Adiponectin Correlation with Plasma Lipoprotein Subclasses Determined by NMR and with the Risk of Venous Thrombosis

Abstract number: P2227

Fernández JA, Deguchi H, Pecheniuk NM, Elias DJ, Griffin JH

Adiponectin is a homotrimeric hormone derived from adipose tissue and its deficiency is linked to coronary heart disease and dyslipidemia. The crystal structure of adiponectin showed its similarity to TNF-alpha that might be related to its anti-inflammatory properties. The physiologic roles of adiponectin are poorly understood. Recent reports suggest venous thrombosis is linked to atherosclerotic plaque burden and dyslipoproteinemia. To investigate the relationship of adiponectin levels with 10 different lipoprotein subclasses that were quantitated in plasma by NMR, as well as the association of adiponectin levels with venous thrombosis, we measured adiponectin levels (by ELISA) for subjects in the Scripps VTE Registry (n= 189), a well characterized age and sex matched venous thrombosis and control population. We found no differences (P= 0.5) in adiponectin between VTE patients (7.7 ± 0.4 µg/ml) and controls (7.3 ± 0.3 µg/ml). Significant Spearman positive correlations for adiponectin with HDL cholesterol (r= 0.404), Apo AI (r= 0.225) and negative correlations with BMI (r=-0.327), triglycerides (r=-0.447), and apo B (r=-0.243) were found suggesting an association of adiponectin with a healthy lipid profile in agreement with literature. The NMR lipoprotein subclasses of HDL, LDL and VLDL were further divided by particle size in large, medium, and small particles. The results revealed that adiponectin significantly correlates positively with large HDL and LDL and negatively with small HDL and LDL. The correlation of adiponectin with each VLDL subclass was negative consistent with the known negative correlation with triglycerides. In summary, these results imply that the relationship of adiponectin with lipoproteins is more complex than previously estimated and is more related to large lipoprotein particle size, independent of the apolipoprotein content. In contrast to coronary heart disease, low adiponectin levels appear not to be related to venous thrombosis.