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TopAddiction

The neurobiological basis for partial agonist treatment of nicotine dependence: varenicline. Foulds J Read article

The participation of health professionals in a smoking-cessation programme positively influences the smoking cessation advice given to patients. Puska PMJ, Barrueco M, Roussos C, Hider A, Hogue S Read article

An Intensive Group Therapy Program for Smoking Cessation using Nicotine. Han ES, Foulds J, Steinberg MB, Gandhi KK, West B, Richardson DL,  Zelenetz S, Dasika J Read article

TopAllergy

Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU). Day JH, Briscoe MP, Rafeiro E, Ratz JD Read article

TopCardiovascular Medicine

A meta-analysis of the vascular-related safety profile and efficacy of alpha-adrenergic blockers for symptoms related to benign prostatic hyperplasia - J Nickel et al Read for FREE 

Muddy waters: more stormy SEAS for ezetimibe
- Anthony S Wierzbicki Read for FREE

Diagnosis of insulin resistance in hypertensive patients by the metabolic syndrome: AHA vs. IDF definitions - C M Hwu et al Read for FREE

Gene therapy as a novel therapeutic option in the treatment of peripheral vascular disease: systematic review and meta-analysis - R Ghosh et al Read for FREE

Estimated 10-year cardiovascular risk in a British population: results of a national screening project - H. A. W. Neil et al Read for FREE

Heart failure is not a diagnosis - Patel K et al Read for FREE

Lipid-altering efficacy of ezetimibe/simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: the INFORCE study – Reckless J et al Read for FREE

Evaluation of the clinical outcomes of switching patients from atorvastatin to simvastatin and losartan to candesartan in a Primary Care setting: two years on - J. Usher-Smith, T. Ramsbottom, H. Pearmain et al Read for FREE

The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome- M. Thoenes, A. Oguchi, S. Nagamia, C. S. Vaccari, R. Hammoud, G. E. Umpierrez, B. V. Khan Read article

Health-related behaviours of people with diabetes and those with cardiometabolic risk factors: results from SHIELD- A. J. Green, D. D. Bazata, K. M. Fox, S. Grandy Read article

Systematic Review of Randomized, Double-blind Clinical Trials of Oral Agents Conducted in Patients with Pulmonary Arterial Hypertension – Torres F Read article

Predicting coronary heart disease risk using the Framingham and PROCAM equations in dyslipidaemic patients without overt vascular disease –Vrentzos G, Papadakis J, Ganotakis E, Paraskevas KI, Gazi IF, Tzanakis N, Nair DR, Mikhailidis DP Read article

The need for combination antihypertensive therapy to reach target blood pressures: what has been learned from clinical practice and morbidity-mortality trials? - Struijker-Boudier H, Ambrosioni E, Holzgreve H, Laurent S, Mancia G, Ruilope L M, Waeber B Read article

Evaluation of dyspnoea in a sample of elderly subjects recruited from general practice – Pedersen F, Mehlsen J, Raymond I, Atar D, Skjoldborg U, Hildebrandt P Read article

Determinants of cholesterol goal attainment at 12 months in patients with hypercholesterolaemia not at consensus goal after 3 months of treatment with lipid-lowering drugs - Lindgren P, Borgström F, Stålhammar J, Alemao E, Jönsson L Read article

Effect of enhanced external counterpulsation on medically refractory angina patients with erectile dysfunction. Lawson W, Hui JKC, Kennard ED, Soran O, McCullough PA , Kelsey SF Read article

The genetics of aspirin resistance. Goodman T, Sharma P, Ferro A Read article

Ranolazine: a novel agent that improves dysfunctional sodium channels. Pham D, Mehta M Read article

Different definitions of the metabolic syndrome and risk of first-ever acute ischaemic non-embolic stroke in elderly subjects. Milionis H,Kostapanos M,Liberopoulos E,Goudevenos J, Athyros V, Mikhailidis D, Elisaf M Read article

Inhibition of free fatty acids metabolism as a therapeutic target in patients with heart failure. Fragasso G Read article

Drug safety: who is responsible? Pitt B Read article

Evaluation of the cost savings and clinical outcomes of switching patients from atorvastatin to simvastatin and losartan to candesartan in a Primary Care setting. Usher-Smith J. A, Ramsbottom T, Pearmain H, Kirby M Read article

