smoking. The aim of this study was to investigate if PAOD is associated to higher levels of Hcy and smoking and if both are associated between themselves.

Methods: Plasma levels of Hcy were measured in two groups, including 39 patients with PAOD (group 1) and 32 without PAOD (group 2), selected from Hospital Santa Casa de Misericordia, Belo Horizonte, Minas Gerais, Brazil. It was conducted a survey on the number of smokers among the participants of this study, as well as time of smoking and/or time of cessation of tabacco use.

Results: Significant differences were found (t-student Test, p<0,05) for the levels of Hcy between group 1 (mean=15,38umoL/L) and group 2 (mean=10,81umoL/L). A trend for developing PAOD among smokers was observed, considering that 71,8% of the patients were also smokers (Chi-square, p=0,0001). Higher plasma levels of Hcy in patients with PAOD were significantly associated to smoking (Chi-square, p<0,05). It was observed significant difference between the groups considering PAOD presence and smoking.

Conclusions: The date taken together show that PAOD is closely associated to higher levels of Hcy and/or smoking in Brazil, as well as higher levels of Hcy are associated to smoking. In addition, it was also observed that the effect of tabacco use has persisted even after interruption of this habit.

Acknowledgements: Supported by FAPEMIG/CNPq, Brazil

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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