Alteration of Protein Z in Cardio-Cerebra Thrombotic Diseases and Its Significance

Abstract number: P1893

Pan¹ X-Y, Bao² C-X, Zhou¹ W-X, Huan¹ X-M, Guo¹ Y

¹¹Department of Hematology, The First Affiliated Hospital of Guangdong Pharmaceutical College, Guangzhou, China ¹¹Department of Hematology, The First Affiliated Hospital of Guangdong Pharmaceutical College, Guangzhou, China ²²Institute of hematology, CAMS and PUMC, Tianjin, China

Objective:  Studies on the alteration of protein Z (PZ) in patients with cardio-cerebral thrombotic diseases, its clinical significance and relations with FX.

Methods:  Both PZ and FX : Ag levels were measured by ELISA, and Plasma FX : C by first stage method. In 170 patients with acute ischemic stroke (AIS), 40 patients with acute myocardial infarction (AMI) and 60 healthy adults as control, PZ, FX : C and FX : Ag were studied and compared between incipience and recurrence, different age and genders in the patient groups.

Results:  In AIS and AMI groups, PZ levels decreased significantly to (940.02 ± 229.82) µg/L and (1071.44 ± 180.52) µg/L, respectively [the control group was (2257.97 ± 479.76) µg/L, P < 0.001]. But FX : C and FX : Ag level raised to (136.73 ± 34.93)% and (135.54 ± 54.39)% in AIS group; and to (139.53 ± 29.18)%, (129.75 ± 21.91)% in AMI group, respectively, while in the control group they were (94.33 ± 22.00)%, (77.22 ± 13.19)% (P < 0.001). In the comparative studies between the AIS group, AMI group and the control group, PZ level was clearly found to negatively relate to the level of FX : C and FX : Ag (P < 0.001). Meanwhile, PZ level, FX : C and FX : Ag in recur-AIS group and recur-AMI group exhibited significant differences (P < 0.05) from those in the primary AIS and AMI groups, suggesting that the decrease of PZ levels reflected the pathological process of the disease. In addition, PZ level gradually decreased with the raise of age (P < 0.05), while no FX : C and FX : Ag were found such relations with age (P > 0.05). No correlation was found in sex with PZ level, FX : C and FX : Ag (P > 0.05).

Conclusion:  PZ level was significantly decreased in AIS and AMI patients and was negatively related to FX : C and FX : Ag level. The mechanism leading to FX increase may partially related with the decreased of PZ. PZ level was different in the primary and recurrent diseases and was gradually decreased with the raise of age. Lack of PZ might be an etiological factor of cardio-cerebral thrombotic disease.