'Idiopathic' pericarditis - the clinician's challenge [nothing is idiopathic]. Spodick D, Lorbar M. Read article

Renin inhibitors: an important advance in hypertension treatment? Ferro A, Pitt B Read article

Prevalence of low HDL-cholesterol in patients with cardiovascular risk factors: the ECHOS (Etude du Cholesterol HDL en Observationnel) French Survey. M Farnier, P Garnier, C Yau, S Dejager, MP Verpilleux Read article

Treating dyslipidaemia in the setting of diabetes mellitus and cardiovascular disease: a less commonly perceived therapeutic perspective in clinical practice. Varughese G, Scarpello J Read article

Neurohormones and heart failure: the importance of aldosterone. Odedra K, Ferro A Read article

Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition. Ferro A, Gilbert R, Krum H Read article

A review of the management of patients after percutaneous coronary intervention. Wong EML, Wu EB, Chan WWM, Yu CM Read article

Sitaxsentan: an endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. O'Callaghan D, Gaine S Read article

FIELDS of dreams, fields of tears: a perspective on the fibrate trials. Wierzbicki A Read article

Initiation of hypertension treatment with a fixed-dose combination or its monocomponents - does it really matter? Scholze J, Bida M, Hansen A, Juncken D, Rangoonwala B, Ritz A, Schnitker J, Dörffel Y Read article

Thromboprophylaxis in atrial fibrillation: why, how, when and how can we do better? Watson T, Lip G Read article

Ivabradine - the first selective sinus node If channel inhibitor in the treatment of stable angina. Sulfi S, Timmis A Read article

Angiotensin II-receptor blocker dosages: How high should we go? Düsing R Read article

Cardiac syndrome X. Asbury EA, Collins P Read article

Achievement of English National Service Framework lipid-lowering goals: pooled data from recent comparative treatment trials of statins at starting doses. Hobbs FDR, Southworth H Read article

A review of the current evidence for the use of angiotensin-receptor blockers in chronic heart failure. Erhardt LR Read article

Redefining efficacy of antihypertensive therapies beyond blood pressure reduction - the role of angiotensin II antagonists. Conlin PR Read article

Review of efficacy of rosuvastatin 5 mg. Teramoto T, Watkins C Read article

Pivotal role of plasminogen-activator inhibitor 1 in vascular disease. Agirbasli M Read article

Efficacy and safety of ezetimibe co-administered with ongoing atorvastatin therapy in achieving low-density lipoprotein goal in patients with hypercholesterolemia and coronary heart disease. CRUZ-Fernandez JM, Bedarida GV, Adgey J, Allen C, Johnson-Levonas AO, Massaad R Read article

Genes and atherosclerosis: at the origin of the predisposition. Puddu P, Cravero E, Puddu GM, Muscari A Read article

The temporal relationship between erectile dysfunction and cardiovascular disease. Hodges LD, Kirby M, Solanki J, O'Donnell j, Brodie DA Read article

TopDermatology

A pilot study of high-dose short duration daptomycin for the treatment of patients with complicated skin and skin structure infections caused by gram-positive bacteria - D E Katz et al Read for FREE

Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Lewis-Jones S Read article

Current management of psoriasis in the United Kingdom: patterns of prescribing and resource use in primary care. Gillard SE, Finlay AY Read article

TopEndocrine Medicine

Is Adiposopathy ("Sick Fat") an Endocrine Disease?
- Harold Bays et al Read for FREE

How strong is the association between abdominal obesity and the incidence of type 2 diabetes? - N. Freemantle et al Read for FREE

The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome - D Preiss et al Read for FREE

Quality of life and depression of people living with type 2 diabetes mellitus and those at low and high risk for type 2 diabetes: findings from the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) - Grandy S et al Read for FREE

Do patients with diabetes wear shoes of the correct size?-  S. J. Harrison, L. Cochrane, R. J. Abboud, G. P. Leese. Read article

The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys. Bays HE, Chapman RH , Grandy S, the SHIELD Investigators' Group Read article

Testosterone and ageing: what have we learned since the Institute of Medicine report and what lies ahead? Miner M, Seftel A Read article

