PLATELET FUNCTION EVALUATION BY USING A NEW POINT-OF-CARE SYSTEM AND PLATELET LIGHT-TRANSMISSION AGGREGATION IN A LARGE COHORT OF CORONARY ARTERY DISEASE PATIENTS
Abstract number: P-T-348
Panicca1 R., Antonucci1 E., Romano1 E., Gori1 A., Marcucci1 R., Attanasio1 M., Poli1 S., Prisco1 D., Abbate1 R., Gensini2 G.
11Department of Medical and Surgical Critical Care, Thrombosis Center, Azienda Ospedaliero-Universitaria, Careggi, Florence 22Department of Medical and Surgical Critical Care, Thrombosis Center, Don Carlo Gnocchi, Foundation ONLUS IRCCS, Florence, Florence, Italy
How-to-cite Panicca R, Antonucci E, Romano E, Gori A, Marcucci R, Attanasio M, Poli S, Prisco D, Abbate R, Gensini G. PLATELET FUNCTION EVALUATION BY USING A NEW POINT-OF-CARE SYSTEM AND PLATELET LIGHT-TRANSMISSION AGGREGATION IN A LARGE COHORT OF CORONARY ARTERY DISEASE PATIENTS. J Thromb Haemost 2007; 5 Supplement 2: P-T-348
Abstract
Introduction: Coronary artery disease (CAD) patients on dual antiplatelet therapy with a residual platelet reactivity (RPR) may be at increased risk of ischemic vascular events. VerifyNow P2Y12 assay, a new point-of-care (POC) test, has been suggested as rapid tool to evaluate RPR in CAD patients on clopidogrel
Methods: We compared this POC system with light transmission aggregation (LTA) induced by 2 and 10 mM L ADP in 1267 CAD patients undergoing percutaneous coronary intervention and receiving dual antiplatelet therapy. Cut-off values for identifying RPR were defined on the basis of 5th percentile of normal distribution: 52% and 64% for 2 and 10 mM L ADP LTA and 244 Platelet Reaction Unit (PRU) for VerifyNow system
Results: RPR was detected in 16.9% patients by 2 mM ADP-LTA, in 29.2% by 10 mM ADP-LTA and in 30.5% by VerifyNow method. VerifyNow P2Y12 assay showed a significant correlation with LTA induced by 2 mM ADP (rho=0.62, p<0.001; concordant samples =74.5%, k=0.33, p<0.001) and with LTA induced by 10 mM (rho=0.63, p<0.001; concordant samples=75.7%, k=0.43, p<0.001). Considering 10 mmol/L ADP-LTA as the reference method for RPR, VerifyNow system showed a sensitivity of 63.3%, a specificity of 83.3%.
Conclusions: Our results show good significant correlations between POC system and LTA. Clinical validation studies for POC system are necessary
