ANTIPHOSPHOLIPID ANTIBODIES AND THE ANTIPHOSPHOLIPID SYNDROME IN PATIENTS WITH SYSTEMIC LUPUS RYTHMATOSUS
Abstract number: P-T-437
Taouli1 K., Reghis2 R.A., Schved3 S.J.F., Boudghene Stambouli1 B.O., Hamidou1 S.R.
11Medecine, school medical university, Tlemcen 22Medecine, school medical university, Alger, Algeria 33Medecine, school medical university, Montpellier, France
How-to-cite Taouli K, Reghis RA, Schved SJF, Boudghene Stambouli BO, Hamidou SR. ANTIPHOSPHOLIPID ANTIBODIES AND THE ANTIPHOSPHOLIPID SYNDROME IN PATIENTS WITH SYSTEMIC LUPUS ÉRYTHÉMATOSUS. J Thromb Haemost 2007; 5 Supplement 2: P-T-437
Abstract
Introduction: Recent data strongly has suggest that phospholipids binding proteins are the physiologically relevant targets of antiphospholipid antibodies(aPL), the most common and best characterized proteins involved are Beta2Glycoproteine I(B2GPI).
Methods: We studied sixty patients with SLE and sixty two blood bank donors.
We tested Anticardiolipin antibodies (aCL)(IgG and IgM isotypes)and anti-B2 GPI by enzyme linked immuno-assay (ELISA), LA activity (LAC) using both diluted thromboplastine time and Staclot LA.
Results: Prevalence of aPL (40%)was increased in patients with SLE in comparaison to blood donors (p<0.001).
A combination of a positive aCL and anti-B2GPI ELISA better correlates with the clinical manifestations observed in APS (p<0.01).
In the univariate analysis,we confirmed LA and aCL to be related to vascular thrombosis (p<0.001).Anti-B2GPI both IgG and IgM correlated with venous thrombosis.
Multivariate logistic regression analysis of risk factors for vascular thrombosis, confirmed that the combination positive LAC,positive aPA IgG and anti-B2GPI-IgG was significant risk factor for vascular thrombosis (OR 6.39,95% confidence intervals 1-39)
Conclusions: The results showed that the triple positivite LA/anti-béta 2GPI-IgG/aPA-IgG correlates better with the risk for thrombosis than the positive LAC alone.
References: 1. Miyakis S, Lockshin MD, Atsumi T and al(2005). International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome.Journal of thrombosis and haemostasis, 3:1-12.
2. DeMoerloose P,Reber G(2004).Antiphospholipid antibodies: do we still need to perform anticardiolipin ELISA assays.Journal of thrombosis and haemostasis,2:1071-3.
3. Galli M,Luciani D,Bertolini G,Barbui T(2003).Anti-B2-Glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome. Blood, october;vol 102,15,8:2717-23.
4. Levine JS, Branch WD,Rauch J(2002).The antiphospholipid syndrome.The new England journal of Medicine,vol 346,10: 752-753
