| N |
| Nadal M. V. |
- |
Effects of factor VIII (fVIII) levels and activated partial thromboplastin time (aPTT) in activated protein C resistance (APC-R) ratio using two different methods |
| |
- |
Behaviour of the protein C (PC)/protein S (PS) ratio in patients with thrombosis |
| |
- |
Prevalence of haemostatic and fibrinolytic abnormalities in women with unexplained embryofetal losses and vascular obstetric complications |
| Nadal T. |
- |
Two sensitive chromogenic assays of fondaparinux sodium (Arixtra®), a new synthetic and selective inhibitor of factor Xa, in plasma |
| Nadal M. V. |
- |
Virtual decrease of von Willebrand Factor-cleaving protease (ADAMTS13) after infusion of desmopressin (DDAVP) |
| |
- |
Fibrinolytic activity and response to venous occlusion in activated protein C resistance phenotype |
| Nadal Seillant M. |
- |
Platelet von Willebrand factor antigen (VWF:Ag-i) in patients with mucocutaneous bleeding tendency and normal von Willebrand factor (VWF) plasma levels |
| NAD'Ali F. |
- |
Effect of ergometric exercise on factor VIII coagulant activity in patients with mild and moderate hemophilia A |
| Nadar S. |
- |
Platelet activation and morphologic changes in hypertension |
| |
- |
Platelet P-selectin and target organ damage in hypertension |
| Nadar S. |
- |
Increased platelet adhesion in metastatic cancer |
| Nadifi S. |
- |
Prevalence of methylenetetrahydrofolatereductase (MTHFR) gene polymorphism (C677T) in the Moroccan population |
| Nadir Y. |
- |
Hemostatic balance on leukemic cells surface role of TF and uPAR |
| Nadvaev A. |
- |
Crystal structure at 1.7 A of aggretin, a heterodimeric C-type lectin snake venom protein |
| Naemura A. |
- |
Effect of a nitric oxide donor on platelet reactivity and spontaneous thrombolysis in patients with chronic renal failure |
| |
- |
Effect of ADP P2Y12 receptor inhibition on thrombosis and bleeding measured using guinea pigs |
| Nafissi N. |
- |
Rapid screening of factor IX mutations by SSCP and sequencing in 50 Iranian families |
| Nafissi Z. |
- |
Psychosocial aspects of inherited bleeding disorders among Iranian patients |
| Nafissi N. |
- |
Rapid analysis of the HindIII/intron 19 polymorphism within the human factor VIII gene by ARMS/PCR method |
| Nagahama Y. |
- |
Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with DIC |
| Nagai N. |
- |
Increased expression of endogenous tissue-type plasminogen activator and matrix metalloproteinase 9 contribute to heparin-produced cerebral hemorrhage after focal cerebral ischemia in mice |
| Nagai T. |
- |
A novel ELISA method for soluble fibrinogen and fibronectin complexes (FGFN) in normal adult's and DIS patient's plasma |
| Nagaizumi K. |
- |
Roles of the individual g-carboxyglutamic acid residues of factor VII |
| Nagakawa P. A. |
- |
A proposed mechanism for reduced bleeding of direct thrombin inhibitors as compared to heparin as measured by thromboelastography |
| Naganuma Y. |
- |
Platelet endothelial cell adhesion molecule-1 (PECAM-1) of platelets is cleaved under high shear stress |
| Nagao T. |
- |
Correlation between anti-coagulant therapeutic range and Prothrombin Fragment 1 + 2 in Japanese patients with Cardioembolic Stroke |
| Nagasawa T. |
- |
Effects of CS-747, a novel P2Y12 receptor antagonist, on cerebral and peripheral arterial occlusive diseases in rats |
| Nagashima M. |
- |
Activated thrombin–activatable fibrinolysis inhibitor (TAFIa) prevents spontaneous fibrinolysis of batroxobin-induced fibrin deposition in rat lungs |
| Nagaswami C. |
- |
Anti-fibrinogen IgG from a thrombophilic A alpha R16C (Fibrinogen Northspring) proband accelerates release of clot bound thrombin by enhancing fibrinolysis: a novel thrombogenic mechanism |
| |
- |
A monoclonal antibody to the fibrinogen g chain alters clot structure and properties by producing thinner fibrin fibers arranged in bundles |
| Nagata K. |
- |
Ligand for peroxisome proliferator-activated receptor-a (PPARa) Down-regulates tumor necrosis factor - a-induced pro-coagulant activation of tissue factor through inhibition of ap-1-dependent gene transcription in human endothelial cells |
| Nagle A. J. |
- |
Probabilistic modeling of population-based epidemiology and treatment modalities to determine unconstrained factor VIII demand |
| Nagler A. |
- |
Prevalence of circulating procoagulant microparticles in allogeneic stem cell transplantation (alloSCT) for hemato-oncological malignancies |
| Naglieri E. |
- |
A double-blind placebo-controlled randomized study on the efficacy and safety of enoxaparin for the prevention of upper limb deep vein thrombosis in cancer patients with central vein catheter |
| Nagy Z. |
- |
Thrombolytic therapy in acute ischemic stroke: same method, same team, different drug |
| Naik M. U. |
- |
Dissociation of the JAM-1/avb3 complex followed by signaling through JAM-1 is key to the angiogenic response induced by bFGF: an explanation of the avb3 paradox |
| Naik U. P. |
- |
Dissociation of the JAM-1/avb3 complex followed by signaling through JAM-1 is key to the angiogenic response induced by bFGF: an explanation of the avb3 paradox |
| Naik M. U. |
- |
Calcium- and integrin-binding (CIB) protein is required for platelet spreading on immobilized fibrinogen: functional association of CIB with GPIIb/IIIa |
| Naik U. P. |
- |
Calcium- and integrin-binding (CIB) protein is required for platelet spreading on immobilized fibrinogen: functional association of CIB with GPIIb/IIIa |
| Naimushin Y. A. |
- |
Ligand binding to GP IIbIIIa and stimulation of platelet release reactions |
| Nair S. |
- |
Glanzmanns thrombasthenia in Indians how different it is from other ethnic groups |
| Naito S. |
- |
Synthetic inhibitors of coagulation factor Xa suppress thrombin generation without affection on initial thrombin forming time |
| Naka H. |
- |
Hemophilia A gene therapy using the third-generation lentiviral vector Mouse model |
| Nakabayashi T. |
- |
Synthetic inhibitors of coagulation factor Xa suppress thrombin generation without affection on initial thrombin forming time |
| Nakagaki T. |
- |
