FIBRINOGEN THR312ALA BUT NOT FXIIIA VAL34LEU AND FXIIIB HIS95ARG POLYMORPHISMS ASSOCIATED WITH THAI DEEP VENOUS THROMBOSIS
Abstract number: P-M-566
Komanasin1 N., Angchaisuksiri2 P., Mongkolwongroj1 P., Puntumetakul1 M., Aryuchai2 K.
11Clinical Microscopy, Faculty of Associated Medical Science, Khon Kaen University, Khon Kaen 22Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
How-to-cite Komanasin N, Angchaisuksiri P, Mongkolwongroj P, Puntumetakul M, Aryuchai K. FIBRINOGEN THR312ALA BUT NOT FXIIIA VAL34LEU AND FXIIIB HIS95ARG POLYMORPHISMS ASSOCIATED WITH THAI DEEP VENOUS THROMBOSIS. J Thromb Haemost 2007; 5 Supplement 2: P-M-566
Introduction: Venous thromboembolism is a multifactorial disease and genetic factors are involved in the individual predisposition to develop the disease. Fibrinogen Thr312Ala, FXIIIA Val34Leu and FXIIIB His95Arg polymorphisms have been shown to be associated with venous thromboembolism in Caucasians but it has not been studied in Thai populations.
Methods: To address this issue, we investigated the prevalence of these three polymorphisms in 217 Thai healthy control subjects and 148 unselected Thai patients diagnosed with deep venous thrombosis (DVT) by venography or Doppler ultrasonography. The polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results: There were no significant differences in the FXIIIA Val34Leu and FXIIIB His95Arg genotype frequencies between DVT patients and healthy individuals and the prevalence of these two polymorphisms were very low in both groups (Val34Leu = 3.01% vs 2.38%, His95Arg = 4.65% vs 6.96%). However, the genotype distribution of the fibrinogen Thr312Ala polymorphism in patients with DVT (TT = 26.72%, TA = 34.35%, AA = 38.93%) differed significantly from healthy control subjects (TT = 42.65%, TA = 40.69%, AA = 16.67%, p < 0.001). Carriers of the Ala allele (TA + AA) have been determined to have an approximate 2 fold increased risk for DVT (odds ratio = 2.04, 95% CI = 1.27, 3.28).
Conclusions: This demonstrated that the fibrinogen Thr312Ala polymorphism is associated with deep venous thrombosis and may be a genetic risk factor for venous thromboembolism in Thai populations.
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Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
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