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Carbapenem and multidrug-resistant Acinetobacter baumannii colonization/infection: epidemiology and factors associated to infection

Abstract number: P1308

Hernández-Torres A., García-Vázquez E., Yagüe G., Fernández-Rufete A., Moral-Escudero E., Gómez J., Canteras M., Albendín-Iglesias H., Herrero J.A., Ruiz J.

Objective: To study an outbreak of nosocomial colonisation/infection due to multidrug and carbapenem resistant A. baumannii (ABMDR-C).

Patients and Methods: Prospective study of patients with ABMDR-C colonisation/infection (January 2007-June 2008). Epidemiological and clinical variables and predictors of infection versus colonization were analysed.

Results: 24 out of 101 cases were considered colonisations and 77 infections (27 bacteraemia); global mortality (colonisations and infections) was 42% (4 colonisations and 38 infections – 18 bacteraemia). All together incidence was 3.2/1000 admissions/day; 29% had been previously admitted and 79% had received previous antibiotic treatment (29% carbapenem; 34% piperacillin–tazobactam; 12.5% boths); 78% had an underlying condition; 81% were UCI patients; 90% had gone through invasive procedures; 65% had another microorganism isolated. In multivariate analysis, infection predictor factors were isolation of ABMDR-C in respiratory samples (OR 5.406; 95% CI 1.419–20.599); male patients (OR 8.842; 95% CI 1.988–39.325); previous hospitalization (OR 9.720; 95% CI 1.383–68.291) and initial clinical severity (OR 30.897; 95% CI 5.533–172.543).

Conclusions: Our cohort of patients with ABMDR-C colonisation/infection is characterised by its underlying comorbidity, the high rate of previous invasive procedures, previous hospitalisation and previous broad-spectrum b-lactam treatments (especially carbapenem); initial severity and respiratory samples with ABMDR-C isolates were predictors of infection versus colonisation.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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