ASSOCIATION OF C-REACTIVE PROTEIN AND WHITE BLOOD CELL COUNT WITH PHYSICAL ACTIVITY IN HEALTHY SUBJECTS
Abstract number: P-T-467
Zito1 F., Plescia1 E., Costanzo1 S., Di Castelnuovo1 A., Arcari1 A., Centritto1 F., De Curtis1 A., De Lucia1 F., di Giuseppe1 R., Di Stefano1 I., Magnacca1 S., Pampuch1 A., Persichillo1 M., Rago1 L., Silvestri1 C., Vohnout1 B., Donati1 M.B., de Gaetano1 G., Iacoviello1 L.
1Research Laboratories, Catholic University, Campobasso, Italy
How-to-cite Zito F, Plescia E, Costanzo S, Di Castelnuovo A, Arcari A, Centritto F, De Curtis A, De Lucia F, di Giuseppe R, Di Stefano I, Magnacca S, Pampuch A, Persichillo M, Rago L, Silvestri C, Vohnout B, Donati MB, de Gaetano G, Iacoviello L. ASSOCIATION OF C-REACTIVE PROTEIN AND WHITE BLOOD CELL COUNT WITH PHYSICAL ACTIVITY IN HEALTHY SUBJECTS. J Thromb Haemost 2007; 5 Supplement 2: P-T-467
Introduction: We investigated the association between physical activity (PA) and CRP and WBC count in men and women at different age.
Methods: The Moli-sani Project is an ongoing cohort study on subjects aged >=35 yrs, randomly recruited from the general population of a Southern Italian region. After exclusion of subjects with CVD (5%) and incomplete questionnaires (13%), 3,485 females and 3,071 males were cross-sectionally analyzed. PA was assessed by a structured questionnaire (24 questions on working and leisure time). Weekly energy expenditure in metabolic equivalent task-hours (MET-h) and age were were calculated in tertiles. CRP levels were measured by immunoturbidimetric method (IL, Milan, Italy).
Results: Correlation analysis (Pearson's test) showed inverse correlation between CRP and PA (p<0.0001), both in men and women. WBC count was inversely correlated with PA in men (p=0.016), but not in women (p=0.07). High PA was also associated with lower BMI, waist circumference, systolic and diastolic blood pressure, LDL, total cholesterol and triglycerides and higher HDL (p<0.001).
In multivariate regression analysis, CRP was still associated with PA in the younger (p=0.0154) and older (p=0.006) age tertiles in men and in the old age tertile (p=0.023) in women. WBC count remained positively associated with PA in the younger (p=0.018) and older (p=0.006) age group.
Conclusions: PA was associated with a better anti-inflammatory profile both in men and women and was dependent on age.
Supported by Fondazione Pfizer and Italian Research Ministry.