THROMBOPHILIA IS FREQUENT IN SUPERFICIAL VEIN THROMBOSIS AND IS ASSOCIATED WITH RECURRENCE
Abstract number: P-T-520
Marcucci1 R., Ciuti1 G., Poli1 D., Lenti1 M., Blagojevic1 E., Falciani1 M., Abdullahi1 A., Gensini2 G., Abbate1 R., Prisco1 D.
11Surgical and Medical Critical Area 22Don Carlo Gnocchi Foundation, University of Florence, Florence, Italy
How-to-cite Marcucci R, Ciuti G, Poli D, Lenti M, Blagojevic E, Falciani M, Abdullahi A, Gensini G, Abbate R, Prisco D. THROMBOPHILIA IS FREQUENT IN SUPERFICIAL VEIN THROMBOSIS AND IS ASSOCIATED WITH RECURRENCE. J Thromb Haemost 2007; 5 Supplement 2: P-T-520
Abstract
Introduction: Superficial vein thrombosis (SVT) is a common disease and the recent recognition of its association with venous thromboembolism has revived the interest in this disease. Aim of our study was to determine the thrombophilic risk profile of patients with SVT by evaluating: Factor V Leiden, prothrombin polymorphism, physiological clotting inhibitors, antiphospholipid antibodies, homocysteine, plasminogen activator inhibitor-1 (PAI-1) and lipoprotein (a).
Methods: The study population consisted of 183 patients (138 F/45 M; age 42 (15-74) yrs) and 183 age and sex matched (138 F/45 M; age 42 (15-74) yrs) controls.
Results: At the multivariate analysis adjusted for age, sex, circumstantial and thrombophilic risk factors, independent risk factors for SVT were: factor V Leiden (OR 12.3 (95% CI 5.0-30.2), p<0.000); hyperhomocysteinemia (OR 6.2 (95% CI 2.8-13.7), p<0.000); antiphospholipid antibodies (OR 5.1 (95% CI 1.6-16.4), p<0.006) and prothrombin polymorphism (OR 3.5 (95% CI 10.1-12.5), p<0.000). 106 patients (57.9%) had at least one recurrence of venous thromboembolism (either SVT or DVT). At the multivariate analysis, independent risk factors for recurrences were: hyperhomocysteinemia (OR 4.2 (95% CI 1.6-11), p<0.003); factor V Leiden (OR 2.5 (95% CI 1.1-5.7), p<0.002) and the occurrence of a first idiopathic episode (OR 2.0 (95% CI 1.05-4.1), p<0.002). Thirthy-four out of 183 (13.1%) had a DVT after the first SVT. At the multivariate analysis, independent risk factor for a second episode of deep vein thrombosis were: prothrombin polymorphism (OR 12.6 (95% CI 2.9-53.9), p<0.001) and hyperhomocysteinemia (OR 4.6 (95% CI 1.7-12.6), p<0.003).
Conclusions: Our findings indicate that a thrombophilic state is frequent in patients with SVT. We demonstrated that factor V Leiden, hyperhomocysteinemia and prothrombin polymorphism are independent risk factors for recurrences. These alterations allow us to identify patients at high risk of recurrences and of DVT.