VWF/FVIII concentrate enhances platelet adhesion onto a surface of immobilized collagen under flow conditions |
| |
- |
Mutations of ADAMTS13 gene in four Japanese families with UpshawSchulman syndrome |
| Nakagawa K. |
- |
Involvement of VEGF-C/flt-4 system in therapeutic angiogenesis of FGF-2 gene transfer in murine ischemic hind limb |
| Nakagawa P. |
- |
Paradoxical effect of Factor XIII replacement on clot initiation |
| |
- |
The laboratory evaluation of aspirin-resistance in normal, healthy subjects |
| Nakahara M. |
- |
Degradation pathway of the naturally occurring mutants of protein C and plasmin inhibitor by the proteasome |
| Nakamura T. N. |
- |
The possible role of calpain in cancer mediated vascular endothelial cell (vEC) retraction |
| Nakamura S. |
- |
New functions of neutrophils in inflammation: tissue factor-triggered clotting induction and elastase-mediated fibrinolysis |
| Nakamura S. |
- |
Nonmethylated status of promoter CpG islands in human tissue factor gene |
| |
- |
Androgen receptor-mediated suppression of tissue factor gene expression in male reproductive organs |
| Nakanishi Y. |
- |
Effects of CS-747, a novel P2Y12 receptor antagonist, on cerebral and peripheral arterial occlusive diseases in rats |
| Nakano S. |
- |
Effect of KFA-1982, a new orally active factor Xa inhibitor, in a rabbit venous thrombosis model |
| Nakano T. |
- |
Remnant-like lipoprotein particles potentiate platelet activation under high shear stress assessed by the collagen column, filled with collagen-coated small beads |
| Nakano M. |
- |
C-reactive protein induces the expression of tissue factor and interleukin-8 in the lung |
| Nakao S. |
- |
Is an antithrombin substance (aFIIa) more hemorrhagic compared with an anti-factor Xa (aFXa) aent?: Differential inhibitory effects of these two agents against platelet activation |
| |
- |
Three novel point mutations that cause severe factor XI deficiency in two unrelated Japanese families |
| |
- |
Rituximab reduces anti-phospholipid antibody (APA) titers and improves hypercoagulability in patients with anti-phospholipid syndrome (APS) |
| Nakashima Y. |
- |
Involvement of VEGF-C/flt-4 system in therapeutic angiogenesis of FGF-2 gene transfer in murine ischemic hind limb |
| |
- |
Immunohistochemical expression of interleukin-10 (IL-10) in atherosclerotic intimas of human coronary arteries |
| Nakatani T. |
- |
Successful argatroban-anticoagulant management for left ventricular assist system implantation in two patients with heparin-induced thrombocytopenia type II |
| Nakatomi Y. |
- |
VWF/FVIII concentrate enhances platelet adhesion onto a surface of immobilized collagen under flow conditions |
| Nakazawa F. |
- |
An intracellular cofactor of Factor VII activating protease (FSAP) functions as an initiator of blood coagulation |
| Nakazawa F. |
- |
Degradation pathway of the naturally occurring mutants of protein C and plasmin inhibitor by the proteasome |
| Nakov R. |
- |
Phlebographic response and clinical outcome in the treatment of acute deep vein thrombosis |
| Nalbone G. |
- |
Transmembrane TNFa and wild-type TNFa differently modulate atherosclerotic process in mice |
| Namba M. |
- |
Platelet-derived microparticle preparations for enzyme-linked immunoassay, and the high PDMP level detected in unstable angina patients |
| Nanda N. |
- |
CD84 signaling is a novel platelet stimulatory mechanism that occurs during platelet aggregation |
| Naohiro K. |
- |
Hypercoagulation and elevated blood pressure induced by phosphatidylserine/phosphatidylcholine microvesicles in pregnant mice can be suppressed by heparin and annexin V |
| Naoki U. |
- |
ADP regulates the expressions of tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1(PAI-1) in rat aortic endothelial cells |
| Napoleone E. |
- |
Tissue factor expression by human endothilial cells is down-regulated by antagonists of the renin-angiotensin system |
| Napoleone E. |
- |
Polymorphisms of the interleukin 1-b gene, inflammatory and hemostatic response and the risk of premature myocardial infarction |
| |
- |
Resveratol and quercetin inhibit tissue factor expression in vascular cells by preventing IkappaBalpha degradation and c-Rel/p65 activation |
| Narasaki R. |
- |
Affinity-trap protease reactor for single-step conversion/purification of angiostatin from human plasma |
| Nardi M. T. |
- |
Management of hospitalized patients with suspected deep vein thrombosis |
| Narhi L. |
- |
Kozak sequence polymorphism of the platelet glycoprotein Ibalpha gene and Thr789Ala polymorphism of the von Willebrand factor gene in fatal CAD |
| |
- |
Relation of prothrombotic platelet polymorphisms to the first manifestation of Coronary Artery Disease in middle-aged males |
| Nash G. B. |
- |
Conditioning of endothelial cells by different levels of fluid shear stress modulates their ability to induce each stage of neutrophil adhesion and migration in response to TNF-a but not IL1-b |
| Nash G. |
- |
Blood transfusion is associated with an enhanced pro angiogenic state |
| Nash G. B. |
- |
Neutrophils recruited by TNF-a stimulated endothelial cells down regulate subsequent endothelial VCAM-1 expression and inhibit the adhesion of a secondary bolus of flowing peripheral blood lymphocytes |
| Nash M. |
- |
A proposed ISTH revised classification for the anti-phospholipid syndrome |
| Nash G. B. |
- |
Neutrophils rapidly recruited by TNF-a stimulated endothelial cells can exit the sub endothelial environment by reverse transmigration over hours: is this a novel route for neutrophil clearance from inflamed tissue? |
| |
- |
Endothelial cells cocultured with monocytes are activated to support the adhesion of flowing leukocytes by a combination of TNF-a IFN-g and TGF-b1, a process that is progressively ablated as monocytes differentiate into macrophages |
| Nash M. |
- |
Paradoxical association between the 316 Trp to Ser beta 2-glycoprotein I (beta2GPI) polymorphism and antibeta2GPI antibodies |
| Nash G. |
- |
Sequential adhesion of platelets and then leukocytes from blood flowing over collagen in simple laminar and disturbed flow |
| Nasir F. |
- |
Blood transfusion is associated with an enhanced pro angiogenic state |
