Aetiology of diarrhoea in patients at a university hospital in Sarajevo, Bosnia and Herzegovina

Abstract number: P1170

Dedeic-Ljubovic A., Hukic M., Salimovic-Besic I., Bekic D., Babic M., Arapcic S., Ramadani S.

Objectives: A prospective study was carried out to investigate the commonest etiologic agents of diarrhea for all ages from hospitalized patients.

Methods: Stool samples from 890 patients (adults and pediatric) with diarrhea admitted to the clinical center university of Sarajevo, Bosnia and Herzegovina from May 01 to October 31, 2009 were collected and processed for viral, bacteral, parasitic and yeast examination using standard methods.

Results: Overall, in 51% (458/890) of patients a potential pathogen is identified. A viral cause was found in 26% (233/890), bacterial in 17% (151/890), parasitic in 6.8% (24/890) and yeast in 5.6% (50/890) of cases. The occurrence of enteropathogens identified was as follows: rotavirus (151/458) 33%, Salmonella (122/458) 26.6%, with Salmonella enteritidis as the most common, astrovirus (54/458) 11.8%, diarrhoeagenic Escherichia coli (20/458) 4.3%, with enteropathogenic E. coli (EPEC) 044:K74, and enterohaemorrhagic E. coli (EHEC) O103:K- as the most common; Entamoeba histolytica (15/458) 3.2%, adenoviruses (9/458) 2%, Giardia lamblia (7/458) 1.5%, Campylobacter spp., Clostridium difficile toxin A+B and Shigella sonnei (3/458) 0.65%. No Yersinia enterocolitica was isolated. 9.4% of patients had mixed infection with two viral agent. Mixed viral and bacterial infection occured in 4% of patients. Most diarrheal episodes of viral and diarrhoeagenic E. coli etiology occured during the first three years of life. 10% (50/458) of patients with primarily non-gastrointestinal infection had elevated Candida counts in the stool. The majority of these patients were on antibiotic treatment. The most common species were Candida albicans and Candida glabrata. Salmonella and Shigella isolates were tested for their susceptibility to common antimicrobial agents and most of the isolates were sensitive to all tested antimicrobials.

Conclusion: This study demonstrated that rotavirus and Salmonella were significant enteropathogens. This study also, confirms that diarrhoeagenic E. coli is important causal agent of diarrheal diseases in pediatric patients in Bosnia and Herzegovina. Our results also suggest that antibiotics make an important contribution to the incidence of the elevated Candida counts in the stool from patients with diarrhea.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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