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I
Iacobelli M. - Molecular-weight dependence on the inhibition of procarboxypeptidase U by heparin and a polydeoxyribonucleotide derived antithrombotic agent (Defibrotide)
Iacoviello L. - Pharmacological and cellular bases of some anti-thrombotic properties of extravirgin olive oil: studies on oleuropein and hydroxytyrosol
Iacoviello L. - Polymorphisms of the interleukin 1-b gene, inflammatory and hemostatic response and the risk of premature myocardial infarction
Iacoviello L. - NAD(P)H oxidase C242T gene variations and cardiovascular protection
Iacoviello L. - Hyperhomocysteinemia is associated with the progression of peripheral arterial disease in type 2 diabetic patients
Iacoviello L. - Effect of extra virgin olive oil on experimental thrombosis and primary haemostasis in rats
Iampietro R. - A multicentre assessment of the endogenous thrombin potential using a continuous monitoring amidolytic technique
Iampietro R. - The modulation of lipopolysaccharide induced gene expression and protein production by anti-thrombin
Iannaccaro P. - Clinical data of subjects with Factor V Leiden or G20210A prothrombin mutation: a single institution experience
Iannaccone I. - Thrombosis do not recur at conventional dose oral anticoagulation (INR 2–3) in primary anti-phospholipid syndrome: comparison with inherited thrombophilia at similar INR
Iannaccone L. - FV plasma levels and the activated protein C resistance phenotype are modulated by the FV gene Asp79His polymorphism in presence of the FV Leiden mutation
  - Elevated plasma factor XIII relates to intima media thickness of carotid arteries in primary antiphospholipid syndrome
  - Pro-atherogenic role for IgG antioxidised-low-density-lipoprotein-beta-2-glycoprotein-I complex in primary antiphospholipid syndrome
Iba T. - Prediction of the organ dysfunctions by coagulation/fibrinolysis molecular markers at the beginning of sepsis
Ibberson J. - Transport of blood samples through a pneumatic tube system causes loss of platelet function
Ibrahim A. H. - Detection of Thrombomodulin (TM) Ala455Val polymorphism using sequence-specific primer–polymerase chain reaction (PCR) in patients with severe obstetric complications
Ibrahim K. - Mechanism of activation in Eastern tiger snake bite
Ibsen L. - Heparin-induced thrombocytopenia (HIT) in neonates and very young children undergoing congenital cardiac surgery: a likely under-recognized complication with significant morbidity and mortality: report of 4 sequential cases
  - Report of argatroban infusions for heparin-induced thrombocytopenia (HIT) diagnosed by functional assay in 2 congenital cardiac surgery patients, a neonate and a 5-month old
Ichinose A. - Expression pattern and intracellular localization of the A subunit for coagulation factor XIII
Ide J. - Thrombin-mediated Ca2+ responses in chick embryo cardiomyocytes and cardiofibroblasts
Ido M. - Activation of a novel 33-kDa SER/THR kinase by tyrosine kinase and calpain in thrombin-stimulated platelets
Ido M. - Decreased expression of protein C inhibitor in renal cell carcinoma cells is partly caused by DNA methylation
Ieko M. - Sensitivity of semiquantitative lupus anticoagulant test for the diagnosis of antiphospholipid syndrome
  - Synthetic inhibitors of coagulation factor Xa suppress thrombin generation without affection on initial thrombin forming time
Iglesias Varela M. L. - Inherited and acquired prothrombotic risk factors in women with early or late pregnancy losses
Ignatiev D. yU. - Dynamics of the extracellular matrix degradation with the participation of urokinase-plasmin system: a mathematical model
  - Optimization model for type IV collagen degradation: determination of kinetic constants
Ignjatovic V. - Reference ranges for hemostatic parameters in children
Ihantola M. - Relation of prothrombotic platelet polymorphisms to the first manifestation of Coronary Artery Disease in middle-aged males
Ihara A. - Clinical significance of endothelial hemostatic markers in patients with ischemic heart disease
Ihara H. - Increased expression of endogenous tissue-type plasminogen activator and matrix metalloproteinase 9 contribute to heparin-produced cerebral hemorrhage after focal cerebral ischemia in mice
  - Plasminogen activator inhibitor-1 promotes fibrosarcoma cell migration by modifying cellular attachment to vitronectin via a vb 5 integrin
Ihle A. - Evidence of C677T methylentetrahydrofolate reductase (‘MTHFR’) and hyperhomocysteinemia (HH) – causal or casual coexisting risk factors?