| Nasissi N. |
- |
Reporting presence of 9 novel mutations in hemophilia B patients in Iran |
| Nasl C. |
- |
Abciximab reduces monocyte tissue factor after carotid angioplasty and stenting: role of monocyte platelet cross talk in cerebral microembolization |
| |
- |
Abciximab reduces monocyte tissue factor after carotid angioplasty and stenting: role of monocyte platelet cross talk in cerebral microembolization |
| Nassonov E. |
- |
Factor V Leiden, prothrombin G20210A, and MTHFR C677T gene mutations in patients with primary anti-phospholipid syndrome and cerebrovascular disorder |
| Natella F. |
- |
Antioxidant effect of wine in human: role of polyphenols |
| Nath E. |
- |
Anticoagulant prophylaxis usage in cancer patients undergoing treatment |
| Naud S. |
- |
Quality of life and risk perception in a large family with heritable protein C deficiency (IPCI: International Protein C Investigation) |
| Naud S. J. |
- |
Lower degree of protein C activation in protein C deficient individuals of a large kindred with type I PC deficiency, as measured by the level of APC-PCI complex |
| Naud S. |
- |
Asymptomatic venous thrombosis is a frequent event in protein C deficiency: a systematic ultrasound assessment of 208 family members with the 3363-C insertion mutation (IPCI: International Protein C Investigation) |
| Naumnik B. |
- |
Induction of serum hepatocyte growth factor/activin/follistatin system during enoxaparin-anti-coagulated hemodialysis |
| Naumnik B. |
- |
Relation between circulating endothelial markers and anti-coagulation with different heparins in hemodialysis patients: a prospective study |
| Navaglia F. |
- |
Factor VII deficiency associated with severe hemophilia A |
| Navale L. |
- |
Clinical evaluation of an advanced category recombinant FVIII, anti-hemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM) in pediatric previously treated patients (PTPs) |
| Navaneetham D. |
- |
Factor XI-activation by thrombin on activated platelets requires both anion binding exosites I and II |
| Navarro S. |
- |
The 4678G/C polymorphism in the endothelial protein C receptor (EPCR) gene is associated with levels of soluble plasma EPCR |
| Navarro G. |
- |
PROS1 mutations that introduce a premature termination codon explain protein S deficiency by nonsense-mediated mRNA decay |
| Navarro S. |
- |
The 4678G/C polymorphism in the endothelial protein C receptor (EPCR) gene reduces the risk of venous thromboembolism in carriers of the factor V Leiden mutation |
| Navarro M. |
- |
Mutations in the shutter region of anti-thrombin result in severe episodic thrombosis and unlike other serpins in formation of disulfide-linked dimers |
| Navarro S. |
- |
Circulating activated protein C in Behcet's disease and risk of thrombosis |
| Navdaev A. |
- |
Labrirhagin, a protein with metalloprotease and disintegrin domains from Trimeresurus albolabris venom, activates platelets by a mechanism involving GPVI, aIIbbIII3 |
| Navdaev A. |
- |
Cross-linking of GPIb by echicetin/biotinylated-IgMk/avidin induces strong GPIIb/IIIa activation and platelet aggregation |
| Navickis R. J. |
- |
Comparative effectiveness of full-length and B-domain deleted factor VIII for prophylaxis a meta-analysis |
| Nawroth P. P. |
- |
Commercially available protein infusion solutions can be modified by nonenzymatic glycation which causes NFkappaB-dependent expression of procoagulant and inflammatory gene products |
| |
- |
Long-term RAGE-mediated NF-kB activation in diabetic neuropathy and its role in loss of pain perception |
| Naylor A. R. |
- |
The anti-platelet effect of aspirin is reduced following administration of heparin during carotid endarterectomy |
| Nazarko J. |
- |
Thrombolytic effect of AT1 receptor antagonists losartan and its metabolite EXP 3174 in rat |
| Nazeyrollas P. |
- |
Increasing the dosage of aspirin before percutaneaous coronary intervention: is there any effect in aspirin resistant patients? A randomized study |
| Necciari J. |
- |
Two sensitive chromogenic assays of fondaparinux sodium (Arixtra®), a new synthetic and selective inhibitor of factor Xa, in plasma |
| Nedelec J. |
- |
A dedicated system for standardized measurement of VASP phosphorylation in blood platelets and detection of thienopyridine resistance |
| Needham J. |
- |
Bleeding in patients with factor XII deficiency may relate to concomitant platelet function disorders if von Willebrand's disease is excluded |
| |
- |
Peri-operative bleeding in patients with Pseudomyxoma peritonei appears to relate to trauma induced hypofibrinogenemia |
| Needham J. |
- |
TAFI antigen levels in local hemophilia A and vWD population |
| |
- |
Hypercoagulability in inflammatory bowel disease |
| |
- |
Effect of warfarin anticoagulants on elements of the tissue factor pathway and other procoagulant markers |
| Neerman-Arbez M. |
- |
Congenital afibrinogenemia: expression and analysis of novel mutations affecting fibrinogen assembly or secretion |
| |
- |
Molecular analysis of factor XI deficiency in 8 Lebanese families: identification of two novel mutations |
| Negrescue E. |
- |
Regulation of megakaryocyte polyploidization and platelet release by the cytoplasmic tail of glycoprotein Iba |
| Negri E. |
- |
Hyperhomocysteinemia and other thrombophilic factors in Italian patients with inflammatory bowel disease |
| Negrier C. |
- |
Clinical evaluation of an advanced category recombinant FVIII, anti-hemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM) in surgical settings |
| |
- |
Monitoring the pharmacokinetic of inhibitor-bypassing agents with a new thrombin generation assay |
| |
- |
Human factor IX expression in megakaryocytes derived from electrophorated human hematopoietic cells |
| Negrier N. |
- |
Thrombin generation in von Willebrand diseases |
| Negrier C. |
- |
Three abnormal patterns for inversion breaking intron 1 of the FVIII gene |
| |
- |
Efficacy and safety profile of rAHF-PFM in the surgery setting |
| Négrier C. |
- |
Efficacy and safety of the first nanofiltered plasma-derived FVIII (FACTANE®) in previously treated haemophilia A patients |
