Platelet Aggregation and ATP Release Values in Children and Adults

Abstract number: P2050

Bonduel M, Frontroth JP, Hepner M, Pieroni G, Sciuccati G, Feliú A

The hemostatic system is constantly changing throughout life. Many components do not reach adults levels until the late teen years. Different aggregation patterns compared to adults were described in cord blood platelets. Age-based reference ranges can allow for an accurate interpretation of pediatric platelet disorders and, for a more adequate monitoring of antiplatelet therapy. We evaluated platelet aggregation responses to several agonists in 66 healthy children and 115 adults. Results were grouped by age and expressed as median with intervals including 95% of the population. Different agonists were assayed and the results are expressed in percentage of maximum aggregation. ATP release was measured using high dose of collagen as stimuli.

We conclude no differences in platelet aggregation and ATP release values between children older than 1 year and adults have been found in this preliminary study.