Antimicrobial effect of doxycycline on control of glycaemia in diabetic patients with moderate periodontitis after phase1 periodontal treatment

Abstract number: P1580

Zangeneh M., Zangeneh N., Naseh M., Poursamimi J., Golbon S.

Background: There are contradictory results of different studies about the effect of periodontal treatment on metabolic control of diabetes. Due to the importance of management of these patients, the purpose of this study was to examine the effect of periodontal treatment (scaling and root planning [SRP]) with doxycycline on glycemic control of type 2 diabetic patients.

Material and Methods: In this double blind randomized controlled clinical trial, 40 patients with type 2 diabetes mellitus who had moderate periodontitis were treated with SRP+ placebo (SRP; N = 20) or with SRP + doxycycline (SRP+Doxy; N = 20), 100 mg/day, for 21 days. Periodontal parameters including bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI), probing depth (PD) and also metabolic parameter (HbA1c) were recorded at baseline and 3 month after treatment.

Results: After 3 month, all periodontal parameters and HbA1c showed significant improvement in each group. (p < 0.001) The reduction of all periodontal parameters and HbA1c was not significant between two groups in this study (pBOP = 0.799), (pCAL=0.667), (pPI=0.253), (pPD=0.989), (pHbA1c = 0.301).

Conclusion: Periodontal treatment with the adjunctive systemic doxycycline therapy may influence the systemic conditions of patients with type 2 diabetes mellitus, but no statistical difference was observed between control and treatment groups. Therefore, confirmmatory studies with a larger sample and controlled diabetic patients is necessary.

Research supported by the Islamic Azad University, Tehran Medical Branch, Tehran, Iran.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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