| Negrier C. |
- |
Thrombin Generation Assay: Using Bedside Monitoring as a Dosage Guidance |
| Negrier C |
- |
Current processes and the future of manufacturing for recombinant clotting factors |
| Négrier C. |
- |
Deletion of residue Ala2201 in the factor VIII C2 domain impairs FVIII interactions with phospholipids and vWF and results in mild hemophilia A |
| Negrier C. |
- |
Clinical manifestation of severe hemophilia B ameliorated by Prothrombin 20210A |
| |
- |
In vitro flow cytometry and functional testing of fresh and cryopreserved platelets |
| |
- |
A retrospective evaluation of the use of B-domain deleted recombinant Factor VIII (ReFacto®) administered by continuous infusion during surgical procedures |
| |
- |
Determination of effective concentrations of recombinant factor VIIa (rFVIIa) for Glanzmann thrombasthenia patients by using thrombin generation in platelet-rich plasma (PRP) and platelet-poor plasma (PPP) |
| |
- |
Comparison of Clauss fibrinogen and fibrinogen measurement derived from aPTT and PT in diabetes mellitus and correlations with markers of glycemic equilibration |
| Négrier C. |
- |
Treatment of patients with inhibitors with FEIBA: the French experience from 1995 to 1999 |
| Negrotto S. |
- |
Prostacyclin protects basal and nitric oxide-induced megakaryocytes apoptosis |
| Negrotto S. |
- |
Characterization of the von Willebrand factor present in circulating PMN |
| Negrouk G. |
- |
Protection of a chimeric antihuman tissue factor monoclonal antibody against tissue factor-induced acute thrombosis in mice |
| Nehmiz G. |
- |
Pharmacokinetics of BIBR 953 ZW, the active form of the oral direct thrombin inhibitor BIBR 1048, in patients undergoing hip replacement |
| Neil M. |
- |
A single-center prospective study of clinical and genetic thrombophilic risk factors for deep venous thrombosis (DVT) in 510 patients undergoing elective lower limb surgery |
| |
- |
An evaluation of preoperative hemostatic variables as risk factors for deep venous thrombosis after elective lower limb arthroplasty |
| Neill E. |
- |
Postpartum levels of activated TAFI (TAFIa) in patient plasmas |
| Neilsen G. L. |
- |
Recombinant factor VIIa in management of acute CNS and GI bleedings during warfarin thromboprophylaxis: clinical and biochemical aspects |
| Nel M. J. |
- |
Ethnic differences in the frequencies of polymorphisms of protein S and protein C in South African populations |
| Nelissen R. G. H. H. |
- |
Thromboprophylaxis in orthopedic surgery: Clinical practice in the Netherlands |
| Nelson T. |
- |
Severe factor VII deficiency caused by a new point mutation combined with a previously undetected gene deletion |
| Nelson E. J. R. |
- |
Three novel missense mutations in the b-propeller domains of GPIIb (aIIb integrin) among three unrelated patients with Glanzmann thrombasthenia from southern India |
| Nemerson Y. |
- |
Role of BloodBorne Tissue Factor in Thrombus Propagation |
| Nemerson Y. |
- |
Induction of fractalkine by endothelial cells under shear stress |
| Nemery B. |
- |
Role of pulmonary inflammation on the peripheral thrombotic risk following intratracheal instillation of diesel exhaust particles |
| |
- |
Diesel exhaust particles deposited in the lung enhance thrombus formation in peripheral vessels in an in vivo model of vascular thrombosis |
| Nemmar A. |
- |
Diesel exhaust particles deposited in the lung enhance thrombus formation in peripheral vessels in an in vivo model of vascular thrombosis |
| |
- |
Role of pulmonary inflammation on the peripheral thrombotic risk following intratracheal instillation of diesel exhaust particles |
| Nemtsova V. |
- |
The influence of cyclooxygenase-2-selective nonsteroid anti-inflammatory drugs on bleeding complications in aspirin users |
| |
- |
Effect of etanercept on procoagulant activity and fibrinolysis in patients with rheumatoid arthritis |
| Nenci G. G. |
- |
Prevalence of thrombophilic genetic mutations in patients undergoing thrombotic events while on oral anticoagulants: a case-control study |
| |
- |
Oral anti-coagulant therapy with POC device and remote computer monitoring in the setting of the Italian National Health System (INHS) |
| |
- |
Interaction between thrombophilic genetic mutations and clinical bleeding in patients undergoing chronic oral anti-coagulant treatment |
| Nerme V. |
- |
Carboxypeptidase U (TAFIa) prevents fibrinolysis from proceeding into the propagation phase through a threshold-dependent mechanism |
| Nesbitt I. M. |
- |
Profile of mutations in a UK hemophilia A patient population |
| Nesbitt I. M. |
- |
Characterization of mutations in a cohort of type 2 von Willebrand disease patients |
| Nesbitt I. M. |
- |
A novel R2464C candidate von Willebrand factor mutation in families with von Willebrand disease |
| Nesbitt W. S. |
- |
Signaling events underlying thrombus formation |
| Nesheim M. |
- |
A study of the protection of plasmin from antiplasmin within an intact fibrin clot during the course of clot lysis |
| Nesheim M. E. |
- |
A ligand-induced conformational change in apolipoprotein(a) enhances covalent Lp(a) assembly |
| |
- |
Polymorphisms in the 3'-untranslated region of the TAFI mRNA modulate TAFI gene expression through control of mRNA stability |
| |
- |
Molecular dissection of the human TAFI promoter |
| |
- |
Effect of polymorphisms in the human TAFI 5'-flanking region on TAFI promoter activity |
| |
- |
The prothrombinase enhancing activity exhibited by VLDL derived from patients with the biphasic APTT waveform is due to increased anionic phospholipid exposure |
| |
- |
Factor Xa is profoundly protected from Antithrombinarixtra and antithrombin-Lovenox when incorporated into the prothrombinase complex |
| |
- |
Postpartum levels of activated TAFI (TAFIa) in patient plasmas |
| Nesova T. |
- |
Complex of Glycoprotein IIb/IIIa von Willebrand factor (GP IIb/IIIa-vWF) in blood of patients with ischemic heart disease |
| Nestoridi E. |
- |
Globotriasylceramide (Gb3) and blood-borne tissue factor (TF) colocalize with platelets during platelet adhesion/aggregation onto a collagen-coated surface exposed to flowing blood |
