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Assessment of prognosis of tetanus and its related factors among Albanian adults

Abstract number: P2108

Objective: To assess the associated factors with prognosis of tetanus among the adult population of Albania.

Methods: All reported cases of tetanus (N = 64) hospitalized in the regional hospitals of Tirana (the Albanian capital), Shkodra (main district in north Albania) and Korca (one of the main districts in Southeast Albania) for the period 1984–2004. Four patients were excluded from the analysis due to missing information on prognosis. Data on prognosis-related factors included age, sex, incubation period, onset period, as well as location and type of wounds. Multivariable-adjusted binary logistic regression was used to asses the independent association of prognosis (survival vs. death) with covariates.

Results: The overall case-fatality rate was 38.6%. It was higher among older individuals (P < 0.01), and in those with a shorter incubation period (<11 days; P < 0.01) and with infected wounds (P = 0.03). There was no association, however, with location of wounds. Upon simultaneous adjustment for all covariates, age (>50 years vs. <50 years) and a shorter incubation period (<11 days vs. 11–20 days) were positively related to case-fatality (OR = 3.4, 95% CI=1.23–5.13 and OR = 2.41, 95% CI=1.19–4.37, respectively), whereas the association with infected wounds was not statistically significant any further (P = 0.13).

Conclusions: Age, incubation period and type of wound are important factors related to prognosis of tetanus in Albanian adults. Health care practitioners should actively seek information on prognostic characteristics of patients with tetanus in order to institute effective and prompt treatment of this disease.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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