A HIGH PLATELET COUNT INDEPENDENTLY PREDICTS VENOUS THROMBOEMBOLISM IN CANCER PATIENTS

Abstract number: P-T-497

Simanek¹ R., Vormittag¹ R., Alguel¹ G., Ay¹ C., Dunkler² D., Quehenberger³ P., Zielinski¹ C., Jaeger¹ U., Pabinger¹ I.

¹¹Internal Medicine I ²²Core Unit for Statistics ³³Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria

How-to-cite Simanek R, Vormittag R, Alguel G, Ay C, Dunkler D, Quehenberger P, Zielinski C, Jaeger U, Pabinger I. A HIGH PLATELET COUNT INDEPENDENTLY PREDICTS VENOUS THROMBOEMBOLISM IN CANCER PATIENTS. J Thromb Haemost 2007; 5 Supplement 2: P-T-497

Abstract

Introduction: Cancer patients are at increased risk of venous thromboembolism (VTE), laboratory parameters with predictive value could help to assign a patient to a high or low risk group. We aimed to assess high platelet count as thrombosis risk predictor.

Methods: CATS is an ongoing prospective observational study in patients with newly diagnosed cancer or progression of disease, enrolment started 10/2003. Occurrence of VTE and information on the patients' anti-cancer-treatment within the follow up period are recorded. VTE has always been confirmed by imaging. Observation ends with occurrence of VTE, death or after 2 years. Kaplan Meier and Cox regression analysis were applied for statistical calculation.

Results: We included 489 patients (243 female/246 male, median age 63 yrs) with solid tumours. Main tumour entities were malignancies of the breast, lung, upper and lower gastrointestinal tract, pancreas and prostate. Distant metastases were found in 256 patients at recruitment. During the observation period VTE occurred in 27 patients (13 female/14 male, median age 62 yrs.). The cumulative probability of VTE was 6.2% after one year. High platelet count (above 459 G/l = 95th percentile) [HR: 4.9, 95% CI 1.9-12.4], surgery [HR: 6.8, 95% CI 2.6-17.9] and radiotherapy [HR: 3.2, 95% CI 1.2-8.4] were statistically significant risk factors for VTE in multivariate analysis including platelet count, age, sex, distant metastases, surgery, chemotherapy and radiotherapy.

Conclusions: High platelet count is a clinically important independent predictive parameter for VTE in cancer patients.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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