Iino S. - The natural anticoagulant Thrombomodulin has radical scavenging activity and acts as an antioxidant C-type lectin
Ijiri Y. - Various ratio of n-3/n-6 polyunsaturated fatty acid alters the tendency of thrombosis and progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse
Ijsseldijk M. J. W. - The low frequency allele of glycoprotein VI raises the threshold for platelet activation by collagen and collagen-related peptides
  - Human glycoprotein VI: identification and blockade of the collagen-binding surface
Ikaguri H. - Effect of a nitric oxide donor on platelet reactivity and spontaneous thrombolysis in patients with chronic renal failure
Ikarugi H. - A new global thrombosis test (GTT) shows impaired spontaneous thrombolytic activity in elderly and in habitual smokers
Ikarugi H. - GTT: A comprehensive in vitro haemostasis test, assessing platelet function, coagulation and thrombolytic activity from a single native blood sample
Ikeda Y. - Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lanka ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X
Ikeda Y. - Increased expression of endogenous tissue-type plasminogen activator and matrix metalloproteinase 9 contribute to heparin-produced cerebral hemorrhage after focal cerebral ischemia in mice
Ikeda Y. - A humanized monoclonal antibody against vWF A1 domain inhibits vWF:RiCof activity and platelet adhesion in human volunteers
Ikemura O. - A humanized monoclonal antibody against vWF A1 domain inhibits vWF:RiCof activity and platelet adhesion in human volunteers
Ilari I. - Rate of adverse events during OAT in patients with mechanical prosthetic heart valves replacement
Ilebekk A. - Localized short-term myocardial ischemia causes massive coronary t-PA release
Iliadis F. - Acute ischemic strokes: LMWHs or aspirin administration and laboratory follow-up
  - Acute ischemic strokes: LMWHs or aspirin administration and laboratory monitoring
Iliceto S. - Symptomatic chronic thromboembolic pulmonary hypertension after symptomatic pulmonary embolism: incidence and risk factors: a long-term follow-up study
Imai T. - Factor VIIa directly promotes thrombin burst in the presence of negatively charged phospholipids and factor Va
Imamura T. - New functions of neutrophils in inflammation: tissue factor-triggered clotting induction and elastase-mediated fibrinolysis
Imanaka T. - Intracellular behavior of anti-thrombin Morioka (Cys95Arg), a mutant protein causing type I deficiency: escape from intracellular protein degradation systems and accumulation within newly formed Russell's body-like structures
Imanaka H. - Successful argatroban-anticoagulant management for left ventricular assist system implantation in two patients with heparin-induced thrombocytopenia type II
Imberti D. - Visceral vein thrombosis: retrospective analysis of 53 cases in five Italian thrombosis
  - Incidence of newly diagnosed cancer after three months or one year of oral anticoagulation for a first episode of idiopathic venous thromboembolism
  - A double-blind placebo-controlled randomized study on the efficacy and safety of enoxaparin for the prevention of upper limb deep vein thrombosis in cancer patients with central vein catheter
  - Long-term clinical outcome of patients with pulmonary embolism: a prospective, multicenter study
  - Subcutaneous adjusted-dose unfractionated heparin vs. fixed-dose low-molecular-weight heparin in the initial treatment of venous thromboembolism
Inaba H. - Roles of the individual g-carboxyglutamic acid residues of factor VII
Inácio R. A. - Psychologic impact of thrombophilia screening in asymptomatic relatives of carriers of prothrombotic mutations
Inácio R. A. S. - Thrombotic risk in first-degree relatives of factor V Leiden (FVL) and factor II G20210A carriers
Inbal A. - FXIII promotes endothelial cell migration, proliferation, and inhibits apoptosis
Inbal A. - Prevalence of circulating procoagulant microparticles in allogeneic stem cell transplantation (alloSCT) for hemato-oncological malignancies
