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Frequency of CCR5 delta 32 polymorphism and its relation to disease progression in Iranian HIV1 positive individuals

Abstract number: P1200

Moradmand Badie B., Najmabadi H., Esmaeeli Djavid G., Kheirandish P., Payvar F., Akhlaghkhah M., Jam S., Rasoolinejad M.

Objectives: The (CC) b-chemokine receptor 5(CCR5) is an important co-receptor for entry of human immunodeficiency virus type 1 (HIV-1) to CD4+ T cells. Homozygosity or heterozygosity for 32-nucleotide deletion (delta 32) within CCR5 gene may influence HIV acquisition and progression in HIV-1 exposed or positive individuals respectively. In this study, frequency of heterozygosity for CCR5 mutation in Iranian HIV positive population was determined and its relation with their disease progression was evaluated.

Methods: A total of 194 HIV positives patients from a referral health care center of HIV/AIDS in Tehran, were enrolled in this study in 2008. The CCR5 delta32 in peripheral blood mononuclear cells was detected by the polymerase chain reaction (PCR) and gel electrophoresis. The disease progression was determined based on changes in CD4 cell counts or clinical presentation of recruited patients.

Results: Eight (4.1%) of all 194 enrolled patients were heterozygous for (CCR5 delta 32) deletion 32 genotype (wt/del 32). We found no homozygosity for the mutated (del 32/del 32). One hundred three patients (42.9%) were in AIDS that through of them, 3 patients were heterozygote. Although frequency of rapid progression to AIDS was less in heterozygous individuals (37.5%) than in wild type patients (53.2%), this difference was not statistically significant (p = 0.4).

Conclusion: It seems that prevalence of CCR5 mutation in HIV-1 infected individuals is varying in Iranian normal population and it could be related to extensive ethnicity variation. Studies on larger population based on ethnicity may help to clarify the role of this mutation in progression pattern in Iran.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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