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MAXIMAL AND LATE ADP INDUCED PLATELET AGGREGATION IN CORONARY ARTERY DISEASE PATIENTS ON DUAL ANTIPLATELET THERAPY
Abstract number: P-T-347
Panicca1 R., Antonucci1 E., Gori1 A., Marcucci1 R., Romano1 E., Rossi1 L., Claudia1 S., Prisco1 D., Abbate1 R., Gensini2 G.
11Department of Medical and Surgical Critical Care, Thrombosis Center, Azienda Ospedaliero-Universitaria, Careggi, Florence 22Department of Medical and Surgical Critical Care, Thrombosis Center, Don Carlo Gnocchi Foundation, ONLUS IRCCS, Florence, Florence, Italy
How-to-cite Panicca R, Antonucci E, Gori A, Marcucci R, Romano E, Rossi L, Claudia S, Prisco D, Abbate R, Gensini G. MAXIMAL AND LATE ADP INDUCED PLATELET AGGREGATION IN CORONARY ARTERY DISEASE PATIENTS ON DUAL ANTIPLATELET THERAPY. J Thromb Haemost 2007; 5 Supplement 2: P-T-347
Abstract
Introduction: Inhibition of platelet aggregation via platelet P2Y12 receptor blockade by clopidogrel is effective in the prevention of major cardiovascular events. Light transmission aggregation (LTA) has been suggested as a tool to assess the residual platelet reactivity (RPR) in high risk coronary artery disease patients. In the literature different concentrations of agonist (ADP) and different evaluation of aggregation (maximal and late) curves have been reported in relation of the inhibitory effect of clopidogrel treatment.
Methods: Aim of our investigation was to study platelet LTA induced by two different concentrations of ADP (10 and 20 mM) and evaluated as maximal and late (10 min) aggregation in 211 acute coronary syndrome patients on dual antiplatelet therapy. Treated patients were considered to have a RPR when maximal and late aggregation was >70%.
Results: Mean maximal LTA was 54.919.2% and 59.718.9% by 10 and 20 mM ADP, respectively. Late LTA values were 49.423.0% and 55.122.8% by 10 and 20 mM ADP, respectively. Maximal values were significantly different from late aggregation values (p<0.01 for both ADP concentrations). The prevalence of patient with RPR was 24.2% (maximal) and 23.2% (late) by 10 mM ADP-LTA and 34.1% (maximal) and 31.3% (late) by 20 mM ADP-LTA. Considering maximal aggregation, a significant correlation between 10 and 20 mM ADP-LTA was observed (rho=0.90, p<0.001; concordant samples=87.2% with significant agreement k=0.70, p<0.001). Considering late aggregation, a significant correlation between 10 and 20 mM ADP-LTA was observed (rho=0.91, p<0.001; concordant samples=88.0% with a significant agreement k=0.70, p<0.001).
Conclusions: In conclusion, maximal and late LTA induced by 10 and 20 mM ADP seem to identify with a good agreement a similar percentage of patients with RPR.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
Session Details
| Date: |
01/08/2007
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| Time: |
00:00-00:00
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| Session name: |
XXIst ISTH Congress |
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| Location: |
Oxford, UK |
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