Ingelfinger J. R. - Globotriasylceramide (Gb3) and blood-borne tissue factor (TF) colocalize with platelets during platelet adhesion/aggregation onto a collagen-coated surface exposed to flowing blood
  - Shiga toxin with antecedent TNF-a induces enhanced tissue factor activity on human glomerular, but not on umbilical vein, endothelial cells
Ingerslev J. - Sensitivity and specificity of PFA-100® vs. bleeding time in the diagnosis of type 1 von Willebrand disease (VWD)
  - An improved multimeric analysis identifies a subgroup of patients with Type 1 von Willebrand disease characterized by reduced VWF:RCo/Ag ratio
  - Evaluation of a new quantitative, rapid test (VWF-LIA) for the diagnosis of type 1 VWD
  - Hyperhomocysteinemia (HH) down regulates thrombin generation. FII:C, FXII:C and FX:C are down-regulated in HH while FVII:C is unaffected by HH
  - Molecular and clinical markers for the diagnosis and management of type 1 von Willebrand's disease (VWD): The progress of a European collaboration
  - Co-segregation of Von Willebrands disease type 1 phenotype and Von Willebrand factor gene haplotypes: first results from the multicenter study molecular and clinical markers for the diagnosis and management of type 1 Von Willebrands disease
  - Recombinant factor VIIa in management of acute CNS and GI bleedings during warfarin thromboprophylaxis: clinical and biochemical aspects
  - In vitro expression of 4 novel mutations identified in type 1 von Willebrand disease patients
  - Hemophilia patients and the assessment of thrombin generation in platelet-rich plasma and platelet-poor plasma
Ingerslev J. - Phenotypic variation in real-time whole blood clot formation profiles in severe hemophilia. Response patterns following ex vivo addition of rFVIII and rFIX
Ingerslev J. - Real-time whole-blood coagulation following ex vivo hemodilution with plasma substitutes: reversal of the coagulopathy by a fibrinogen concentrate
  - Whole blood coagulation profiles in patients with thrombosis
Ingerslev J. - Development of inhibitors against factor VII in patient with severe factor VII deficiency
Ingerslev J. - Hand computer and Internet for collection and presentation of patient diary data in a Nordic clinical multicenter safety surveillance study of ReFacto®
  - Whole blood coagulation response patterns to ex vivo added recombinant factor VIIa in Hemophilia A, Hemophilia B, and other inherited coagulation factor disorders
  - Potential effect of recombinant factor VIIa in ex vivo reversal of pentasaccharide induced anticoagulation
  - A novel type 1 von Willebrand disease causing mutation (S49R) in the von Willebrand factor pro-peptide that affects von Willebrand factor multimerization and secretion
Ingerslev J. - Whole blood clot formation profiles in patients with Bernard Soulier's and Glanzmann's disease. Ex vivo intervention with platelets and recombinant factor VIIa
Ingerslev J. - Sample management and quality control in roTEG thrombelastography
  - Monitoring factor levels in haemophilia: potency assessment and assay variability
Ingersoll S. B. - Identification of a tissue factor ortholog in zebrafish, a potential new animal model of hemostasis and cancer
Ingersoll S. - Platelet CD40L and CD40 enhance tumor cell-induced coagulopathy and experimental metastasis
Iniesta J. A. - Genetic variations of the extra-large stimulatory G protein a-subunit and risk of thrombotic and hemorrhagic disorders
Inkaew B. - The factor V R2 allele (A4070G), factor V gene G1628A mutation, factor V Hong Kong (A1090G), factor V Cambridge (G1091C), the tissue factor pathway inhibitor gene C536T mutation and the risk of venous thrombosis in Thai patients
Innes A. J. - Dark chocolate inhibits platelet aggregation in healthy volunteers
Inoue O. - Integrin a2b1 stimulates platelet spreading through protein tyrosine phosphorylation and calcium mobilization
Insidioso M. - Transdermal hormone replacement therapy does not affect hemostasis and inflammation
Investigators RIETE - Management and outcome of patients with venous thromboembolism: a prospective registry including over 5000 consecutive patients
