Soluble P-Selectin Levels in Diabetes Mellitus Patients with Coronary Artery Disease

Abstract number: P1868

Aref S, Sakrana M, Abdel Hafez A, Hamdy M

Soluble P-selectin levels were measured by ELISA in the peripheral blood of 55 diabetic patients with coronary artery disease [21 acute myocardial infarction (AMI), 20 with unstable angina (UA), 14 with stable angina (SU)], 20 patients with diabetes mellitus without coronary artery disease (DM without), and 10 healthy controls. Soluble P-selectin levels were significantly higher in patients with AMI (M ± SD; 239.3 ± 13.0 ng/ml), than those with UA (141.5 ± 15.2 ng/ml), SU (92.1 ± 7.67 ng/ml), DM without (89.8 ± 7.1 ng/ml), and healthy control (69.1 ± 4.5 ng/ml) (P < 0.001). In patients with US, sP-selectin was found to be significantly elevated as compared to the SU, DM without and control group. sP-selectin was not significantly different in DM without as compared to controls. The sP-selectin levels was correlated to the duration of diabetes mellitus(R= 0.33, P= 0.03). Moreover, sP-selectin level was significantly higher in AMI patients with recurrent anginal attack as compared to that in those with single attack (P 0.041). Multivariate analysis revealed that sP-selectin levels at presentation had high adverse influence on coronary artery insult compared to LDL cholesterol level, degree of hypertension. In Conclusion: Measurement of soluble p – selectin may be helpful marker of impending coronary artery insult in diabetic patients