PROTEIN Z PLASMA LEVELS IN DIFFERENT LOCALIZATIONS OF ATHEROSCLEROTIC DISEASE

Abstract number: P-S-104

Sofi¹ F., Cesari¹ F., Capalbo¹ A., Alessandrello Liotta¹ A., Pratesi² G., Troisi² N., Pratesi² C., Abbate¹ R., Gensini¹ G., Fedi¹ S.

¹¹Medical and Surgical Critical Care, Thrombosis Centre ²²Medical and Surgical Critical Care, Unit of Vascular Surgery, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

How-to-cite Sofi F, Cesari F, Capalbo A, Alessandrello Liotta A, Pratesi G, Troisi N, Pratesi C, Abbate R, Gensini G, Fedi S. PROTEIN Z PLASMA LEVELS IN DIFFERENT LOCALIZATIONS OF ATHEROSCLEROTIC DISEASE. J Thromb Haemost 2007; 5 Supplement 2: P-S-104

Abstract

Introduction: Protein Z is vitamin K-dependent plasma glycoprotein that acts as a cofactor for the inactivation of activated factor X. We previously reported that low protein Z plasma levels are associated with acute coronary syndromes (ACS) and that this association persists also in a chronic phase of the coronary disease. However, no data are available on the role of protein Z for other localizations of atherosclerosis

Methods: We compared 360 healthy subjects [median age:74 years (37-87);306 M, 54 F] with 360 patients [median age: 75 years (36-93); 306 M,54 F] with a clinical manifestation of atherosclerosis [120 ACS; 120 with the evidence of carotid artery stenosis (CAS) and 120 with peripheral occlusive vascular disease (POAD)]. Protein Z plasma levels were measured using an enzyme linked immunoadsorbent assay (Roche Diagnostics).

Results: Circulating levels of protein Z were found to be significantly (p<0.005) lower (1588.5874.8 ng/mL) in atherosclerotic patients with respect to healthy controls (1742.5626.2 ng/mL). In particular, by dividing our study population into the different localizations of the disease, protein Z levels were found to be significantly lower in ACS and POAD patients (1379616 ng/mL; 1561.1940.6 ng/mL, respectively) with respect to controls, but not in CAS patients (1825.3970.9 ng/mL). We performed a logistic regression analysis by dividing the study population into tertiles of protein Z distribution among the healthy control group and after a multivariate analysis adjusted for potential confounders, lowest tertile (<1.508 ng/mL) of protein Z resulted to be significantly associated with an increased risk of atherosclerosis (OR: 1.62 95%CI 1.08-2.42; p=0.02). However, when subgrouped by different localizations of the atherosclerotic disease the lowest tertile of protein Z showed to be an independent risk factor for ACS, but not for CAS and POAD.

Conclusions: Our data show a possible district-related role of protein Z in the pathogenesis of the atherothrombotic process.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	01/08/2007
Time:	00:00-00:00
Session name:	XXIst ISTH Congress
Subject:
Location:	Oxford, UK
Presentation type:
Back to top

| ISTH 2009