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A Comparison of the Canadian Hemophilia Outcomes – Kids Life Assessment Tool (CHO-KLAT) and the HaemoQoL
Abstract number: P0808
McCusker1,2 PJ, Wakefield5 CD, Bradley5 CS, Barnard3 D, Blanchette4,5 VS, Young4,5 NL
4,5 1,21University of Manitoba Winnipeg, Canada 33Dalhousie University, Halifax, Canada 55Hospital for Sick Children, Toronto, Canada
This report compares the characteristics of the CHO-KLAT and the HaemoQoL. These two quality of life measures were developed in response to the need for a child-report measure for boys with hemophilia. Both measures have favorable measurement properties. The measures differ in several aspects, primarily in the philosophy of their development. Information from the developmental stages and data from the Canadian study employing both measures were analyzed. See below: | | CHO-KLAT | Haemo Qol |
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| Guiding Principles | Driven by the perspectives of kids Incorporates input from parents and health professionals. Item reduction: statistically directed, guided by children's preferences. | Derived from expert consensus. Item reduction: statistically driven, guided by academics and health professionals | | Countries | One (Canada) | 6 countries (European) | | Cultures | Multi-cultural; ethnically diverse | Multi-cultural | | Item Phrasing | Child friendly wording Based on children's suggested wordings | Some items are cognitively complex Checked for developmental appropriateness | | Versions & Domain Structure | Single version Ages: 4 to 18 years; 35 items Summary score (×1) 0–100, 100 = best no domain structure | Long and short versions × 3 Ages: 4–7, 8–12, 13–16; 16 to 36 items Summary scores (×2) 0 = best 8–9 domains | | Languages | English | Multi-Lingual | | Measurement Properties | Concordance between kids and parents (0.75) Consistency over time (0.74 kids 0.83 parents) | Concordance between kids and parents (0.55) |
These measures both show promise for use in clinical trials. Developed from different perspectives, the summary scores are highly correlated (0.74 for child-report and 0.82 for parent-report). The HaemoQoL may be favored when the priority is multiple language versions. Because of its high child-parent concordance, child-centric wording and philosophy of development, the CHO-KLAT is recommended when the priority is to obtain child self-report. Investigations using both tools simultaneously should continue.
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