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Evaluation of H1N1 pandemic influenza cases hospitalized in an infectious diseases clinic

Abstract number: R2376

Akinci E., Kayaaslan B.U., Yetkin M.A., Yilmaz S., Aliravci D., Yildiz S., Ulgen F., Eren S.S., But A., Yilmaz G.R., Bodur H.

Objective: The H1N1 pandemic influenza virus is a new influenza virus causing illness in people. This virus was first detected in Mexico in April 2009. It is spreading from person-to-person worldwide. In Turkey, the number of cases is increasing day by day and 73 patients died until 16th October.

Methods: In this prospective study, H1N1 pandemic influenza cases hospitalized in our clinic between October and November 2009 were evaluated. During this period, totally 85 patients having severe disease were hospitalized with suspicion of H1N1 pandemic influenza. Of these patients, 40 had positive nasopharyngeal swab specimen for H1N1 virus by PCR test.

Results: The age range of the H1N1 cases were between 17–77 years and 30 (75%) were female. Twelve (40%) patients were pregnant. Underlying disease was present in 12 (30%) patients. Fifteen patients (38%) had history of contact with H1N1 positive people. At the admission, the duration of complaints was between 1–10 days. The most frequent complaints were fever (90%), myalgia (90%), cough (85%), headache (85%) and sore throat (75%). Physical examination revealed fever (85%), oropharingeal hyperemia (60%), shortness of breath (18%) and crepitan rales (28%) on lung auscultation. In laboratory tests, leucopenia (20%), thrombocytopenia (15%), elevation of liver enzymes (18%), and hyperglycemia (24%) were detected. Most of the patients (80%) were treated with oseltamivir and 55% were given the treatment in the first 48 hours. The only complication of H1N1 infection was pneumonia. Pneumonia was detected in 35% of the patients and 60% were administered antibiotics. Two patients needed mechanical ventilation and one died. The risk factors for development of pneumonia during H1N1 pandemic influenza infection are shown in table 1.

Conclusion: Pneumonia is the most important complication of H1N1 pandemic influenza and the risk is high in the patients with hyperglycemia or an underlying disease.

Table 1: Risk factors for development of pneumonia in H1N1 pandemic influenza

Risk factorsPatients without pneumonia (n = 26)Patients with pneumonia (n = 14)p value
Female gender21 (80.8%)9 (64.3%)0.220
Pregnancy8 (38.1%)4 (44.4%)0.528
Underlying disease6 (22.9%)6 (42.9%)0.047
Initiation of oseltamivir in 48 h13 (50%)9 (64.3%)0.386
Hyperglycemia1 (5.3%)7 (50%)0.005

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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