Factors influencing doctors' ability to calculate drug doses correctly. Wheeler DW, Wheeler SJ, Ringrose TR Read article

Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Scott R, Wu M, Sanchez M, Stein P Read article

Rimonabant: endocannabinoid inhibition for the metabolic syndrome. Wierzbikci A Read article

DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Barnett A Read article

Thiazolidinediones, insulin resistance and obesity: finding a balance. J Wilding Read article

The evolving role of testosterone in the treatment of erectile dysfunction. Shabsigh R, Rajfer J, Aversa A et al. Read article

Hyperhidrosis: a new and often early symptom in Fabry disease. International experience and data from the Fabry Outcome Survey. Lidove O, Ramaswami U, Jaussaud R et al. Read article

Closing the gap between clinical research and clinical practice: can outcome studies with thiazolidinediones improve our understanding of type 2 diabetes? Goldstein B Read article

Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C Read article

Inhaled insulin: new technology, new possibilities. Bellary S, Barnett B Read article

Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Wright E, Scism-Bacon JL, Glass LC Read article

Improving glucose management: Ten steps to get more patients with type 2 diabetes to glycaemic goal. Del Prato S, Felton A-M, Munro N, Nesto R, Zimmet P, Zinman B on behalf of The Global Partnership For Effective Diabetes Management Read article

Long-term glycaemic control with pioglitazone in patients with type 2 diabetes. Campbell IW Read article

Can primary care improve diabetes care? Kassianos G Read article

Type 2 diabetes mellitus: a cardiovascular perspective. Varughese GI, Tomson J, Lip GYH Read article

TopEthics

Ethics and pharmaceutical medicine - the full report of the Ethical Issues Committee of the Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the UK. Bickerstaffe R, Brock P, Husson J-M, Rubin I, Bragman K, Paterson K, Sommerville A Read article

TopGastroenterology

Prevalence and risk factors of metabolic syndrome in Brazilian and Italian obese adolescents: a comparison study - Ana R Damaso et al Read for FREE

Relationship between symptoms, subjective well-being and medication use in gastro-oesophageal reflux disease - Jones R, Liker H, Ducrotté P Read article

A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation. Malagelada JR Read article

Clinical manifestations and complications of gastroesophageal reflux disease (GERD). Malfertheiner P, Hallerback B Read article

Proton pump inhibitors: update on their role in acid-related gastrointestinal diseases. Robinson M Read article

Appropriate choice of proton pump inhibitor therapy in the prevention and management of NSAID-related gastrointestinal damage. Singh G, Triadafilopoulos G Read article

TopInfectious Diseases

Renal complications in HIV Jones R, Scott C, Nelson M, Levy J Read article

Why do patients fail HIV therapy? Waters L, Nelson M Read article

Insulin resistance and HIV infection: a review. M. Aboud, A. Elgalib, R. Kulasegaram, B. Peters Read article

Immunoglobulins and immunogenicity of pneumococcal vaccination in preschool asthma. Rose MA, Schubert R, Kujumdshiev S, Kitz R, Zielen S Read article

Management of advanced HIV disease: resistance, antiretroviral brain penetration and malignancies. Boffito M, Pillay D, Wilkins E Read article

Management of advanced HIV disease in patients with tuberculosis or hepatitis co-infection. Nelson M, Lipman M Read article

Risk factors of mortality for nosocomial pneumonia: importance of initial anti-microbial therapy. Lee S-C, Hua C-C, Yu T-J, Shieh WB, See L-C Read article

Efficacy of moxifloxacin for treatment of penicillin-, macrolide- and multidrug-resistant Streptococcus pneumoniae in community-acquired pneumonia. Fogarty C, Torres A, Choudhri S, Haverstock D, Herrington J, Ambler J Read article

TopNeurology

Diagnosis and management of Parkinson's disease dementia -
W Poewe et al Read for FREE

Emerging oral therapies for multiple sclerosis- Bruce Cohen, Peter Rieckmann Read article

EXACT: rivastigmine improves the high prevalence of attention deficits and mood and behaviour symptoms in Alzheimer's disease. Gauthier S, Juby A, Rehel B, Schecter R Read article