Iochmann S. - Quantitative evaluation of TFPI-2 and MMP-9 expression in nonsmall cell lung cancer
  - Transcriptional silencing of TFPI-2 gene by hypermethylation of the promoter in choriocarcinoma cells
  - Demonstration of a tissue factor pathway inhibitor-2 (TFPI-2) mRNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas
Ionescu A. - Warfarin-resistant factor VII is a potential risk factor for thromboembolism (TE) after prosthetic heart valve replacement
Iori I. - 1286 prospective consecutive cases of venous thromboembolic disease at the single venous thromboembolic Unit of Reggio Emilia
Iori A. P. - Thrombophilic screening in patients with paroxysmal nocturnal hemoglobinuria
Iori I. - Hyperhomocysteinemia and other thrombophilic factors in Italian patients with inflammatory bowel disease
Iorio A. - Hyperhomocysteinemia and other thrombophilic factors in Italian patients with inflammatory bowel disease
Iorio A. - Impairment of fibrynolytic capacity in experimentally induced ketoacidosis in continuous subcutaneous insulin infusion patients
Iorio A. - Recombinant activated Factor VII (rFVIIa) for the treatment of bleeding secondary to acquired factor VIII inhibitor
  - 1286 prospective consecutive cases of venous thromboembolic disease at the single venous thromboembolic Unit of Reggio Emilia
Iorio A. - Low molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: meta-analysis of the randomized comparisons with oral anti-coagulants
Iorio A. - Oral anti-coagulant therapy with POC device and remote computer monitoring in the setting of the Italian National Health System (INHS)
Iorio A. - Clinical quality assessment program for the oral anti-coagulant clinic: preliminary report of a multicentric Italian exercise
Iorio A. - Clinical and laboratoristic performance evaluation of three point-of-care devices for INR determination (Coagucheck, ProTime, Harmony)
Iqbal O. - The irrelevance of International Normalized Ratio in the monitoring of anti-IIa and anti-Xa drugs
  - Argatroban anticoagulation inhibits thrombin generation and its rebound during percutaneous interventional procedures
  - Alterations in intraplatelet Ca2+ mobilization by functional antiheparin-PF4 antibodies: Implications in the signaling mechanisms during HIT pathogenesis
  - Serine proteases–mediated serotonin release and its inhibition by argatroban and other direct thrombin inhibitors: Implications in the control of thrombogenesis
  - Interaction of thrombolytic agents with argatroban: pharmacological implications
  - Heparinase I digestion of tinzaparin: a novel approach to neutralize the anti-coagulant and potential hemorrhagic effects of low molecular weight heparin
  - Fibrinopeptide-A generation inhibition by anti-Xa drugs and its correlation with activated clotting time
  - Considerations in the standardization of the functional and immunologic assays for human procarboxypeptidase U. Diagnostic implications
  - Species dependence on nitric oxide generation: pharmacological implications on animal modeling
  - Prevalence of anti-Erythropoietin antibodies in end stage renal disease patients treated with recombinant Erythropoietin
  - Activated clotting time guided dosage optimization of a low molecular weight heparin (tinzaparin) for surgical and interventional indications
  - Effectiveness of polybrene neutralization of heparin and low-molecular weight heparin in plasma
Ireland H. - Polymorphisms in the thrombomodulin gene as risk factors for myocardial infarction (HIFMECH study)
Ireland H. - A thrombomodulin (TM) gene promoter variant (TM-33G > A) in type 2 diabetes
  - Soluble endothelial cell markers (sTM, sEPCR and sVWF) in type 2 diabetes
Irken G. - Life threatening mediastinal-retroperitoneal hemorrhage in a child with moderate hemophilia A and high titer inhibitor: successful management with recombinant activated factor VII
Ironside J. W. - Variant Creutzfeldt–Jakob disease and its transmission by blood
Isenhour T. - Disease genetics and recent advances in pharmacogenetics