| Nestoridi E. |
- |
Shiga toxin with antecedent TNF-a induces enhanced tissue factor activity on human glomerular, but not on umbilical vein, endothelial cells |
| Netiazhenko V. Z. |
- |
Coagulation, fibrinolysis and platelet activity in aspirin-naive and prior aspirin users unstable angina patients, treated with unfractionated heparin |
| |
- |
Coagulation, fibrinolysis and platelet activity in aspirin-naive and prior aspirin users unstable angina patients, treated with unfractionated heparin |
| |
- |
Coagulation, fibrinolysis and platelet activity in aspirin-naive and prior aspirin users unstable angina patients, treated with unfractionated heparin |
| Neubauer I. |
- |
Additive anti-angiogenic effects of trapidil and cyproheptadine in the chick area vasculosa angiogenesis model |
| Neumann F. J. |
- |
Tissue factor stimulates migration by activation of the mitogen-activated proteinkinase p38 and the GTPase Rac1 |
| Neumann H. A. M. |
- |
Local changes in coagulation and fibrinolysis in patients with a previous deep venous thrombosis |
| Neumann F.-J. |
- |
Proteolysis of tissue factor pathway inhibitor-1 on circulating microparticles after thrombolysis in acute myocardial infarction contributes to thrombin formation |
| Neumivakin L. V. |
- |
Thrombolytic action of longolytin product of low fungi Arthrobotrys longa in rabbit thrombosis model |
| Neundörfer B. |
- |
Long-term RAGE-mediated NF-kB activation in diabetic neuropathy and its role in loss of pain perception |
| Neville B. |
- |
Species dependence on nitric oxide generation: pharmacological implications on animal modeling |
| Newall F. |
- |
Thrombolytic therapy with tissue plasminogen activator (tPA), analysis of safety and outcome in children |
| |
- |
Reference ranges for hemostatic parameters in children |
| |
- |
Arterial thromboembolic disease in infants and children |
| Newall F. |
- |
Anti-coagulation clinics for children achieve improved warfarin management |
| Newall F. |
- |
Prospective cohort study of paediatric venous thrombosis |
| Newhart A. |
- |
Performance evaluation of the new CoaguChek® PT.S-test on the CoaguChek® S system |
| |
- |
Equivalence of venous and capillary INR values determined with the new CoaguChek® PT.S-test on the CoaguChek® S system |
| Newman D. K. |
- |
Opposing effects of P-selectin and PECAM-1 on arterial thrombus growth and stability in vivo |
| Newman P. J. |
- |
Opposing effects of P-selectin and PECAM-1 on arterial thrombus growth and stability in vivo |
| Newman P. |
- |
PECAM-1 as a regulator of endothelial cell survival |
| Newman D. K. |
- |
Juxtaposition of phosphoserine and tyrosine in the Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 C-terminal Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) allows ITIM tyrosine phosphorylation but bars binding of the phosphatase, SHP-2 |
| Newman P. J. |
- |
Juxtaposition of phosphoserine and tyrosine in the Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 C-terminal Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) allows ITIM tyrosine phosphorylation but bars binding of the phosphatase, SHP-2 |
| Newton A. |
- |
Proteinprotein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA-binding |
| Ng H. |
- |
Patterns of cases and impact of venous thromboembolism (VTE) in a tertiary institution in Singapore: defying notions of VTE as a disorder of lower significance among Asians |
| Ng G. M. |
- |
Clinical profile of rare coagulation disorders in an Asian population |
| Ng B. L. |
- |
Coagulation and fibrinolysis during the menstrual cycle and the effects of increased body mass index |
| |
- |
Plasminogen activators, plasminogen activator inhibitor-1 and D-dimer levels in gynecological cancer |
| Ng H. |
- |
Thrombotic events associated with the use of recombinant factor VIIa in a single institution: a role for caution |
| Nguyen V. H. |
- |
Molecular basis of the bleeding disorder caused by Prothrombin-Vancouver |
| Nguyen F. |
- |
In terms of clinical impact, thromboplastins with an ISI close to 1 yield better results than thromboplastins with an ISI close to 2, in an external quality control campaign |
| Nguyen T. |
- |
The effect of dietary vitamin K1 on warfarin maintenance dose requirements |
| Nguyen P. |
- |
Thrombinography can differentiate bleeding from nonbleeding patients with prolonged APTT |
| Nguyen L. H. |
- |
Effects of full and partial substitution of the reactive center loop of alpha-1-proteinase inhibitor by that of heparin cofactor II on the inhibition of thrombin and activated protein C |
| Nguyen P. |
- |
Platelet function peculiarities throughout childhood: a flow cytometric study from healthy premature new-borns up to 15-year-old-children |
| Nguyen N. |
- |
Plasma hemostatic markers in patients with malignancy: correlation with tumor progression and response to treatment |
| Nguyen P. |
- |
Increasing the dosage of aspirin before percutaneaous coronary intervention: is there any effect in aspirin resistant patients? A randomized study |
| Nguyen N. |
- |
Plasma markers of hemostatic activation in patients with cancer and deep venous thrombosis |
| Ni H. |
- |
Increased fibronectin secretion but not cell surface expression in thrombin-activated platelets of hypofibrinogenemia patients |
| Ni H. |
- |
Autoantibodies to recombinant PSI domain but not to cytoplasmic tail of beta3 integrin cause immune thrombocytopenia |
| Nicham F. |
- |
Evaluation of automated measurement of ristocetin cofactor activity of von Willebrand factor on STA-R® in von willebrand disease: study in 154 patients |
| |
- |
Analytical validation of the automated measurement on STA-R of the ristocetin cofactor activity (VWF:RCo) of von Willebrand factor |
| Nichols T. C. |
- |
Cloning and expression of full-length recombinant porcine von Willebrand factor |
| |
- |
Comparative response of plasma VWF in normal and von Willebrand disease dogs to up-regulation of VWF mRNA by Interleukin-11 vs. WeibelPalade body release by Desmopressin (DDAVP) |
| |
- |
Hemophilia A: total correction in mice and partial correction in dogs with canine FVIII using a new AAV serotype |
