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Acinetobacter-associated infections in the Republic of Belarus: state of the problem

Abstract number: R2170

Objectives: The purpose of our research was to evaluate Acinetobacter baumannii antibiotic resistance level in hospitals of the Republic of Belarus.

Methods: The subject of the study was a group of patients with clinical and laboratory documented nosocomial infections caused by A. baumannii. All patients were treated in 12 Minsk hospitals between December, 2008 and July, 2009. The total number of researched patients is 73 (65.7% males; middle age 51.7±4.4 years old). Pathogen identification and antibiotic resistance surveillance were performed at the microbiological laboratory of the Institute of Antimicrobial Chemotherapy (Russian Federation). Strains collected from different specimen sources of the same patient were excluded.

The isolates were identified by conventional methods. Antimicrobial resistance was evaluated by disk-diffusion method and determined according to the guidelines of the National Committee for Clinical Laboratory Standards (NCCLS, USA). Intermediately susceptible isolates were recognized as resistant.

Results: None of the tested antibiotics achieved high activity (geqslant R: gt-or-equal, slanted80% susceptible) against nosocomial isolates of A. baumannii. The most of the examined strains were resistant to ceftazidime (91.7%), ciprofloxacin and amikacin (89% and 86.8% respectively). Susceptibility to gentamicin and carbapenems was relatively higher, but also under 50%. So 37% of the collected isolates were susceptible to gentamicin, 47.9% to imipenem and 46.6% to meropenem.

The difference in susceptibility to carbapenems was documented in three cases. Two strains were imipenem-susceptible and one strain was meropenem-susceptible.

It's interesting, that 9 of 73 collected isolates were susceptible only to gentamicin. It was also active against 14 carbapenem-resistant strains.

Conclusion:A. baumannii isolates from Minsk hospitals are characterized by high resistance to all studied antibiotics. We found out, that carbapenems have the highest activity against nosocomial strains of A. baumannii. It seems that gentamicin activity is relatively high, because it's not commonly used during the last ten years in our country. However, the resistance level to these antimicrobials was extremely high.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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