Isermann B. H. - Biological and pathological roles of thrombomodulin
Isermann B. - Platelets and fibrinogen are not required for embryonic development but have distinct roles for placentation
Isermann B. H. - Altered vascular remodeling in hyperfibrinogenemic mice
Ishida H. - Real-time visualization of platelet shape changes occurring in response to their adhesion on immobilized type I collagen or von willebrand factor under controlled blood flow conditions
  - Dissolving effects of anti-GP IIb/IIIa agents on platelet thrombi formed on the collagen surface under blood flow conditions
Ishiguro K. - Ryudocan (syndecan-4) deficiency increases susceptibility to LPS-induced shock in mice
Ishihara H. - DX-9065a, a direct factor Xa inhibitor prevents both arterial and venous thrombosis in rats via blocking prothrombinase complex activity – comparison with fondaparinux, an antithrombin dependent factor Xa inhibitor
  - Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lanka ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X
Ishii H. - GTT: A comprehensive in vitro haemostasis test, assessing platelet function, coagulation and thrombolytic activity from a single native blood sample
  - Ligand for peroxisome proliferator-activated receptor-a (PPARa) Down-regulates tumor necrosis factor - a-induced pro-coagulant activation of tissue factor through inhibition of ap-1-dependent gene transcription in human endothelial cells
  - Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family
Ishii I.H. - Oxidized phospholipids in oxidized LDL down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RAR
Ishii H. - A new global thrombosis test (GTT) shows impaired spontaneous thrombolytic activity in elderly and in habitual smokers
  - EF6265: a new synthetic, potent and selective plasma CPB/TAFIa inhibitor
  - Effect of a nitric oxide donor on platelet reactivity and spontaneous thrombolysis in patients with chronic renal failure
Ishiwata S. - Thrombin-mediated Ca2+ responses in chick embryo cardiomyocytes and cardiofibroblasts
Ishizashi H. - Mutations of ADAMTS13 gene in four Japanese families with Upshaw–Schulman syndrome
Islam N. - CD39 ecto-nucleotidase activity (metabolizing ATP to ADP to AMP) constitutes a homeostatic mechanism for control of platelet reactivity, depending on the ratio of ADPase to ATPase activity. Results from patients with coronary artery disease
Ismail K. - Nine years experience at the AUB-MC vascular lab
Isobe H. - Antithrombin suppresses endotoxin-induced hypotension through the effect of calcitonin gene-related peptide
Isobe T. - Anti-platelet and anti-thrombotic effects of CS-747, a novel P2Y12 receptor antagonist, in combination with aspirin
Isobe K. - The effect of direct FXa inhibitor and direct thrombin inhibitor on TF induced DIC and venous thrombosis models in anesthetized rat – thrombin inhibitor enhance the platelet consumption in DIC model
  - Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse
Isordia-Salas I. - Domain 5 (D5) of high molecular weight kininogen (HK) induces aggregation of human platelets
  - A single point mutation of asparagine 511 to serine is responsible for the increased rate of cleavage of high molecular weight in Lewis rat, which is genetically susceptible to inflammatory stimuli
Israel S. - Final results from the Canadian hemophilia dose escalation prophylaxis trial
Israels S. J. - Anti-CD63 monoclonal antibodies inhibit platelet spreading on immobilized fibrinogen
  - Streptococcus sanguis-induced platelet signal transduction pathways involve both ITAMs and ITIMs
Israels S. J. - Procoagulant activity of neonatal platelets
Israels S. - Patterns of factor prophylaxis in the Canadian hemophilia A population
Isshiki I. - Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lanka ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X
Isvarlal P. - The prognostic value of platelet count drop in an intensive care unit
  - Coagulation inhibitor monitoring rationale in critical patients with severe sepsis
