Alterations of the Tissue-Factor Induced Pathway of Coagulation during Acute Deep Vein Thrombosis (DVT): Significant Increase in Tissue-Factor Pathway Inhibitor (TFPI)
Abstract number: P1345
SidelmannMünsterMünster1,223 JJAMBH, Bertelsen3 V, Mourits-Andersen4 T, Bladbjerg1,2 EM
1,2 1,2232Department of Clinical Biochemistry, Ribe County Hospital, Esbjerg, Denmark3Department of Radiology, Ribe County Hospital, Esbjerg, Denmark 33Department of Radiology, Ribe County Hospital, Esbjerg, Denmark 44Department of Haematology, Ribe County Hospital, Esbjerg, Denmark
Background: Case-control studies have established reduced plasma concentration of TFPI as a DVT-risk factor, suggesting TFPI to be part of the pathogenesis of venous thromboembolism. However, the regulation of the tissue-factor induced pathway of coagulation during the acute phase of DVT has not been addressed so far.
Materials and methods: We determined factor VII clotting activity (FVIIc), factor VII antigen (FVII:Ag), total TFPI and the TFPI -287T/C polymorphism in 21° Consecutive patients, not receiving hormone or anticoagulant therapy, upon admission to hospital with a tentative diagnosis of DVT.
Results: DVT was identified (phlebography and ultrasound) in 74 patients. The TFPI -287T/C genotypes were equally frequent in patients with and without DVT. The concentration of TFPI was significantly and consistently higher in the patients with DVT (median 89.5 ng/ml) than in the patients without DVT (median 69.0 ng/ml), P < 0.001, irrespective of the -287T/C genotypes. The concentration of FVIIc and FVII:Ag showed no significant differences between the two groups of patients.
Discussion: The PRIME-study and the LETS-study show that reduced concentration of TFPI is a risk factor for development of myocardial infarction and DVT. These studies, however, were conducted in the non-acute phase of thrombotic disease. In contrast, it has been demonstrated that patients suffering from acute myocardial infarction express significantly increased concentrations of TFPI. Presently, we find a resembling increase in the concentration of TFPI among patients suffering from acute DVT. These findings suggest that TFPI-increase is a feature of acute thrombosis.
Conclusion: The concentration of TFPI is significantly increased in patients suffering from acute DVT regardless of the genotype of the TFPI -287T/C polymorphism.
To cite this abstract use the following format:
Journal of Thrombosis and Haemostasis 2005; Volume 3, Supplement 1: abstract number
|Session name:||XXIst ISTH Congress|
|Subject:||Poster Session Wednesday|
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