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ELEVATED D-DIMER LEVELS IN PATIENTS WITH DEEP VEIN THROMBOSIS
Abstract number: P-T-523
Matsumoto1 T., Wada2 H., Abe3 Y., Kobayashi4 T., Yamada5 N., Nobori2 T.
11Hematology, Mie University Hospital 22Molecular and Laboratory Medicine, Mie University Graduate School of Medicine 33Central Laboratory, Mie University Hospital 44Hematology 55Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
How-to-cite Matsumoto T, Wada H, Abe Y, Kobayashi T, Yamada N, Nobori T. ELEVATED D-DIMER LEVELS IN PATIENTS WITH DEEP VEIN THROMBOSIS. J Thromb Haemost 2007; 5 Supplement 2: P-T-523
Abstract
Introduction: D-dimer levels are considered to be useful in the diagnosis of thrombosis, and are reported to be elevated in deep vein thrombosis (DVT)/pulmonary embolism (PE) and other various thrombotic diseases, however the evidence for the diagnosis of thrombosis by D-dimer levels is not well established. The present study was designed to evaluate the cutoff values of D-dimer in the diagnosis of thrombosis.
Methods: Plasma concentrations of D-dimer were measured in 376 inpatients suspected to have some thrombosis, correlated with diagnosed thrombosis and 100 healthy volunteers. Differences between groups were examined for statistical significance using the Mann-Whitney's U test while correlation between two variables was tested by Pearson's correlation analysis. The usefulness of D-dimer levels in the diagnosis of thrombosis and DVT or PE was examined by ROC analysis. Plasma concentrations of D-dimer were measured by the new DD assay (VIDAS D-Dimer EXCLUSION, bioMerieux, Marcy l'Etoile, France), which was a quantitative ELISA method automated on a VIDAS immunoanalyzer.
Results: Plasma D-dimer concentrations were significantly higher in 167 patients with thrombosis than those without thrombosis. There is no significant difference in D-dimer levels among various thromboses such as PE/DVT and disseminated intravascular coagulation (DIC). ROC analysis showed that D-dimer levels were useful in the diagnosis of various thromboses, especially DVT/PE. The cutoff value was 2,200 ng/ml, and it was 450 ng/ml for all thromboses and 1,050 ng/ml for DVT/PE to keep the high value of NPV (more than 99%).
Conclusions: Elevated D-dimer levels indicate a high risk for thrombosis, especially DVT/PE, and are useful for the diagnosis of thrombosis.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
Session Details
| Date: |
01/08/2007
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| Time: |
00:00-00:00
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| Session name: |
XXIst ISTH Congress |
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| Location: |
Oxford, UK |
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