Itabe H. - Immunohistochemical expression of interleukin-10 (IL-10) in atherosclerotic intimas of human coronary arteries
Italia A. - Increased TAFI-dependent anti-fibrinolytic effect associated with the presence of an anti-FV antibody in a patient with severe thrombophilia
Italiano Jr J. - Birth of the platelet
Ito T. - Is an antithrombin substance (aFIIa) more hemorrhagic compared with an anti-factor Xa (aFXa) aent?: Differential inhibitory effects of these two agents against platelet activation
  - Rituximab reduces anti-phospholipid antibody (APA) titers and improves hypercoagulability in patients with anti-phospholipid syndrome (APS)
Ito M. - Androgen receptor-mediated suppression of tissue factor gene expression in male reproductive organs
Ito Y. - Activated protein C induces angiogenesis in vivo and in vitro
Ivanets T. Y. - Haemostasis parameters and different forms of Ovarian Hyperstimulation Syndrome
Ivanets N. V. - Haemostasis parameters and different forms of Ovarian Hyperstimulation Syndrome
Ivanets T. Y. - Hemostasis during first trimester of spontaneous pregnancy and pregnancy after IVF&ET
Ivanets N. V. - Hemostasis during first trimester of spontaneous pregnancy and pregnancy after IVF&ET
Ivanková J. - TAFI and diabetic nephropathy
  - Epidemiology of inherited thrombophilia in Slovakia
Ivaskevicius V. - Mutation profiling in congenital FXIIIA deficiency: detection of 6 novel mutations
Ivaskevicius V. - Genetic mechanisms underlying the clinical manifestation of hemophilia A in females
  - Genetic profiling of 20 patients with FVII deficiency by dHPLC and sequence analysis: detection of 7 novel mutations
Iverson G. M. - IgG isolated from plasmas of patients with the anti-phospholipid syndrome binds to domain I of beta2-glycoprotein I
Ivey L. M. - Prediction and prevention of thrombosis during pregnancy and oestrogen use
Ivey L. - Normal platelet-poor plasma correction studies in the laboratory diagnosis of lupus anticoagulant
Iwade K. - Usefulness of the prothrombin level measured by the carinactivase-1 method as the parameter of the coagulation activity during chronic warfarin therapy
Iwade M. - Differences in perioperative coagulation between Japanese and other ethnic groups undergoing laparoscopic cholecystectomy
Iwade K. - Differences in perioperative coagulation between Japanese and other ethnic groups undergoing laparoscopic cholecystectomy
Iwamura R. - Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747, a novel P2Y12 receptor antagonist
Iwanaga S. - Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis
Iwaniec T. - Immediate anti-coagulant and anti-inflammatory effects of simvastatin and fenofibrate in patients with coronary artery disease
  - Suppression of thrombin generation and fibrinolysis in patients with rheumatoid arthritis treated with anti-TNFa monoclonal antibody (Infliximab)
  - Thrombin generation in response to methionine loading test in patients with ischemic heart disease
  - Cerivastatin neither inhibits thrombin generation nor decreases markers of inflamation in patients with APS
  - Factor VIII activity and blood coagulation in patients on long-term oral anticoagulation
Iwase M. - Ryudocan (syndecan-4) deficiency increases susceptibility to LPS-induced shock in mice
Iwaszkiewicz A. - Time-dependent restoration of effective inhibition of blood platelet function after coronary artery by-pass grafting
Iwata H. - Purification and identification of coagulation factor IX-activating enzyme on the erythrocyte membranes
Iwata H. - Activation of factor IX by erythrocyte membranes is a trigger for coagulation at stasis
Iyengar S. - Use of constant infusion of recombinant factor VIIa (NovoSeven) in the management of a recurrent subdural hematoma in a patient with severe hepatic coagulopathy
Izaki K. - Activated factor VII enhances whole blood fibrinolysis due to urokinase-type plasminogen activator
Izon D. - Identification of individuals at high risk of developing Ischaemic Heart Diseases
Izzo M. - The G>T point mutation (Val34Leu) in the Factor XIII-A subunit gene in venous leg ulcers