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HAEMOSTATIC AND CYTOKINE CHANGES IN GESTATIONAL AND PREGESTATIONAL DIABETES MELLITUS

Abstract number: P-S-638

Abdel Gadir¹ A.M., Khashoggi² T.Y., Habib² F.M.

¹¹Physiology Dept and Blood Bank ²²Dept of Obstetrics and Gynecology, College of Medicine and King Khalid UNiversity Hospital, Riyadh, Saudi Arabia

How-to-cite Abdel Gadir AM, Khashoggi TY, Habib FM. HAEMOSTATIC AND CYTOKINE CHANGES IN GESTATIONAL AND PREGESTATIONAL DIABETES MELLITUS. J Thromb Haemost 2007; 5 Supplement 2: P-S-638

Abstract

Introduction: Limited data indicate the existence of a hypercoagulable state in gestational diabetes mellitus (GDM)and the possible involvement of pro-inflammatory cytokines in its pathogenesis

Methods: Three groups of women in the third trimester of pregnancy were studied: GDM (n = 180), pregnant women with pre-gestational diabetes- type 2 mellitus (n = 50), and controls: women with normal pregnancy (n = 100); GDM in their first day postnatal (n= 52).

Laboratory assays: Plasma fibrinogen (turbidometric assay), Antithrombin III (ATIII), Protein C, Protein S (total and Free), TFPI (total and free) interleukins-2, 6 and 8 (IL-2, 6, 8), using ELISA technique.

Results: During pregnancy the only significant alteration noted were higher levels of fibrinogen and total protein S in women with GDM and pre-gestational diabetes when compared to normal pregnancy. Free protein S was significantly higher in pregestational DM than in normal pregnancy.

In women with GDM in the postnatal period, fibrinogen displayed significant elevation as compared to those in the third trimester. Also, there was significant drop in the level of total and free protein S, Protein C, antithrombin III and free TFPI.

Interleukins: the only significant change noted was elevation in the levels of IL-6 and IL-8 postnatally.

Conclusions: Conclusion: The only indicator of a higher tendency towards hypercoagulability is the higher fibrinogen level in GDM, than in normal pregnancy. Women with controlled pregestational DM showed slightly more severe hypercoagulable tendency. The lack of change in the levels of pro-inflammatory cytokines levels do not support the existence of an inflammatory state in GDM nor in controlled pregestational DM. GDM is not associated with significant prothrombotic tendency.

(This research is supported by a grant # LGP–7–35 from King Abdul Aziz City for Science and Technology –KACST, Riyadh)

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

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