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Antimicrobial susceptibility profiles in Streptococcus agalactiae invasive and colonizing strains from Greece: a 6year study

Abstract number: P1682

Vourli S., Tarpatzi A., Tsiveriotis K., Bompola M., Bournas N., Salamalekis G., Zerva L.

Objectives:Streptococcus agalactiae (Group B Streptococcus, GBS) is an important pathogen during the perinatal period, but it is also responsible for various invasive infections, most frequently skin and soft tissue infections, in non-pregnant adults. Most GBS strains are susceptible to penicillin, but resistance to erythromycin and clindamycin seems to be increasing. Few data on antimicrobial resistance of strains isolated in Greece are available. We present antimicrobial susceptibility profiles of GBS isolates from a 730-bed tertiary hospital of Athens.

Material: We studied 189 GBS isolates collected in the Clinical Microbiology Laboratory of our hospital from 2004 to 2009. Ninety-three of these were consecutively isolated from routine clinical specimens (urine, vaginal swabs, blood, synovial fluid and pus), and the remaining 96 from the colonisation screening of pregnant women (performed from 2008 to 2009).

Identification and antimicrobial susceptibility testing were carried out by the Phoenix ™100 automated system. Medical files of GBS-positive patients were retrieved from the hospital records and all information concerning the clinical significance of the isolates was collected.

Results: Overall, antimicrobial susceptibility results were available for 145 out of 189 GBS isolates. No penicillin, ampicillin, cefazolin or vancomycin resistance was observed in any of the examined strains. Twenty-eight strains (19.3%) were found to be erythromycin resistant. Only 9 out of the 93 clinical isolates (2 isolated from blood, 1 from synovial fluid and 6 from pus) were considered as invasive, after review of the medical records, and they were susceptible to all antibiotics tested.

Conclusions: Taking into account the size of our hospital, the rate of GBS invasive infections in non-pregnant adults appears to be low, according to our findings. A high percentage of erythromycin resistant was noticed, which is consistent with results coming from studies in other countries. Notably, invasive isolates were more susceptible than non-invasive ones.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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