| Nichols W. L. |
- |
Variability of clinical laboratory practice in testing for disorders of platelet function: results of a NASCOLA survey |
| Nichols T. C. |
- |
The development of pro-hemostatic lyophilized platelets with minimized risk for intravascular coagulation |
| Nicolaes G. A. F. |
- |
Changed inactivation pathway of factor Va by activated protein C in the presence of heparin |
| Nicolaes G. A. F. |
- |
Inefficient secretion and intracellular degradation of factor V |
| |
- |
H1299R mutation results in retention of mutant factor V molecule in the Golgi complex: a possible novel type of quantitative defect |
| |
- |
Impaired anticoagulant activity of factor V accounts for a large fraction of the APC resistance associated with the FV Leiden (R506Q) and R2 (H1299R) mutations |
| |
- |
Identification of the multimerin binding region within the C2 domain of human factor V using constructs generated by alanine scanning and site-directed mutagenesis |
| |
- |
Theoretical and experimental investigation of the D2194G subsitution in the C2 domain of coagulation factor V |
| |
- |
Functional properties of recombinant factor Va mutated in a potential calcium-binding site |
| |
- |
Functional characterization of recombinant factor V molecules mimicking the R2-haplotype |
| Nicolini A. |
- |
1286 prospective consecutive cases of venous thromboembolic disease at the single venous thromboembolic Unit of Reggio Emilia |
| Nielsen J. D. |
- |
Prolonged thromboprophylaxis with low molecular weight heparin (dalteparin) after major abdominal surgery: the FAME study |
| |
- |
In vitro effect of recombinant activated factor VII on thrombin generation and clot formation in blood from patients on vitamin K-antagonist therapy |
| Niemela K. |
- |
Relation of prothrombotic platelet polymorphisms to the first manifestation of Coronary Artery Disease in middle-aged males |
| Niermann D. |
- |
Induction of monocytic tissue factor (TF) expression: an additional mechanism of action of desmopressine acetate (DDAVP) |
| Niesen T. |
- |
Influence of anti-thrombin on platelet adhesion onto immobilized fibrinogen in simulated low flow in vitro system |
| Nieswandt B. |
- |
Inhibition of metalloproteases during platelet storage leads to better platelet recovery and improved platelet function upon transfusion |
| |
- |
Normal arterial thrombus formation in integrin a2-deficient mice |
| |
- |
Targeting of the collagen binding site on glycoprotein VI is not essential for in vivo depletion of the receptor |
| |
- |
Glycoprotein Ib and integrin a IIbb 3 contribute to GPVI-dependent vWF-collagen induced thrombus formation under flow |
| |
- |
Collagen-platelet interactions in vivo |
| Nieuwenhuis H. K. |
- |
Recombinant factor VIIa restores adhesion and aggregation of a IIbb 3-deficient platelets in vitro |
| |
- |
Enhancement of fibrinolytic potential in vitro by anticoagulant drugs targeting factor Xa, but not by those inhibiting thrombin or tissue factor |
| |
- |
The relation between clinical phenotype and genotype of severe hemophilia A |
| Nieuwland R. |
- |
Endothelial cell and monocyte-derived microparticles in severe dengue virus infections |
| |
- |
Antigenic characterization of endothelial cell-derived microparticles and their detection ex vivo |
| |
- |
Subpopulations of tissue factor-exposing microparticles from platelets and T-cells colocalize leukocytic antigens in uncomplicated human type 2 diabetes |
| |
- |
Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin layer chromatography |
| |
- |
Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner |
| |
- |
Recombinant truncated tissue factor triggers coagulation in normal human plasma via the extrinsic pathway |
| |
- |
Soluble tissue factor released by cultured human umbilical vein endothelial cells is microparticle-associated and triggers thrombus formation in vivo |
| Niglio A. |
- |
Increased intima-media thickness to show relationship between atherosclerosis and inflammation in a human model: patients affected by rheumatoid arthritis and absence of common markers of atherosclerosis |
| Niitsu Y. |
- |
Effects of CS-747, a novel P2Y12 receptor antagonist, on cerebral and peripheral arterial occlusive diseases in rats |
| Nijhuis S. |
- |
The calibrated Thrombogram: exact monitoring of thrombin generation in clotting platelet rich- and platelet poor plasma |
| Nijs A. |
- |
A new Von Willebrand ristocetin cofactor activity assay based on plasma glycocalicin |
| Nikiforov A. M. |
- |
Unusual persistent cell damages in irradiated rat endothelium as a model in study pathophysiology of atherosclerosis and thrombosis |
| Nikolaidis G. |
- |
Correlation between SVCAM, SICAM plasma levels, the outcome of treadmill test and the systolic function of left ventricular (LV) in patients with coronary artery disease |
| |
- |
Levels of plasma tissue activator plasminogen (tPA)- A useful marker in the differential diagnosis of chest pain (marker of plaque destabilization) |
| |
- |
Obesity and coagulation. Is there any correlation? |
| |
- |
Correlation SVCAM, SICAM plasma levels with the outcome of treadmill test and with attitudinal factors for coronary artery disease in patients without previous history of ischemic heart disease |
| Nikolic N. |
- |
Analytical comparison of recombinant and plasma-derived activated protein C (APC) |
| Nikus K. |
- |
Relation of prothrombotic platelet polymorphisms to the first manifestation of Coronary Artery Disease in middle-aged males |
| Nilsen D. W. T. |
- |
Changes in homocysteine and lipid peroxidation by n-3 polyunsaturated fatty acids (PUFAs) administered after an acute myocardial infarction |
| |
- |
Tissue factor is a major determinant of thrombogenicity following an acute myocardial infarction |
| Nilsson T. |
- |
Spiral computed tomography has a higher sensitivity and specificity than d-dimer in the diagnosis of acute pulmonary embolism |
| Nilsson G. |
- |
Global hemostatic tests, protein C and anti-thrombin in the intensive care unit setting; correlations and ability to predict outcome |
| Nilsson P. E. |
- |
