Distribution of pertussis antibodies among Iranian children of different age groups

Abstract number: P2013

Eslamifar A., Aghakhani A., Banifazl M., Khadem-Sadegh A., Ramezani A.

Objective: Pertussis is a highly communicable, vaccine-preventable respiratory disease characterized by paroxysmal cough often accompanied by inspiratory whoop and posttussive emesis. Although the largest number of reported cases is among young infants, the most dramatic increase in pertussis incidence has been reported among adolescents and young adults. In this study we determined the distribution of antibody levels against pertussis antibodies among children of different age groups in Tehran, Iran.

Methods: Plasma samples of 833 children (459 male and 374 female) between ages of 6–20 years were tested for the presence of pertussis toxin (PT), filamentous hemagglutinin (FHA) and different lipopolysaccharides (LPS) IgG antibodies by Enzyme-linked immunosorbent assay (ELISA). All cases vaccinated five times with DTP vaccine. The pertussis antibodies >24 U/ml was considered positive. The children were separated to three age groups: Group 1 (6.0–10.9 years; n = 361), Group 2 (11.0–15.9 years; n = 284) and Group 3 (16.0–20.9 years; n = 188).

Results: The overall prevalence of pertussis antibodies was 45.5% (95% CI: %42.1-%48.9). The mean antibody titer was 43.3±47.8 U/ml. Pertussis antibodies prevalence rates according to age groups were as follows: Group 1; 39.1%, Group 2; 45.8% and Group 3; 57.4%. Pertussis antibodies positivity in terms of age groups was significantly different from each other (P < 0.001) and significant elevation in pertussis antibodies rates was observed with increasing age. For all age groups, there was no statistically significant difference between genders regarding to pertussis antibodies positivity.

Conclusion: Our study showed that Bordetella pertussis infection is widespread and on the rise in Iranian adolescents and young adults. Booster vaccination of this age group with acellular pertussis vaccines appears to be the most logical approach to disease prevention in adolescents and control the circulation of the organism.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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