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Condyloma acuminatum caused by HPV13: acasereport

Abstract number: P1991

Blioumi E., Chatzidimitriou D., Gavriilaki E., Kalekou H., Markopoulos A., Nikoloussi-Emmanouil E., Diza E., Antoniades D.

Introduction: Condylomata acuminata are benign proliferative lesions of the stratified squamous epithelium of the genitalia, the perianal region, mouth and larynx, induced by human papillomavirus (HPV). HPV types usually detected are: 2, 6, 11, 16, 18, 31, 33, 51, 53, 54. Herein we present a case of an oral condyloma accuminatum HPV13, consisting in the first description of HPV13 as an etiological factor of condyloma acuminatum.

Material and Methods: We describe an 18-year-old female patient with multiple non-tender oral lesions, reporting condylomas of the perianal region, anorexia and depression in her medical history.

Clinical examination revealed multiple, non-tender, wide-based exophytic nodules, with a normal colour and a size of 0.2–0.8 cm, found on the labial mucosa, the buccal mucosa, the lateral surface of the tongue and on either side of the lingual frenum.

The lesions were surgically excised. Sections of paraffin-embedded tissue were stained by hematoxylin-eosin stain for histopathological examination. DNA extracted from the paraffin-embedded tissue was amplified by polymerase chain reaction (PCR) in standard protocols. Nested PCR, using primers (MY09/MY11 and GP5+/GP6+) targeting the L1 gene, and sequencing were conducted.

Results: From clinical and histopathological examination condylomata acuminata were diagnosed. HPV infection was confirmed by nested PCR. Sequencing revealed HPV type 13.

Conclusions: It should be emphasized that to our knowledge, oral condyloma acuminatum induced by HPV13 has never been reported.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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