Prolonged prophylaxis against VTE with enoxaparin in patients undergoing surgery for malignancy: 1-year survival study |
| Nilsson T. |
- |
A comparison of spiral computed tomography and latex agglutination D-dimer assay in acute pulmonary embolism using pulmonary arteriography as Gold Standard |
| Nimjaroenniyom N. |
- |
The use of recombinant activated factor VII for controlling life-threatening bleeding in dengue shock syndrome |
| Ninet J. |
- |
Identification and characterisation of MIP-1b and VE-Cadherin as important markers of acute rejection after human heart transplantation |
| Ning G. |
- |
Genetic and physical mapping of the platelet disorder in the fawn-hooded hypertensive rat |
| Nishino M. |
- |
Clinical presentation of type 1 von Willebrand disease (VWD) in obligatory carriers: final results from a collaborative, international, multicenter study |
| |
- |
Comparison of hemorrhagic symptoms in obligatory carriers of type 1 and type 3 von willebrand disease (VWD): results from a collaborative, international, multicenter study |
| Nishioka J. |
- |
Decreased expression of protein C inhibitor in renal cell carcinoma cells is partly caused by DNA methylation |
| |
- |
Measurement of tissue factor messenger RNA levels in leukocytes from patients with underlying diseases of disseminated intravascular coagulation |
| Nishioka J. N. |
- |
Usefulness of fully automated measurement of reticulated platelet using the whole blood |
| Nishiya K. |
- |
Factor V C2 domain contains major binding site for thrombin |
| |
- |
The hemostatic effectiveness of regular infusions of factor VIII concentrates in hemophilia A patients with high responder inhibitors |
| |
- |
M-thrombin (Tris-coupled thrombin) is a novel potent agonist of platelet activation with minimum effect on clot formation |
| Nitsche A. |
- |
The coordinated transcription of genes encoding regulators of cell cycle progression revealed by expression profiling upon calcium ionophore A23187 treatment of B lymphoblasts from a patient with Scott syndrome |
| Niwaya K. |
- |
Successful argatroban-anticoagulant management for left ventricular assist system implantation in two patients with heparin-induced thrombocytopenia type II |
| Nix B. |
- |
Platelet aggregation and ATP release in whole blood for diagnosis of bleeding disorders |
| Nobile De Santis M. S. |
- |
Intruterine Growth Restriction (IUGR) and thrombophilic polymorphisms |
| Nobori T. |
- |
Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with DIC |
| Nobori T. N. |
- |
Frequency of biphasic transmittance waveform in the APTT coagulation assay in the patients with underlying diseases of DIC |
| |
- |
Usefulness of fully automated measurement of reticulated platelet using the whole blood |
| Nobori T. |
- |
Measurement of tissue factor messenger RNA levels in leukocytes from patients with underlying diseases of disseminated intravascular coagulation |
| Noel A. |
- |
Plasminogen activator inhibitor PAI-1 as a regulator of urokinase in angiogenesis |
| Nogami K. |
- |
Factor V C2 domain contains major binding site for thrombin |
| Nogueiras T. |
- |
rFVIIa (Novoseven®) in the treatment of Glanzmann's Thrombastenia |
| |
- |
Treatment of acquired factor VIII inhibitor using Feiba and Prednisone |
| Noguti M. A. E. |
- |
Prothrombin mutation G20210A, and not factor V Leiden, is a significant risk factor for cerebral venous thrombosis in 27 Brazilian patients |
| Nokes T. |
- |
Dramatic improvement in the care and management of patients with DVT in a large UK hospital |
| Nolasco L. |
- |
Peptides from the C-terminal regions of ADAMTS-13 specifically block cleavage of ultra-large von Willebrand factor multimers on the endothelial surface under flow |
| Nolen J. D. L. |
- |
Single-dose use of recombinant factor VIIa (NovoSeven) for correction of hepatic-induced coagulopathies prior to minor, invasive procedures |
| |
- |
Use of constant infusion of recombinant factor VIIa (NovoSeven) in the management of a recurrent subdural hematoma in a patient with severe hepatic coagulopathy |
| Nomura S. |
- |
Platelet-derived microparticle preparations for enzyme-linked immunoassay, and the high PDMP level detected in unstable angina patients |
| Nomura M. |
- |
Differences in perioperative coagulation between Japanese and other ethnic groups undergoing laparoscopic cholecystectomy |
| Nonne C. |
- |
Evidence for a PLCg2-independent alpha2beta1-triggered signalling pathway contributing to platelet aggregation in response to collagen |
| Nony E. |
- |
Comparability study of two purification processes of a plasma-derived anti-thrombin |
| Nordenhem A. |
- |
The t-PA/PAI-1 complex in plasma in relation to risk of myocardial infarction as evaluated in the Stockholm heart epidemiological program (SHEEP) |
| Nordenhem A. |
- |
Prospective evaluation of t-PA/PAI-1 complex predicting myocardial infarction in controls included in the SHEEP study |
| Norstrøm E. |
- |
Inhibition by prothrombin of individual activated protein C-mediated cleavages in factor Va |
| |
- |
Effects of protein S and phospholipid on individual APC-cleavage sites in factor Va |
| |
- |
Effects of Factor Xa and protein S on the individual APC-cleavage sites of factor Va |
| Norstrom E. |
- |
Gla-domain mutated human protein C demonstrating enhanced inactivation of both factor Va and factor VIIIa |
| |
- |
Functional characterization of recombinant Factor V Liverpool: Ile350Thr, a novel mutation associated with thrombosis |
| |
- |
Severe thrombophilia in two brothers due to novel combination of mutations in factor V gene producing quantitative deficiency (Glu119Term) and decreased sensitivity to activated protein C due to a novel glycosylation site (Ile359Thr-FV Liverpool) |
| North R. A. |
- |
Inherited thrombophilias are not increased in idiopathic small for gestational age pregnancies |
| Nortier J. W. R. |
- |
Incidence of thrombosis in gastro-esophageal cancer: a cohort study of 649 patients |
| Nosaka S. |
- |
Different distribution of antithrombin and thrombomodulin in endotoxin-treated rat: effect of antithrombin and activated protein c concentrates and nafamostat mesilate |
| Nosál M. |
