Seasonality of Mycoplasma pneumoniae, Chlamydia pneumoniae, respiratory syncytial virus and adenovirus paediatric respiratory tract infections in northern Greece a2year study

Abstract number: P1492

Prodromidou S., Kanonidou C., Pape M., Anagnostou V., Mandraveli-Chatzikosta K., Dionysopoulou S., Diza E.

Objective:Mycoplasma pneumoniae (MP), Chlamydia pneumoniae (CP), Respiratory syncytial virus (RSV), and Adenovirus (AV) are among the pathogens of respiratory tract infections in childhood. The aim of this retrospective study was to investigate the seasonal distribution of these infections in a paediatric population in northern Greece and their association with local temperature conditions.

Methods: The study population consisted of 572 patients (2 months-6 year old) admitted to AHEPA University Hospital of Thessaloniki with symptoms of respiratory tract infection from 11/07 until 10/09. The presence of specific antibodies (IgG, IgM, IgA) was quantitatively determined by ELISA (RIDASCREEN, r-biofarm) in paired serum samples from each patient: for MP in 462, CP 356, RSV 72 and AV 409. x2 test and x2 goodness of fit test were performed.

Seasonality of M. pneumoniae, RSV, Adenovirus, and C. pneumoniae respiratory tract infections in children.

Results: 136 (30%) of 461 paired samples tested for the above pathogens in winter were positive. AV was the most common pathogen (44%). From 405 cases in spring, 94 (24%) were positive and MP infection was the most frequent (35%). 76 (27%) of 278 samples were positive in summer and the number of MP infections was the highest (54%). In autumn 55 (35%) of 158 samples were positive and AV infection was diagnosed in 50% of cases. MP exhibited a peak of activity in summer (38%), although no significant difference was found between the 2 years of study and different seasons as well. A spring peak of RSV positive cases (54%) was observed. The prevalence of RSV infections was lower in summer (41%) and autumn (41%). A significant reduction of positive cases occurred from autumn to winter (6%) (p < 0.05). AV infections reached a peak in autumn (50%). A significant raise was observed from summer to autumn (p < 0.01) and a significant reduction from winter to spring (p < 0.001). Statistical difference among the years of study was also observed (p < 0.01). CP was detected all year round. A significant increase of positive cases was found during the second year (p < 0.05). The mean monthly local temperature value did not vary significantly between the 2 years.

Conclusion: The occurrence of respiratory tract infections in children was almost the same all year round. Each pathogen demonstrated distinct seasonal patterns. The peak of MP infections was observed in summer, of RSV in spring and AV in autumn. Studies on seasonality are valuable for optimizing medical management.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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