The importance of getting treatment for headache right. Kirby M Read article

Cardiac safety of rivastigmine in Lewy body and Parkinson's disease dementias. Ballard C, Lane R, Barone P, Ferrara R, Tekin S Read article

Rivastigmine monotherapy and combination therapy with memantine in patients with moderately severe Alzheimer's disease who failed to benefit from previous cholinesterase inhibitor treatment. Dantoine T, Auriacombe S, Sarazin M, Becker H, Pere J-J, Bourdeix I Read article

Diabetes mellitus and stroke. Idris I, Thomson GA, Sharma JC Read article

Focus on trial endpoints of clinical relevance and the use of almotriptan for the acute treatment of migraine. Sandrini G, Dahlüf CG, Mathew N, Nappi G Read article

Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years. Small GW, Kaufer D, Mendiondo MS, Quarg P, Spiegel R Read article

The influence of caregiver burden on sexual intimacy and marital satisfaction in couples with an Alzheimer spouse. Simonelli C, Tripodi F, Fabrizi A, Lembo D, Cosmi V, Pierleoni L Read article

TopOncology

NSAIDs and Breast Cancer: a Possible Prevention and Treatment Strategy - A. Agrawal, I. S. Fentiman Read for FREE

Prevention of secondary stroke and transient ischemic attack with antiplatelet therapy: the role of the primary care physician – Kirshner H Read article

Lipid lowering, statins and cancer. Wierzbicki A Read article

Optimising adjuvant endocrine treatment of breast cancer with aromatase inhibitors. Fentiman I Read article

The 2-week wait for suspected cancer: time for a rethink? Hanna SJ, Muneer A, Khalil KH Read article

Smoking and prognosis in women with breast cancer. Fentiman IS, Allen DS, Hamed H Read article

The what, why and how of Aromatase Inhibitors: hormonal agents for treatment and prevention of breast cancer. Fabian CJ Read article

Chemotherapy for the treatment of hormone-refractory prostate cancer. Chowdhury S, Burbidge S, Harper PG Read article

Access to expensive drugs in the NHS: myths and realities for cancer patients. Mehta AB, Low E Read article

TopPain Medicine

Efficacy and tolerability of lumiracoxib in the treatment of primary dysmenorrhoea. Bitner M, Kattenhorn J, Hatfield C, Gao J, Kellstein D Read article

TopPalliative Care

Aprepitant in antiemetic combinations to prevent chemotherapy-induced nausea and vomiting. Olver IN Read article

TopPsychiatry

Clinical Assessment and Treatment of ADHD in Children - Smoot L,  Boothby L, Gillett C Read article

Schizophrenia, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and number needed to treat: how can CATIE inform clinicians? Citrome L, Stroup S Read article

Duloxetine 60 mg once daily in the treatment of milder major depression disorder. Perahia DGS, Kajdasz DK, Walker DJ, Raskin J, Tylee A Read article

What are the barriers faced by general practitioners in treating depression and anxiety in Hong Kong? Wong SYS, Lee K, Chan K, Lee A Read article

Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview. Carrasco J-L, Sandner C Read article

Antidepressants and seizures: emphasis on newer agents and clinical implications. Montgomery S Read article

Aripiprazole in schizophrenia: consensus guidelines. Travis MJ, Burns T, Dursun S, Fahy T, Frangou S, Gray R, Haddad PM, Hunter R, Taylor DM, Young AH Read article

Efficacy of escitalopram in patients with severe depression: a pooled analysis. Llorca P-M, Azorin J-M, Despiegel N, Verpillat P Read article

The coming of age of a joint elderly medicine–psychiatric ward: 18 years’ experience. Hanna S, Woolley R, Brown L, Kesavan S Read article

Respiratory Medicine

Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study - A I Blamoun et al Read for FREE

Long-term tolerability of inhaled human insulin (Exubera) in patients with poorly controlled type 2 diabetes - Barnett A, Lange P, Dreyer M, Serdarevic-Pehar M Read article

The natural history of asthma from childhood to adulthood - Koh M, Irving L Read article

Immunoglobulins and immunogenicity of pneumococcal vaccination in preschool asthma. Rose MA, Schubert R, Kujumdshiev S, Kitz R, Zielen S Read article

Sitaxsentan: an endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. O'Callaghan D, Gaine S Read article