- |
Is infection a risk factor of acute ischemic stroke? |
| Notø A. T. W. |
- |
Interactions between tissue factor pathway inhibitor (TFPI) and lipoprotein lipase (LPL) in metabolism of very low density lipoproteins (VLDL) |
| Notø A. |
- |
Inflammation and endothelial dysfunction in patients with carotid stenosis |
| Notley C. R. P. |
- |
Clear familial co-segregation of the type 1 von Willebrand disease phenotype and VWF haplotypes in the Canadian type 1 VWD study |
| Notley C. |
- |
The type 1/type 2M von Willebrand disease dilemma: findings from the Canadian Type 1 VWD study |
| Notley C. |
- |
An ancient von Willebrand Disease (VWD) mutation that associates with a common haplotype in ~14% of type 1 VWD patients |
| Notoya A. |
- |
Synthetic inhibitors of coagulation factor Xa suppress thrombin generation without affection on initial thrombin forming time |
| Nounou M. |
- |
Single center review of clinicopathological characterization in 77 patients with positive lupus anticoagulant antibodies |
| Novakova I. R. O. |
- |
The Nijmegen low-titer factor VIII inhibitor assay: a highly sensitive assay for the detection of low-titer factor VIII inhibitors |
| |
- |
High-dose interferon-alpha induction treatment combined with ribavirin for chronic hepatitis C in congenital coagulation disorders. A randomized, double-blind, placebo-controlled clinical trial |
| |
- |
Higher reticulated platelet counts and enhanced expression of P-selectin in patients with immune thrombocytopenic purpura compared to patients with myelodysplastic syndromes |
| |
- |
Evaluation of the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic approach to determine Glanzmann Thrombasthenia in blood platelet lysates |
| |
- |
Long-term in vivo platelet presensitization may explain the mechanism of factor VIIa prophylaxis in factor VII-deficient patients |
| |
- |
Homocysteine concentrations are associated with increased t-PA and PAI concentrations in smokers |
| Novokhatny V. |
- |
Distinct dose-dependent effects of plasmin and TPA on coagulation and haemorrhage |
| Novokhatny V. |
- |
In vitro assessment of inhibitory potential of plasma and whole blood toward exogenous plasmin |
| Novokmet S. S. |
- |
Plateletscoronary endothelium interaction: focus on L-arginine:NO system |
| Novotny M. |
- |
A human factor VIII inhibitor tolerating the endogenous FVIII with a unique A2 domain substitution in CRM + hemophilia A |
| |
- |
The C1 domain substitution His2155Asp severely reduces factor VIII binding to von Willebrand factor |
| Nowak G. |
- |
Characterization of the urinary metabolites of dipetarudin |
| Nowak T. |
- |
Virus validation studies utilizing model viruses are relevant for west Nile virus |
| Nowak G. |
- |
Additive anti-angiogenic effects of trapidil and cyproheptadine in the chick area vasculosa angiogenesis model |
| |
- |
Determination of direct thrombin inhibitors like hirudin in plasma Comparison of the Ecarin Chromogenic Assay (ECA) with the Ecarin Clotting Time (ECT) and the Activated Partial Thromboplastin Time (APTT) |
| Nowak G. |
- |
PADA-HIT: A new POCT method for ultra-fast detection of HIT II antibodies |
| Nowak G. |
- |
PADA fast and quantitative monitoring of blood platelet adhesiveness |
| Nowak-Goettl U. |
- |
Elevated factor VIIIC and further prothrombotic risk factors in paediatric venous thrombosis and stroke: a multivariate analysis |
| |
- |
Sinus venous thrombosis in children a multifactorial etiology |
| Nowak-Göttl U. |
- |
Factor XII-deficiency is a risk factor for ischaemic stroke but not for venous thrombosis in children |
| Noya M. S. |
- |
Replacement therapy for surgery and delivery in three patients from a single family with R1374C type 2M von Willebrand disease (VWD): the role of PFA100 monitoring |
| Nozzoli C. |
- |
Hyperhomocysteinemia as a risk factor for TIA and stroke in patients with AF |
| N'Tita K. |
- |
Different thromboprophylaxis approaches in patients undergoing knee arthroscopy (KANT study): interim report of prospective randomized study |
| Nuñez L. |
- |
Acquired platelet dysfunction with eosinophilia in children: A tropical disease present in Venezuela |
| Nugent D. J. |
- |
A proposed mechanism for reduced bleeding of direct thrombin inhibitors as compared to heparin as measured by thromboelastography |
| Nugent D. |
- |
Paradoxical effect of Factor XIII replacement on clot initiation |
| Nugent D. J. |
- |
Coexistence of multiple hemostatic genetic risk factors does not increase risk of coronary heart disease: The ARIC Study results |
| |
- |
The laboratory evaluation of aspirin-resistance in normal, healthy subjects |
| Nurden A. T. |
- |
Glanzmann thrombasthenia: a study of two Portuguese families and identification of a new homozygous C insertion in exon 10 of the GPIIIa |
| Nurden A. T. |
- |
Triple heterozygosity in the alphaIIb gene of a patient with Glanzmann thrombasthenia and platelets with a low alphaIIbbeta3 content |
| Nurden P. |
- |
Type 2N von Willebrand disease due to compound heterozygosity for the frequent R854Q type 2N mutation and a new R763G mutation abolishing the cleavage of von Willebrand factor propeptide |
| Nurden P. |
- |
A deficiency of glycoprotein (GP) VI in platelets of a patient with gray platelet syndrome |
| Nurden A. |
- |
A deficiency of glycoprotein (GP) VI in platelets of a patient with gray platelet syndrome |
| Nurden P. |
- |
Clinical and laboratory findings in a new case of congenital amegakaryocytic thrombocytopenia (CAMT) |
| Nurmohamed M. T. |
- |
Thromboprophylaxis in orthopedic surgery: Clinical practice in the Netherlands |
| Nuss R. |
- |
Pilot introduction study of a needleless transfer device (BAXJECT) for reconstitution of Factor VIII concentrates for infusion |
| Nutescu E. A. |
- |
Factors that influence the prescribing of low-molecular-weight heparins (LMWHs) in community hospitals: opinions of physicians, clinical pharmacists, and formulary committee members |
| Nylander S. |
- |
The relative importance of P2Y12/P2Y1 in thrombin/ADP-induced platelet activation and true synergistic action in-between inhibition of P2Y12 and P2Y1 |