THE EFFECT OF EXERCISE ON FIBRINOLYTIC AND COAGULATION SYSTEMS IN HEALTHY VOLUNTEERS
Abstract number: P-S-362
Kahraman1 S., Demirkan1 F., Bediz2 C., Alacacioglu1 I., Aksu2 I., Piskin1 O., Turgut1 N., Ozcan1 M., Ozsan1 H., Undar1 B.
11Hematology 22Sport-Physiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
How-to-cite Kahraman S, Demirkan F, Bediz C, Alacacioglu I, Aksu I, Piskin O, Turgut N, Ozcan M, Ozsan H, Undar B. THE EFFECT OF EXERCISE ON FIBRINOLYTIC AND COAGULATION SYSTEMS IN HEALTHY VOLUNTEERS. J Thromb Haemost 2007; 5 Supplement 2: P-S-362
Introduction: In this study, we aimed to evaluate changes in coagulation and fibrinolytic occurring after submaximal exercise.
Methods: 12 healthy, non-smoker volunteers who did not have comorbid disease, take any medication for the last six months and make regular exercise, were included in the study. All subjects were tested on the cycle ergometer to maximal level of exertion. Cardiac and respiratory parameters were monitored. Peripheral blood samples were taken before (baseline) and within 0, 15 and 60 minutes after the test. Prothrombin time (PT), partial activated-thromboplastin time (aPTT), d-dimer, fibrinogen, plasminogen-activator inhibitor 1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI) levels were measured. Mann-Whitney U test was used in statistical analysis to compare differencies between groups. Linear regression analysis with Pearson coefficients was employed to assess correlations between studied parameters.
Results: PT, D-dimer levels produced significant increase at 0. and 60. minutes after exercise when they were compared to baseline levels [In both: p=0.002, p=0.002 (0, 60.min)]. Whereas, aPTT levels increased non-significantly at 0. min relative to baseline and shortened at 60.min compared to baseline and 0. min. significantly (baseline -60.min p = 0,019/0-60. min p= 0,007). Fibrinogen levels did not show any significant changes compared to baseline levels. When we compared PAI-I and TAFI levels in 0. and 60. minutes after training, there was a marked decrease (p=0.033) regarding PAI-I together with a decrease in TAFI levels which was not statistically significant.
Conclusions: It can be concluded that submaximal aerobic training may be the most suitable form of exercise for healthy persons due to improvement in fibrinolytic activity. Future studies including in addition to more healthy volunteers are required to evaluate the precise effect of exercise on fibrinolytic and coagulation systems.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number
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