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The Risk of Proximal DVT and Pulmonary Embolism (PE) in Patients with Objectively Verified Arterial Thrombosis. A Population-Based Autopsy Study
Abstract number: P1066
Eliasson1 Å, Bergqvist1 D, Björck1 M, Acosta1 S, Sternby2 NH, Ögren1 M
11Uppsala University Hospital, Uppsala, Sweden 11Uppsala University Hospital, Uppsala, Sweden 22Lund University, Malmö University Hospital, Malmö, Sweden
Background: Whether there is an association between risk for developing arterial and venous thrombosis remains unclear. Studies evaluating atherothrombotic diseases often have low precision in VTE diagnosis. In this analysis we investigated the relationship to objectively verified VTE in patients with thrombosis in major artery segments. Methods: In a cohort of 23 796 autopsies representing 84% of all in-hospital deaths 1970–82 in the population of Malmö, Sweden, the prevalence of proximal DVT (pDVT) and PE was related to presence of arterial thrombosis and expressed in terms of OR* (95% CI). Results: Patients with arterial thrombosis had 23% increased odds for VTE (95% CI: 13–35%) (P < 0.001). The association between pDVT and PE, and subgroups of arterial thrombosis remained, except for coronary thrombosis, where a lower risk was found. | Arterial thrombosis | Mean age | % men | OR* for pDVT | OR* for PE |
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| Cervico-cranial artery | 77 years | 43% | 1.8 (1.4–2.2) | 1.4 (1.2–1.7) | | Coronary artery | 74 years | 60% | 0.7 (0.5–0.8) | 0.8 (0.7–0.9) | | Aortic artery | 82 years | 44% | 2.9 (2.5–3.4) | 1.0 (0.8–1.1) | | Visceral artery | 79 years | 42% | 2.1 (1.7–2.6) | 1.3 (1.1–1.6) | | Iliacofemoral artery | 80 years | 47% | 2.4 (2.1–2.8) | 1.1 (0.9–1.3) |
Conclusions: A positive correlation between venous and arterial thromboembolic disease was confirmed except for cases with coronary artery thrombosis, where early mortality in MI may be a confounding factor in this younger, predominantly male cohort.
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