ABDOMINAL AORTIC ANEURYSM AND CAROTID ARTERY DISEASE: GENE EXPRESSION PROFILING OF TWO ATHEROSCLEROTIC DISEASES

Abstract number: P-S-455

Giusti¹ B., Rossi¹ L., Lapini¹ I., Lavitrano² M.L., Biasi² G.M., Pulli³ R., Pratesi³ G., Pratesi³ C., Abbate¹ R., Gensini⁴ G.F.

¹¹Department of Medical and Surgical Critical Care, University of Florence, Florence ²²Department of Surgical Sciences and Intensive Care, University of Milano-Bicocca, Milan ³³Department of Vascular Surgery, University of Florence ⁴⁴S.Maria agli Ulivi Center, Don C. Gnocchi Foundation Onlus IRCCS, Florence, Italy

How-to-cite Giusti B, Rossi L, Lapini I, Lavitrano ML, Biasi GM, Pulli R, Pratesi G, Pratesi C, Abbate R, Gensini GF. ABDOMINAL AORTIC ANEURYSM AND CAROTID ARTERY DISEASE: GENE EXPRESSION PROFILING OF TWO ATHEROSCLEROTIC DISEASES. J Thromb Haemost 2007; 5 Supplement 2: P-S-455

Abstract

Introduction: Abdominal aortic aneurysm (AAA) and carotid artery disease (CAS) are two manifestations of atherosclerosis, but the molecular bases responsible for the different localization are not completely understood. Aims of the study were to identify, at systemic level by microarray technology, altered genes involved in pathophysiology of atherosclerosis and expression profiles that are highly correlated with these two atherosclerotic phenotypes.

Methods: At this purpose we analyzed expression profiles in total RNA from whole blood of 10 patients affected by AAA, 10 patients with CAS and 20 controls comparable for age and sex. We determined the expression of 14,000 genes by two colours microarray technology.

Results: 93 genes showed altered expression levels between AAA patients and controls: 77 up-regulated and 16 down-regulated genes. As concerns CAS patients, 62 genes showed altered expression: 40 up-regulated and 22 down-regulated genes. 26 genes were similarly altered in both AAA and CAS patients. Gene ontology analysis showed an alteration of the following biological processes: oxygen transport, protein synthesis, cytoskeleton organization and lipidic metabolism.

Conclusions: Our results may contribute to a better understanding of the genes and biological processes involved in the pathophysiology of atherosclerosis and to the identification of a disease profile able to characterize affected subjects

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
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