IN PERIODONTAL DISEASE THE INFLAMMATORY STATE IS ASSOCIATED WITH SUB-CLINICAL ATHEROSCLEROSIS

Abstract number: P-S-473

Gori¹ A.M., Cairo² F., Cesari¹ F., Bacci¹ M., Falciani¹ M., Pucci¹ N., Castellani¹ S., Pini Prato² G.P., Gensini¹ G.F., Abbate¹ R.

¹¹Medical and Surgical Critical Area ²²Periodontology, University of Florence, Florence, Italy

How-to-cite Gori AM, Cairo F, Cesari F, Bacci M, Falciani M, Pucci N, Castellani S, Pini Prato GP, Gensini GF, Abbate R. IN PERIODONTAL DISEASE THE INFLAMMATORY STATE IS ASSOCIATED WITH SUB-CLINICAL ATHEROSCLEROSIS. J Thromb Haemost 2007; 5 Supplement 2: P-S-473

Abstract

Introduction: A significant association between the extent and severity of periodontal disease(PD) and atherothrombotic diseases has been reported. PD is a chronic and multifactorial infectious disease of gingival tissues causing progressive bone loss around teeth. The aims of this study were to evaluate the role of the inflammatory markers (CRP, IL-1beta, IL-6, IL-8, TNF-alpha, IL-1ra, IL-4, MCP-1, MIP-1alpha and VEGF) in PD and to investigate the relationship between the inflammatory markers and intima-media thickness (IMT) in young patients with no systemic signs of atherosclerosis.

Methods: Carotid IMT was assessed by carotid ultrasonografy in 45 patients (36.43.6 yrs) affected by severe PD and 45 sex and age-matched controls(34.23.2 yrs). Cytochemokine levels were determined by Bio-Plex cytokine assay. CRP by a high-sensitivity assay.

Results: Carotid IMT values were higher (p<0.0001)in PD(0.820.02 mm)than in controls(0.730.07 mm). We detected higher CRP, as well as cytochemokine levels in PD than in controls [CRP:1.6(0.2-11.0) vs 0.7(0.1-4.0)mg/L; IL-6:84.0(5.7-663.2) vs 52.9(2.9-425.8) pg/ml; IL-8: 105.1(29.4-902.6) vs 59.7(16.0-233.4)pg/ml; IL-4:62.6(4.1-223.5) vs. 54.0(20.7-128.6) pg/l; IL-1ra: 1185.3(197.4-10278.0) vs 23.2(11.3-48.1)pg/ml; MCP-1:972.5(210.5-8365.0) vs 567.1(1883.5-190.6) pg/l; MIP-1alpha:63.8(30.0-1764.7) vs 48.7(26.3-138.3) pg/ml; VEGF:1087.9(8.4-6113.9) vs 434.4(0.8-2879.3) pg/m].In PD patients, at multiple linear regression analysis, after adjusting for age, sex and cardiovascular risk factors,IL-1ra and MIP-1alpha levels were significantly and positively related to IMT. An inverse and significant relationship between VEGF levels and PD was also observed. In controls, no significant association between PD and cytochemokines was found.

Conclusions: Severe periodontal disease in young patients is associated to sub-clinical atherosclerosis and has to be considered as an inflammation-mediated risk factor for cerebrovascular disease in young adults.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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