Asthma and COPD: differences and similarities. With special reference to the usefulness of budesonide/formoterol in a single inhaler (Symbicort) in both diseases. Decramer M, Selroos O Read article

Short-acting beta2-agonist and oral corticosteroid use in asthma patients prescribed either concurrent beclomethasone and long-acting beta2-agonist or salmeterol/fluticasone propionate combination. Angus R, Reagon R, Cheesbrough A Read article

TopRheumatology

A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis: 24-month results from FACTS-International – Reid D et al Read for FREE

Etanercept in arthritis. Scott DL Read article

TopUrology

Benign prostatic hyperplasia evaluation, treatment and association with sexual dysfunction: practice patterns according to physician specialty – Seftel A et al Read for FREE

Cardiovascular outcomes among sildenafil users: results of the International men's health study
M. A. Mittleman, M. Maclure, M. A. Lewis et al Read for FREE

Patterns of switching phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: results from the Erectile Dysfunction Observational Study- D. Hatzichristou, J. M. Haro, A. Martin-Morales, A. von Keitz, A. Riley, J. Bertsch, M. Belger, A. M. Wolka, A. Beardsworth Read article

Current safety and tolerability issues in men with erectile dysfunction receiving PDE5 inhibitors - Hellstrom W J G Read article

A Practical Guide to the Evaluation of Male Lower Urinary Tract Symptoms in the Primary Care Setting – Rosenberg M, Staskin D, Kaplan S, MacDiarmid S, Newman D, Ohl D Read article

Prevalence of lower urinary tract symptoms and prostate enlargement in the primary care–  Naslund M, Gilsenan A, Midkiff K, Bown A, Wolford E, Wang J Read article

Prevalence of storage and voiding symptoms among men aged 40 years and older in a US population-based study: results from the Male Attitudes Regarding Sexual Health study - Glasser D, Carson C, Kang J H, Laumann E O Read article

Identification and diagnosis of premature ejaculation Rosenberg M, Sadovsky R Read article

Erectile dysfunction correlates with left ventricular function and precedes cardiovascular events in cardiovascular high-risk patients.  Baumhäkel M, Böhm M Read article

Lower urinary tract symptoms, incontinence and falls in elderly people: time for an intervention study. Morris V, Wagg A Read article

The aetiology of premature ejaculation and the mind-body problem: implications for practice Rowland D, Motofei I Read article

Public, patient, and professional attitudes towards the diagnosis and treatment of enlarged prostate: a landmark national US survey. S Kaplan, M Naslund Read article

Overactive bladder: the importance of new guidance. M Kirby, W Artibani, L Cardozo, C Chapple, DC Diaz, D de Ridder, M Espuòa-Pons, F Haab, C Kelleher, I Milsom, P van Kerrebroeck, M Vierhout, A Wagg Read article

The evolving role of testosterone in the treatment of erectile dysfunction. Shabsigh R, Rajfer J, Aversa A et al. Read article

Epidemiology, prescribing patterns and resource use associated with overactive bladder in UK primary care. Odeyemi IAO, Dakin HA, O'Donnell RA, Warner J, Jacobs A, Dasgupta P Read article

Tolterodine extended release improves patient-reported outcomes in overactive bladder: results from the IMPACT trial. Roberts R, Bavendam T, Glasser DB, Carlsson M, Eyland N, Elinoff Read article

Efficacy, tolerability and safety of darifenacin, an M3 selective receptor antagonist: an investigation of warning time in patients with OAB. Zinner N, Susset J, Gittelman M, Arguinzoniz M, Rekeda L, Haab F Read article

Laparoscopic upper urinary tract surgery for benign and malignant conditions. Does aetiology have an effect on health-related quality of life? Sahai A, Tang S, Challacombe B, Murphy D, Dasgupta P Read article

Integrating partners into erectile dysfunction treatment: improving the sexual experience for the couple. Dean J, Rubio-Aurioles E, McCabe M, Eardley I, Speakman M, Buvat J, Sáenz de Tejada I, Fisher W Read article

Understanding patient and physician perceptions of benign prostatic hyperplasia in Europe: The Prostate Research on Behaviour and Education (PROBE) Survey Emberton M, Marberger M, de la Rosette J Read article