Evaluation of Quantiferon-gold (tuberculin skin test) for the identification of latent tuberculosis infection in would-be transplant recipient patients referring to an Iranian transplant clinic from September 2007 to December 2008

Abstract number: P1832

Ahmadinejad Z., Razaghi M., Jafarian A.

Introduction and Objective: Two billion people carry the Tuberculosis (TB) bacteria. The rate of tuberculosis in solid organ transplant recipients has been estimated to be 50-fold higher than in the general population. Diagnosis & treatment of Latent Tuberculosis Infection (LTBI) are the most important strategies to control TB in transplant candidate patients. In this study we aimed to compare Tuberculin Skin Test (TST) with QuantiFERON-TB Gold In-Tube (QFT) in the detection of LTBI in those patients.

Patients and Methods: Patients at the transplant clinic at the Imam Khomeini Hospital, Tehran, Iran between 2008 and 2009 were eligible for inclusion in the study if they were on the waiting list of transplantation. Patients were screened for LTBI with both QFT & TST. Concordance between test results & variables associated with test discordance were assessed.

Results: A total of 61 patients were enrolled in the study. In 10 patients the TST was not read. So, complete results were available for 51 patients. Average age was 40.2±13.2 years. Thirty patients (58.8%) were male. Four patients (7.8%) had positive TST & 7 patients (13.7%) had positive QFT. Two patients (5.9%) had indeterminate QFT. Overall agreement between tests was 82.4% (k = 0.091, p = 0.495). Discordant test results were seen in 3 TST positive/QFT negative patients & in 6 TST negative/QFT positive patients.

Conclusion: Overall agreement between test results was high, but its percentage was not significant based on p-value (p > 0.05) & k value (k < 0.4) represented poor agreement. Thus, neither of the two tests is recommended to the patients on waiting list as a more preferable test to detect LTBI. The decision to select QFT or TST will depend on the purpose of testing & resource availability.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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