LIPID, INFLAMMATORY AND HAEMORHEOLOGICAL PROFILES ARE SIGNIFICANTLY AFFECTED BY FARMED FISH EATING: AN INTERVENTION STUDY
Abstract number: P-M-389
Sofi1 F., Gori1 A., Cesari1 F., Paniccia1 R., Mannini1 L., Casini2 A., Parisi3 G., Giorgi3 G., Poli3 B., Abbate1 R., Gensini4 G.
11Medical and Surgical Critical Care, Thrombosis Centre 22Clinical Pathophysiology, Unit of Clinical Nutrition, University of Florence, Azienda Ospedaliero-Universitaria Careggi 33Scienze Zootecniche, University of Florence 44Medical and Surgical Critical Care, Thrombosis Centre, Don Carlo Gnocchi Foundation, Florence, Italy
How-to-cite Sofi F, Gori A, Cesari F, Paniccia R, Mannini L, Casini A, Parisi G, Giorgi G, Poli B, Abbate R, Gensini G. LIPID, INFLAMMATORY AND HAEMORHEOLOGICAL PROFILES ARE SIGNIFICANTLY AFFECTED BY FARMED FISH EATING: AN INTERVENTION STUDY. J Thromb Haemost 2007; 5 Supplement 2: P-M-389
Abstract
Introduction: Fish intake has long been indicated as a protective dietary factor for cardiovascular disease. Over the last years, due to the reduction of wild fish stocks, farmed fish consumption has dramatically increased. Aim of this study was to evaluate the influence of short-term dietary intake of farmed fish on biomarkers related to the atherosclerotic process.
Methods: In 9 dyslipidemic subjects (5 F; 4 M with a mean age of 52.8 years) we evaluated lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides), inflammatory markers [highly-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and interleukin-8 (IL-8)], and haemorheological profile [whole blood viscosity (WBV), plasma viscosity, erythrocyte deformability index (DI)] before (T0) and after a dietary intervention with 900 g of Orbetello farmed sea bass (Dicentrarchus labrax) per week for 10 weeks (T1).
Results: A general linear model for repeated measurements after adjustment for age, gender, weight change and total fats' intake was conducted. Fish intake significantly decreased triglycerides (T1: 140 20.3 vs. T0: 184.3 29.2 mg/dL; p=0.04), whereas no significant changes for the other lipid variables have been observed. With regard to inflammatory pattern, dietary intervention significantly (p<0.05) decreased all the parameters investigated, namely hsCRP (T1: 2.2 0.06 vs. T0: 2.6 0.04 mg/L), IL-6 (T1: 1.9 0.7 vs. T0: 3.1 0.6 pg/mL) and IL-8 (T1: 12.6 0.09 vs. T0: 17.4 0.06 pg/mL). Furthermore, as regarding haemorheological parameters, a significant (p=0.04) improvement in DI was reported after 10 weeks of fish dietary intake (T1: 9.0 0.7 vs. 5.4 1.0% for T1 and T0, respectively).
Conclusions: Dietary short-term intake of farmed fish seems to impose favourable biochemical changes in dyslipidemic subjects, with regard to lower circulating levels of markers of atherosclerosis, such as lipid parameters, inflammatory markers, and haemorheological variables.
