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Human immune deficiency virus infection in patients diagnosed at age 50 years or later

Abstract number: P1206

Almasi F.

Objectives: Age related immune deficiency is a well known entity. Having considered this fact, immune deficiency due to HIV infection may be more severe in older patients.

Methods: A retrospective observational study in registered HIV infected patients in order to review epidemiologic, clinical, laboratory data and response to treatment in patients diagnosed at age of 50 or older.

Results: Among 1680 registered HIV infected patient there are 91 HIV infected patients who found their HIV positive situation at age of 50–74, aged 50–84 years. There are 22 women (24%) and 69 men (76%). HIV transmission risk factor Is homosexual-bisexual contact in 44% of cases, heterosexual contact in 44%, blood and blood product transfusion in 2% and unknown risk factor in 10% respectively.

49 patients (54%) were asymptomatic (stage A of CDC), 16 patients (17.5%) symptomatic non-C(Stage B) and 26 patients (27.5%)present AIDS difining condition(stage C). CD4 count before treatment ranged between 4 and 754, as a mean 226 cells/ml. 35 patients (38.5%) present low CD4 count (less than 200) and 15 patients (16.5%) with CD4 less than 100 cells /ml.

79 patients (87%) are treated and 12 patients (13%) untreated including 1 patient with indication of treatment.

After treatment CD4 count ranged between 10 and 1511, as a mean 511. CD4 count before and after antiretroviral treatment was increased (285).

After treatment there were 14 patients with viral load more than 500 copies /ml including 8 untreated patients. It means 6 patients (7.6%) under treatment in virologic failure. There are 9 patients (11%) with detectable viral load but less than 500 copies/ml.

Conclusion: 76% of diagnosed patients at age of 50 or later are men. Male-female ratio is 3/1. Homosexual-bisexual contact is still an important risk factor in patients diagnosed at age 50 or more.

Age related immune deficiency in patients older than 50 is an important factor. Mean CD4 count was 226 in spite of 54% asymptomatic patients (stage A). It means that this group of patients is more immune deficient. After antiretroviral treatment there is pretty increase in CD4 count, it means a nice immunologic response.

Virologic response after treatment is as well as young even better may be because of better observance.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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