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Antibacterial resistance among Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis from Kuwait and 5 centres in Turkey: results from the Survey of Antibiotic Resistance (SOAR), 20072009

Abstract number: P1677

Gur D., Tunger A., Aydemir S., Soyletir G., Altinkanat G., Bayramoglu G., Aydin F., Kayacan C., Aktas Z., Mokaddas E., Acar A., O'Brien D.

Objectives: Antibiotic resistance among community-acquired respiratory tract pathogens such as Streptococcus pneumoniae (SP) and Haemophilus influenzae (HI) is a worldwide problem. Moraxella catarrhalis (MC) remains one of the three leading causes of acute otitis media (AOM) in children. SP, HI and MC data from the SOAR programme are reported.

Methods: MICs for various antimicrobials were determined using Etest; disk susceptibility testing was performed according to CLSI guidelines. Susceptibility was assessed using CLSI interpretive criteria.

Results: 524 SP, 418 HI and 67 MC strains were collected from five centres in Turkey. Overall, 47.2% (247/524) of SP were penicillin-susceptible and 52.8% (277/524) were penicillin-nonsusceptible (PNSP) based on CLSI 2009 oral penicillin breakpoints. Based on CLSI 2009 IV penicillin breakpoints, 99.2% (520/524) were susceptible to penicillin. PNSP prevalence was highest (64.8%; 59/91) in Istanbul but lowest (42.7%;35/82) in Trabzon in Turkey. Overall, susceptibility to amoxicillin/clavulanate (XL), cefuroxime (XM), and clarithromycin (CH) was 97.7% (512/524), 64.7% (339/524), and 61.9% (324/524), respectively. The level of non-susceptibility to ofloxacin (OF) was 11.1% (58/524). A total of 418 HI isolates were collected of which 2.6% (11/418) produced b-lactamase (BL). Overall, 9 isolates (2.2%) were ampicillin resistant but BL negative (BLNAR). Overall, susceptibility to XL, XM and OF was 100% (418/418), 97.1% (406/418) and 99.8% (417/418), respectively. All MC strains were b-lactamase positive but amoxicillin/clavulanate susceptible. Also, 97 SP strains were collected in Kuwait. The prevalence of PNSP was 60.8% (59/97) and erythromycin-nonsusceptible S. pneumoniae (ENSP) was 42.3% (41/97) in Kuwait. The level of susceptibility to XL, XM, and OF was 100% (97/97), 63.9% (62/97), and 96.9% (94/97), respectively.

Conclusion: XL and XM retained good in vitro activity against SP and HI strains. Among SP strains, the prevalence of quinolone non-susceptibility such as OF is increasing.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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