HYPERVISCOSITY AS A POSSIBLE DETERMINANT OF INFARCT SIZE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION

Abstract number: P-M-590

Cecchi¹ E., Alessandriello Liotta¹ A., Gori¹ A.M., Valente¹ S., Giglioli¹ C., Lazzeri¹ C., Sofi¹ F., Gensini¹ G.F., Abbate¹ R., Mannini¹ L.

¹Dipartimento di Area Critica Medico-Chirurgica, Centro Trombosi, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy

How-to-cite Cecchi E, Alessandriello Liotta A, Gori AM, Valente S, Giglioli C, Lazzeri C, Sofi F, Gensini GF, Abbate R, Mannini L. HYPERVISCOSITY AS A POSSIBLE DETERMINANT OF INFARCT SIZE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION. J Thromb Haemost 2007; 5 Supplement 2: P-M-590

Abstract

Introduction: Previous studies explored the association between hemorheological alterations and acute myocardial infarction, pointing out the role of hematological components on microvascular flow. Aim of this study was to evaluate the possible association between hyperviscosity and infarct size, estimated by both creatine kinase (CK) peak activity and cardiac Troponin I (cTnI) peak concentration in ST-segment Elevation Myocardial Infarction (STEMI) patients.

Methods: The study population included 215 consecutive STEMI patients undergoing percutaneous coronary intervention (PCI). Hemorheological studies were performed by assessing whole blood viscosity (WBV) at shear rates of 0.512 s-1 and 94.5 s-1 and plasma viscosity using the Rotational Viscosimeter LS 30 and erythrocyte deformability index (DI) by Myrenne filtrometer.

Results: According to CK peak activity and cTnI peak concentration tertiles an increase in WBV at both 0.512 s-1 and 94.5 s-1, white blood cell count, plasma viscosity, hematocrit, fibrinogen and a decrease in DI was observed. At multivariate analysis (adjusted for age, gender, traditional cardiovascular risk factors, renal dysfunction, total latency period > 6 hours, pre-PCI TIMI flow, multivessel disease and previous coronary artery disease) WBV at 94.5 s-1 and white blood cell count were independently and positively associated with infarct size.

Conclusions: These results demonstrate a significant and independent association between infarct size and hemorheological alterations in STEMI patients so suggesting that hyperviscosity, in a condition of low flow, might worsen myocardial perfusion leading to an increased infarct size. The measurement of WBV in STEMI patients could help to identify those who may benefit from new therapeutic strategies.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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